32results about How to "Preventive efficacy" patented technology

The present invention relates to methods for detecting polymorphisms in enzymes related to drug metabolizm (Drug Metabolizing Enzymes or DMEs) such as uridine diphosphate glucuronosyl transferase (UGT) gene promoter, cytochrome p450, with a non-amplified oligonucleotide detection assays. The present invention also relates to pharmacogenetic DME detection assay kits.

The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.

This invention relates to a culture medium used to efficiently propagate and acclimatize tissue cultured plantlets and thereafter obtain mature plantlets, a method to produce said medium, and a tissue culture method using said medium. The plant tissue culture medium is a novel plant tissue culture medium comprised in the main of vermiculite with an average particle diameter between 0.1-10 mm and cellulose fibers of an average fiber length between 0.01-5 mm. The culture method uses said culture medium in a light-transmissible container equipped at least in part with a porous gas permeable film, preferably having an air permeability between 1-50 sec / 100 ml as measured in accordance with JIS standard P8117. The solid culture medium formed from a specific type of vermiculite and cellulose fibers enables the culturing process as a whole to be performed easily and efficiently. Root development and plant growth are good, and healthy plants can be produced in a single culturing without the need for an acclimatization stage. Plantlets can also be transplanted directly without damaging the roots. Moreover, when this medium is used in combination with a light-transmissible container equipped with a gas permeable film, the aforementioned efficacy is noticeably improved.

This invention relates to a new composition containing the effective dosage of an aqueous extract of red vine leaves (1) and a diuretic (2) for preventing or alleviating the discomfort associated with mild-to-moderate chronic venous insufficiency of the legs. The compositions according to this invention may also contain pharmaceutically or dietetically acceptable additives.

The present invention relates to methods for detecting polymorphisms in enzymes related to drug metabolizm (Drug Metabolizing Enzymes or DMEs) such as uridine diphosphate glucuronosyl transferase (UGT) gene promoter, with nucleic acid detection assays. The present invention also relates to detection assay kits.

The invention discloses a numerical control acupuncture simulation manual therapeutical instrument which comprises a needle clamping mechanism, an insertion component, a rotating component and a control system for controlling the insertion component to complete insertion motions and controlling the rotating component to complete rotating motions. The numerical control acupuncture simulation manual therapeutical instrument further comprises an ejection mechanism for ejecting an acupuncture needle to penetrate in an acupuncture point. On the basis that a rotating and inserting mechanism is arranged, the ejection mechanism is additionally arranged, and the needle is aligned to the acupuncture point to be ejected during the acupuncture process, thus painless needle inserting is realized; and moreover, needle inserting and subsequent therapies are comprehensively simulated to realize conventional acupuncture manipulation, problems of poor curative effect and low efficiency which are caused by inexperienced operators can be avoided, and the stimulation amount of acupuncture manipulation can be unified and standardized, so that acupuncture gradually tends to accurate quantitative indexes, and the individual difference of manual operation is avoided, thus the personal error of an acupuncture clinical research treatment result is eliminated; and when being used, the acupuncture simulation manual therapeutical head stimulates the manipulation of known specialists, realizes intelligent simulation, is convenient and simple, and is high in therapeutical efficiency.

A broad spectrum disinfectant includes a quaternary ammonium halogen, an alkaline agent, a chelating agent, a nonionic surfactant coupler, at least one alkoxylated nonionic surfactant, and water or any aliphatic alcohol. The disinfectant composition is phenol-free, is effective in eradicating microorganisms such as various fungi, and is stable to gamma-irradiation.

The invention relates to a black fruit beer and a production process thereof, and provides a health care fruit beer containing black fruits. The black fruit beer is prepared by adding black fruits into a beer used as a base and fermenting. The black fruit beer comprises the following raw materials in parts by weight: 10-20 parts of triticale, 20-50 parts of wheat malt, 2-5 parts of black Chinese wolfberry, 2-5 parts of dark plum, 2-5 parts of black mulberry, 2-5 parts of hawthorn, 2-5 parts of black date, 2-5 parts of black grape and 2-5 parts of black currant. The production process comprises the following steps: screening the raw materials; pulverizing and juicing; gelatinizing; saccharifying; filtering; boiling; fermenting; filtering; and canning. The beer disclosed by the invention has aromatic fruit flavor, is full-bodied, smooth, tasty and refreshing in mouthfeel, has the effects of clearing away heat and toxic materials, promoting salivation, quenching thirst, improving digestion and resisting aging, and can obviously improve the immunity of a human body.

Provided herein are compositions and methods for inhibiting cancer cell motility and / or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies (e.g., cancer therapies (e.g., hormone therapies and chemotherapies) are provided to inhibit cancer cell motility, inhibit metastasis, and / or treat cancer (e.g., prostate cancer, lung cancer, breast cancer, colon cancer, etc.).

The present disclosure relates to a novel crystalline form of lenvatinib mesylate and the preparation method thereof. The novel crystalline form of mesylate of the present disclosure can be used for treating invasive and differentiated thyroid cancer. The novel crystalline form of mesylate of the present disclosure has good solubility, stability, and remarkable purification effect in process. The preparation method of this novel crystalline form is simple, low cost, and has an important value for future optimization and development of the drug.

A light emitting diode includes a light emitting structure including first and second conductive type semiconductor layers and an active layer disposed therebetween, a second hole formed through the active layer and the second conductive type semiconductor layer, and exposing the first conductive type semiconductor layer, a reflective metal layer contacting a portion of the light emitting structure, a cover metal layer contacting at least a portion of the reflective metal layer, a first insulation layer covering the reflective metal layer and the cover metal layer, an electrode layer disposed on the first insulation layer, the electrode layer covering the first insulation layer and filling the second hole, an electrode pad disposed on the light emitting structure, and a first hole formed through the first conductive type semiconductor layer and corresponding to the cover metal layer, in which the electrode pad overlaps the cover metal layer.

The invention discloses a composite probiotic spray for preventing and treating newborn livestock diarrhea, and discloses a preparation method of the spray. The composite probiotic spray for preventing and treating newborn livestock diarrhea is prepared from the following raw materials in parts by weight: 200-1,000 parts of adsorptive support, 400-2,000 parts of coated support and 100-200 parts of probiotic composition. The preparation has the effects of regulating intestinal micro-ecological balance of newborn young livestock, keeping normal physiological functions of intestines, enhancing immunity of organisms, improving the disease resistance of organisms, and in particular effectively preventing physiological and pathological diarrhea of young livestock. The composite probiotic spray is unique in dosage form, convenient and efficient to apply, more suitable for newborn young livestock, and is suitably popularized and applied in animal husbandry production.

The invention discloses an HPLC (high performance liquid chromatography) method for detecting concentration of voriconazole in human plasma and relates to the technical field of medical treatment. TheHPLC method is established for detecting the concentration of voriconazole in the human plasma, which aims to provide reference for clinical rational drug use. The method comprises steps as follows:determination of chromatographic conditions, preparation of solutions, treatment of plasma samples, retention of voriconazole and internal standard chlorzoxazone, taking of an appropriate quantity ofa voriconazole stock solution, preparation of voriconazole, preparation of voriconazole, and taking of quality control plasma samples with low, medium and high mass concentrations. The method is simple to operate, has an accurate result, is suitable for detecting voriconazole in human plasma, and can assist in avoiding poor curative effect or increased adverse reactions caused by too low or too high plasma concentration. An experimental result of the HPLC method for detecting the concentration of voriconazole in the human plasma meets the measuring requirement of biological samples and is suitable for concentration monitoring of clinical treatment and pharmacokinetic study.

The invention discloses an acupuncture simulation manual therapeutical head which comprises a needle clamping mechanism, an inserting component and a rotating component. The acupuncture simulation manual therapeutical head further comprises an ejection mechanism for ejecting an acupuncture needle to penetrate in an acupuncture point. On the basis that a rotating and inserting mechanism is arranged, the ejection mechanism is additionally arranged, and the needle is aligned to the acupuncture point to be ejected during the acupuncture process, thus painless needle inserting is realized; moreover, needle inserting and subsequent therapies are comprehensively simulated to realize conventional acupuncture manipulation, problems of poor curative effect and low efficiency which are caused by inexperienced operators can be avoided, the stimulation amount of acupuncture manipulation can be unified and standardized, so that acupuncture gradually tends to accurate quantitative indexes, and the individual difference of manual operation is avoided, thus the personal error of an acupuncture clinical research treatment result is eliminated; and when being used, the acupuncture simulation manual therapeutical head stimulates the manipulation of known specialists, is convenient and simple, and is high in therapeutical efficiency.

The invention discloses a traditional Chinese medicine composition for preventing and treating liver and gastrointestinal cancer. The traditional Chinese medicine composition comprises the following components: 30-60g of barbated skullcup herb, 30-60g of spreading hedyotis herb, 30-60g of kiwi stems, 30-50g of common selfheal fruit-spike, 50-150g of wild vegetable seeds and 100-200g of pig liver.The traditional Chinese medicine composition takes the wild vegetable seeds and the pig liver as base materials, the barbated skullcup herb, the spreading hedyotis herb and the common selfheal fruit-spike are added, so that the composition has a good curative effect of treating and preventing liver cancer. The kiwi stems are further added, so that the curative effect of treating and preventing liver cancer is improved, and the curative effect of treating and preventing gastrointestinal cancer is remarkable. The wild vegetable seeds of the invention are wild papaya seeds which are bitter and cold in nature and taste, and contain some natural charantin. The charantin can effectively balance blood glucose, improve the pancreas islet function and repair damaged tissue cells, and is beneficialto improving the curative effect of treating and preventing liver and gastrointestinal cancer. The traditional Chinese medicine composition also comprises adjuvant components, so that the curative effect of a medicine for treating and preventing liver cancer is further improved, and meanwhile, the taste of the medicine is improved.

The present disclosure relates to a novel crystalline form of lenvatinib mesylate and the preparation method thereof. The novel crystalline form of mesylate of the present disclosure can be used for treating invasive and differentiated thyroid cancer. The novel crystalline form of mesylate of the present disclosure has good solubility, stability, and remarkable purification effect in process. The preparation method of this novel crystalline form is simple, low cost, and has an important value for future optimization and development of the drug.

Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and / or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.

The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin αvβ3 (also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, reflects a high tumor image of the tricatvonyl technetium-99m labeled cyclic RGD derivative after initial intake in an animal in which cancer cells are transplanted, and acts exclusively upon cancer cells having selectively activated integrin αvβ3 because of a substantially low intake into the liver and intestines, compared to existing known radioactive isotope labeled cyclic RGD derivatives. These results show that the rhenium-188 labeled derivative, a therapeutic nuclide using the same precursor as used in the technetium-99m labeling, effectively inhibits the growth of a tumor and demonstrates therapeutic efficacy when administered via tail vein injection to an animal model bearing tumor, compared to a case where only saline has been injected, thereby making it useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.

The invention discloses a traditional Chinese medicine composition for treating breast diseases. The composition includes 15-30 g of motherwort herb, 5-15 g of rose, 30-60 g of barbed skullcap, 10-30g of pine pollen, 10-30 g of kelp, 5-10 g of edible mirabilite, and 10-30 g of radix notoginseng. The motherwort herb, the barbed skullcap and the kelp are taken as main materials to condition mammarygland; the rose and the radix notoginseng are added to rectify qi, invigorate blood circulation and eliminate pain and swollen breasts; and the edible mirabilite and the traditionally external pine pollen can be further added, the mirabilite can moisturize dryness and soften hardness and relieve inflammation and detumescence so that mammary gland conditioning effects can be enhanced, and the pinepollen can tonify qi and eliminate wind-damp through oral administration so that inflammation and detumescence can be further relieved to condition the mammary gland, and therefore, the composition has significant curative effects on treating and preventing breast diseases; the edible mirabilite is prepared from impure mirabilite naturally generated, so that the edible mirabilite does not containadditives and is good in curative effect; and in addition, the pine pollen is the Chinese pine pollen and collected from Chinese pines, is sweet in taste and warm in nature, has astringency and hemostasis, and can dry dampness and effectively condition the mammary gland.

The invention discloses an HPLC-UV method for detecting the concentration of levetiracetam in human plasma. The method is characterized in that the concentration of levetiracetam in human plasma is detected by combining a methanol direct protein precipitation method with HPLC-UV, the concentration of levetiracetam can be detected only by using a very small amount of plasma, the linear range is 2-100 [mu]g / mL (R2 is more than 0.99), the intra-batch precision and the inter-batch precision are both smaller than or equal to 3.58%, and the accuracy range is 96.09-97.86%. According to the present invention, the detection limit is low, the selectivity is good, the specificity and the sensitivity are extremely good, the whole detection time is short, the residue, the interference and the extraction recovery rate meet the requirements, and the detection result is stable.

The invention discloses an external preparation for skin eczema. The external preparation is prepared from 0.1%-0.5% of menthyl p-methoxy cinnamic acid, 0.5%-5% of carboxyamino chitosan, 50%-80% of traditional Chinese medicine extract and the balance purified water. The preparation method of the preparation comprises the following steps that 1, the traditional Chinese medicine extract is prepared;2, a carboxyamino chitosan solution is prepared; 3, the menthyl p-methoxy cinnamic acid is prepared; 4, a finished product is obtained. The external preparation prepared through the method for the skin eczema has the good percutaneous absorption effect, the traditional Chinese medicine ingredients and the menthyl p-methoxy cinnamic acid and the carboxyamino chitosan have the good synergy effect,the traditional Chinese medicine active ingredients have the good percutaneous absorption effect, various pruritus and infections caused by the skin eczema can be rapidly relieved, and meanwhile the defects that traditional Chinese medicine water extract contaminates clothes, the curative effect is poor, and precipitation is separated out are avoided, preservative does not need to be added for thepreparation, it is guaranteed that liquid medicine containing the traditional Chinese medicine ingredients does not mildew, and the phenomena that due to a commercial aseptic operation, the characteristic curative effect changes, and the cost is lower are avoided.

The invention belongs to the technical field of rat models, and discloses a deep hypothermic circulatory rat animal model. According to the model, 60 healthy male rats with the weight of 350-450 g areprepared, the respiratory frequency, airway pressure, arterial pressure and heart rate change of the rats are measured, blood enters a venous kettle through a venous drainage pipe, and the blood is pumped into a micro oxygenator through a digital flow-controllable transfer pump; after a priming solution and a brain protection solution are prepared, circulation is stopped for 60 minutes in a precise constant-temperature bath tank and in an in-vitro ice crumble environment, brain protection tissue is discontinuously subjected to antegrade cerebral perfusion protection, then circulation is restored, the body surface and the blood are subjected to rewarming at the same time, and finally a measurement result is obtained. The model is easy to operate, consumes less manpower and material resources, is short in period, simple, reliable, economical and practical, and has great research significance.

The invention provides a seedless kiwi fruit and bitter gourd jam processing method. The processing method comprises the following steps: raw material selecting, cleaning, shelling, vacuum cooking, jamming, seed removing, weighing, condensing, bottling and sealing when the jam is hot, sterilizing and finished-product packaging. According to the seedless kiwi fruit and bitter gourd jam processing method, fresh kiwi fruit and fresh bitter gourd are subjected to vacuum cooking, jamming, seed removing and condensing, so that the tastes of the fresh kiwi fruit and the fresh bitter gourd are kept, the sugar content of jam is largely reduced, the processed jam can be taken as leisure food and also has healthcare, beautifying and disease-preventing effects.