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Pressure lowering maijunan capsule and its preparation method

The technology of Maijunan and capsules is applied in the field of traditional Chinese medicine and its preparation, which can solve the problems of many toxic and side effects of chemical drugs, unfavorable health, easy to produce drug resistance, etc., and achieves a remarkable total effective rate of treatment and an increase in the total effective rate of treatment. , improve the effect of drug efficacy

Inactive Publication Date: 2008-04-23
SINOPHARM ZHONGLIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the antihypertensive drugs commonly used by hypertensive patients are chemical drugs, but the toxic and side effects of chemical drugs are more, and hypertension is a disease of long-term medication, long-term use of chemical drugs will not be conducive to the health of the body, and drug resistance is easy to develop , and as a pure Chinese medicine, antihypertensive drugs have the disadvantages of large doses and slow onset of action

Method used

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  • Pressure lowering maijunan capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Get Uncaria 14.70kg, Puerariae 5.49kg, Hydrochlorothiazide 0.015kg, and auxiliary materials 0.7kg. Break Uncaria and Pueraria lobata into a coarse powder of 0-20 mesh, add 85% ethanol to impregnate the coarse powder, make the coarse powder fully swell, leave it for 1 hour, and use 85% ethanol as a solvent to carry out reflux extraction twice, the first time Adding 85% ethanol at a concentration of 10 times the weight of the raw material, and adding 85% ethanol at a concentration of 8 times the weight of the raw material for the second time, every 2 hours, collecting the extract, reclaiming the ethanol, concentrating into an extract, spraying and drying with Mix hydrochlorothiazide and auxiliary material fine powder evenly, pack into capsules, make 10,000 capsules of 0.3g. The auxiliary materials are sucrose, dextrin, starch or lactose.

example 2

[0018] Get Uncaria 14.70kg, Puerariae 5.49kg, Hydrochlorothiazide 0.015kg, and auxiliary materials 0.7kg. Break Uncaria and Pueraria 2kg into coarse powder of 0-20 mesh, add 85% ethanol to impregnate the coarse powder, make the coarse powder fully expand, let stand for 24 hours, and use 85% ethanol as solvent for percolation extraction, the concentration is 60-90 The addition of % ethanol is 8 times of raw material weight, collect percolation liquid with percolation speed (10-50ml / 50kg), after reclaiming ethanol to percolation liquid, concentrate into extractum; powder, mixed evenly with the extract, made into granules, packed into capsules, and made into 10,000 capsules of 0.3g. The auxiliary materials are sucrose, dextrin, starch or lactose.

[0019] Quality inspection: loading difference: 0.3g±7.5%, disintegration time: less than 30 minutes.

example 3

[0021] Such as figure 1 Shown, a kind of Jiangya Maijunan capsule and preparation method thereof, comprises the steps:

[0022] 1). The selection of raw materials, by weight percentage: Uncaria 59.8%, Pueraria 40%, Hydrochlorothiazide 0.2%, choose Uncaria, Pueraria, and Hydrochlorothiazide;

[0023] 2). Extraction: crush the uncaria and 30% kudzu root in the raw material into a coarse powder of 0-20 mesh, add 60% ethanol to impregnate the coarse powder with a concentration of 1 times the weight of the raw material, so that the coarse powder is fully expanded, and stand for 48 hours , and with the concentration of 60% ethanol as the solvent to extract the active ingredient, the concentration of 60% ethanol is 4 times the weight of the raw material, and the percolation speed is 10-50ml / 50kg to collect the percolation liquid, and the percolation liquid is carried out After recovering ethanol, it is concentrated into extract;

[0024] 3). Hydrochlorothiazide and the remaining 70...

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Abstract

A Chinese medicine in the form of capsule for treating hypertension is prepared from uncaria stem with hooks, pueraria root and hydrochlorothiazole. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a preparation method of Maijunan Capsules for treating hypertension. Background technique [0002] Hypertension is a disease with the highest incidence among middle-aged and elderly people. With the rapid development of modern science, the improvement of people's living standards in our country, the change of dietary structure, and the acceleration of work rhythm, the incidence of hypertension is gradually increasing. Develop at a rate of 3 million new people every year. At present, most of the antihypertensive drugs commonly used by hypertensive patients are chemical drugs, but the toxic and side effects of chemical drugs are more, and hypertension is a disease of long-term medication, long-term use of chemical drugs will not be conducive to the health of the body, and it is easy to produce drug resistance , and as the antihypertensive drug of p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K36/48A61K9/48A61P9/12
Inventor 孙月英陈俊刘孔明李小莉
Owner SINOPHARM ZHONGLIAN PHARMA CO LTD
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