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Forsythia seed extract and its prepn process

A technology of forsythia and forsythol, applied in the field of traditional Chinese medicine, can solve the problems of few forsythia and no description, etc., and achieve the effect of high product yield

Active Publication Date: 2007-10-17
山西振东五和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on forsythia
After a preliminary search, it was found that the patent titled "Use of Forsythia or its extracts in the preparation of antibacterial and antiviral drugs or health products" published in 2004 involves the antibacterial and antiviral use of Forsythia. However, how to obtain High content of forsythol, not described

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 500 grams of Fructus Forsythiae, distill and extract Fructus Forsythiae 3 times with 3000ml of water, each time for 1.5-2.5 hours, combine the extracts, filter, and concentrate under reduced pressure to a water extract with a relative density of 1.1 (50°C); Add 100 grams of diatomaceous earth to the water extract, mix the two well, and dry in the air; add 1500 ml of 70% ethanol to the dried mixture, stir and elute 3 times, filter after stirring for 30 minutes each time, and combine For the filtrate, recover the solvent under reduced pressure until the relative density is 1.25-1.3, add 1000-1500ml of water, and filter; the filtrate slowly passes through the macroporous resin, the resin weight is 1500 grams, and the flow rate is 1000L / m2·h. After passing through, the residual impurities in the resin column were washed away with 7500ml of water, then desorbed with 3750ml of 80% ethanol, and the ethanol solution was concentrated to dryness under reduced pressure to obta...

Embodiment 2

[0021] Celite adsorption, 70% ethanol desorption

[0022] Effective part yield: 36.80 / 500=7.36%

Embodiment 3

[0024] Take 500 grams of Fructus Forsythiae, distill and extract Fructus Forsythiae 3 times with 3500ml of water, each time for 1.5-2.5 hours, combine the extracts, filter, and concentrate under reduced pressure to a water extract with a relative density of 1.20 (50°C); Add 150 grams of diatomaceous earth to the water extract, mix the two thoroughly, and dry; add 80% ethanol 1800ml to the dried mixture, stir and elute 3 times, and filter after stirring and eluting for 30 minutes each time. Combine the filtrates, recover the solvent under reduced pressure until the relative density is 1.25-1.3, add 1000-1500ml of water, and filter; the filtrate slowly passes through the macroporous resin with a flow rate of 2000L / m2·h. After passing through, the residual impurities in the resin column were washed away with 7500ml of water, then desorbed with 4250ml of 85% ethanol, and the ethanol solution was concentrated to dryness under reduced pressure to obtain 34.9 grams of yellow forsythol...

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PUM

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Abstract

The forsythia seed extract is prepared through the main steps of: water extraction, adsorbing with diatomite via stirring, alcohol aqua eluting and filtering, macroporous resin adsorption, etc. The adsorbent is purified first with diatomite and then with macroporous resin and elutent is water solution of alcohol in different concentrations. The extract has high effective component content and forsythol content over 60 wt%. The preparation process uses non-toxic cheap adsorbent and elutent and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting and separating effective parts of forsythia, in particular to a method for extracting and separating forsythiaol, and belongs to the field of traditional Chinese medicines. technical background [0002] Forsythia suspensa (Forsythia suspensa) is a perennial deciduous shrub of Oleaceae family, slightly cold in nature and bitter in taste. It has the functions of clearing away heat and detoxification, reducing swelling and dissipating stagnation. At present, most of the research on the extract of Forsythia is on the leaves and flowers of Forsythia. However, there are relatively few studies on forsythia. After a preliminary search, it was found that the patent titled "Use of Forsythia or its extracts in the preparation of antibacterial and antiviral drugs or health products" published in 2004 involves the antibacterial and antiviral use of Forsythia. However, how to obtain The high content of forsythol wa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B63/00A61K36/634A61K9/14A61P31/04A61P31/12
Inventor 玄振玉
Owner 山西振东五和堂制药有限公司
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