3results about How to "Preventive efficacy" patented technology

The utility model discloses a kind of flower leaf type traditional chinese medicine spray drying device, including support frame and drying cabinet, placing mechanism is equipped in drying cabinet, and driving mechanism for driving the rotation of placing mechanism is equipped in support frame, drying mechanism is equipped in the bottom of drying cabinet with the communication of drying cabinet interior, and exhaust mechanism is equipped in the top of drying cabinet with the communication of drying cabinet interior.Using the spray drying device of the utility model, by timely drying treatment to the flower leaf type traditional chinese medicinal materials after harvesting, not only can avoid the problem of mildewing and metamorphic, but also can effectively avoid the effective component in flower leaf type traditional chinese medicinal materials, due to the problem of enzymatic hydrolysis and hydrolysis, thereby leading to the problem of the decline of medicinal material quality and clinical efficacy reduction, it is conducive to improving traditional chinese medicinal material quality, to satisfy the use requirement of flower leaf type traditional chinese medicinal materials, its overall structure is simple, convenient operation and use, especially for flower leaf type traditional chinese medicinal materials, it is conducive to greatly improving its drying efficiency, suitable for use.

The invention discloses a crisaborole ointment and a production process thereof. The crisaborole ointment is prepared from crisaborole, white vaseline, liquid paraffin, glyceryl monostearate and glyceryl distearate, glycerol, propylene glycol, butylated hydroxytoluene, ethylenediamine tetraacetic acid disodium salt, dimethyl sulfoxide and benzalkonium chloride. The preparation method comprises the following steps: 1, synthesizing crisaborole; step 2, preparing an ointment matrix; step 3, preparing and mixing a solution; step 4, emulsifying and homogenizing; and step 5, filling and packaging. Step 6, quality control; the butylated hydroxytoluene is added as an antioxidant to effectively prevent the effective components in the ointment from being oxidized in the preparation and storage processes, and the ethylene diamine tetraacetic acid is added as a metal chelating agent to chelate metal ions, so that the potential adverse effects of the metal ions on the stability and curative effect of the ointment are effectively prevented, and the ointment is safe and reliable. The purity and the safety of the ointment are ensured, and the oxidation resistance and the metal ion interference resistance of the ointment are enhanced.

This application relates to the field of biomedicine, specifically to the use of small molecule compounds in the preparation of drugs for the treatment and / or prevention of α-synuclein diseases, wherein the small molecule compounds are selected from at least one of AO-365 / 43264238 and AG-670 / 40728295. The small molecule compounds provided in this invention can precisely target and interfere with α-syn-VAPB interactions, improving neuronal damage caused by abnormal aggregation of α-synuclein, thereby safely and effectively treating and / or preventing α-synuclein diseases, particularly Parkinson's disease.