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Nimesulide sustained release medicinal composition

A slow-release composition and weight ratio technology, which is applied in the direction of drug combination, drug delivery, amide active ingredients, etc., can solve the problems of complex processing and high cost, and achieve obvious slow-release effect, low cost and good slow-release performance Effect

Active Publication Date: 2007-11-07
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The controlled-release composition can control the active ingredients of the drug to release the drug at a fixed time and quantity at a zero-order rate, and the processing is complicated and the cost is high.

Method used

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  • Nimesulide sustained release medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] 1. According to 200g of nimesulide, hydroxypropyl methylcellulose with brand name K4M (its methoxyl content is 19.0%-24.0%), brand name is E 50 Hydroxypropylmethylcellulose (methoxyl content is 28.0%-30.0%), three kinds of sustained-release matrix materials of ethylcellulose, the test amount shown in the table below, lactose 2.5g, magnesium stearate 1.5g weighed Get the raw and auxiliary materials through an 80-mesh sieve and mix them evenly.

[0029] 2. Weigh an appropriate amount of ethyl cellulose, add ethanol to dissolve, and make 2% ethyl cellulose ethanol solution.

[0030] 3. Add an appropriate amount of 2% ethyl cellulose ethanol solution dropwise to the mixed raw and auxiliary materials to make soft materials, and pass through a 20-mesh sieve to make granules.

[0031] 4. Dry the granules at 60°C for 4 hours, take out the whole granules, measure the content, and fill with No. 0 capsules.

[0032] The sustained-release matrix material of the nimesulide sustain...

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PUM

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Abstract

A slow-release composition of nimesulide is proportionally prepared from nimesulide, hydro-xyproply methylcellulose containing methoxy (19-24), hydro-xyproply methylcellulose containing methoxy (28-30), ethylcellose, lactose, magnesium stearate, and alcohol solution of ethyecellulose.

Description

technical field [0001] The invention relates to a nimesulide sustained-release composition, which involves combining appropriate auxiliary materials with nimesulide to delay the release of nimesulide, and can be made into a once-a-day dosage form. Background technique [0002] Nimesulide is a non-steroidal anti-inflammatory drug with antipyretic and analgesic activity. The therapeutic effect is mainly due to its ability to inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase. But this action also inhibits gastroprotective prostaglandins, leading to gastrointestinal intolerance. The current clinical specification of nimesulide tablets is 100mg / tablet, taken twice a day, 100mg each time. For poorly soluble drugs such as nimesulide, the release of such tablets is prone to instability and variability under in vivo conditions. [0003] The invention patent application with publication number CN1399543A discloses a controlled-release composition containing nimes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/18A61K9/52A61P29/00
Inventor 汤小东汤旭东
Owner HAINAN HULUWA PHARMA GRP CO LTD
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