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Pain-relieving

A technology of babu ointment and realgar, applied in the direction of non-central analgesics, medical preparations containing active ingredients, medical formulas, etc., can solve the problems of increased blood lead and urine lead content, inconvenient use and storage, and effective Chinese herbal medicine. Low ingredients and other issues, to achieve high drug loading, non-allergic transdermal absorption, and facilitate transdermal absorption

Inactive Publication Date: 2007-10-31
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the current clinical pain relief for various diseases, western medicine generally uses poisonous anesthetic preparations, which are prone to drug resistance and addiction, and oral administration of drugs has relatively large side effects on the body; in external plasters, the commonly used traditional Chinese medicine preparation black plaster contains Lead, long-term use can significantly increase the content of lead in human blood and urine, which is difficult for patients to accept, and also causes pollution to the environment
Pain-relieving babu ointment has a rich clinical application basis. The prescription contains famous and precious traditional Chinese medicines such as realgar, notoginseng, frankincense, and myrrh, which have the effects of analgesia, anti-cancer, and detumescence, and the clinical effect is remarkable and definite. , but most of them are pastes at present, which must be temporarily prepared, and the volume is large, which is inconvenient to use and store
Chinese patent CN1290530A discloses a kind of Aitongning babu ointment and its preparation method. The active ingredients of the Chinese herbal medicines that can be extracted are relatively low, and the prepared Atong Ningbabu ointment has a certain analgesic effect on various cancer pains, but the curative effect is still unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A) Take 100g of realgar, pick up impurities, coarsely pulverize, dry under the temperature condition of 60°C after preliminary water flying, and ultrafinely pulverize with jet mill for half an hour to obtain 85g of realgar superfine powder, set aside, the obtained particles are 50% of the particles The particle size is less than 4.18μm, the distribution is relatively concentrated, and the processing process can effectively avoid the generation of a large amount of heat to oxidize the realgar;

[0032] B) Take 200g of Panax notoginseng, crush it into a coarse powder, and extract twice with 70% ethanol under reflux, adding alcohol 8 times the weight of the medicinal material each time, extracting for 1.5 hours each time, combining the reflux liquid, and recovering the ethanol under reduced pressure until the drug content is 0.3 g·ml -1 , the extract was passed through the AB-8 macroporous adsorption resin column, washed with distilled water until the Molish reaction of th...

Embodiment 2

[0037] A) Take 50g of realgar, pick up impurities, coarsely pulverize, dry under the temperature condition of 40°C after preliminary water flying, and ultrafinely pulverize with a jet mill for half an hour to obtain 36g of realgar superfine powder, set aside, the obtained particles are 50% of the particles The particle size is less than 4.60μm, the distribution is relatively concentrated, and the processing process can effectively avoid the generation of a large amount of heat to oxidize the realgar;

[0038] B) Take 100g of Panax notoginseng, crush it into a coarse powder, and extract twice with 65% ethanol under reflux, each time adding alcohol to 7 times the weight of the medicinal material, extracting for 1.0 hour each time, combining the reflux liquid, and recovering the ethanol under reduced pressure until the drug content is 0.5 g·ml -1, the extract was passed through the AB-8 macroporous adsorption resin column, washed with distilled water until the Molish reaction of ...

Embodiment 3

[0043] A) Take 70g of realgar, pick up impurities, coarsely pulverize, dry under the temperature condition of 60°C after preliminary water flying, and ultrafinely pulverize with a jet mill for half an hour to obtain 45g of realgar superfine powder, set aside, the obtained particles are 50% of the particles The particle size is less than 4.42μm, the distribution is relatively concentrated, and the processing process can effectively avoid the generation of a large amount of heat to oxidize the realgar;

[0044] B) Take 120g of Panax notoginseng, crush it into a coarse powder, and extract twice with 75% ethanol under reflux, add 9 times of alcohol each time, extract for 2 hours each time, combine the reflux liquid, and recover the ethanol under reduced pressure until the drug content is 0.4g ·ml -1 , the extract was passed through the AB-8 macroporous adsorption resin column, washed with distilled water until the Molish reaction of the effluent was negative, then eluted with 55% ...

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Abstract

An analgesic Chinese medicine in the form of plaster is prepared from realgar, motoginseng, frankincense, myrrh and borneol through pre-treating, mixing with percutaneous absorption promoter and matrix, stirring, coating it on substrate, adding protecting film, cutting by needed sizes and packing. It features high curative effect, biocompatibility, air permeability and moisture preserving nature and no anaphylaxis.

Description

technical field [0001] The invention relates to a preparation method of analgesic medicine, more specifically relates to a preparation method of analgesic babu ointment using Chinese herbal medicine as a raw material, and belongs to the field of traditional Chinese medicine. Background technique [0002] In the current clinical pain relief of various diseases, western medicine generally uses poisonous anesthetic preparations, which are prone to drug resistance and addiction, and oral administration of drugs has relatively large side effects on the body; in external plasters, the commonly used traditional Chinese medicine preparation black plaster contains Lead, long-term use can significantly increase the content of lead in human blood and urine, which is difficult for patients to accept, and also causes pollution to the environment. Pain-relieving babu ointment has a rich clinical application basis. The prescription contains the famous and precious traditional Chinese medic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/328A61K36/25A61K36/324A61K9/70A61P29/02
Inventor 贾晓斌朱启勇陈彦王勇
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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