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Production process of N-acetylamino gluceo metho aldehyde acetal

A technology of glucosamine and glucosamine hydrochloride, which is applied in the direction of acyclic sugar and can solve the problems of complex process and low yield

Inactive Publication Date: 2008-06-25
JIANGSU SHUANGLIN MARINE BIOLOGICAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing production method of N-acetylglucosamine methylal has complicated process and low yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0014] A production method of N-acetylglucosamine methylal, comprising the following steps in turn:

[0015] ① Neutralize glucosamine hydrochloride with an acid-binding agent composed of methanol and sodium methoxide for 15 to 30 minutes (example 15, 20, 25, and 30 minutes), and desalt to obtain glucosamine. The weight ratio of methanol to sodium methoxide in the acid-binding agent is 1:2-4 (eg 1:2, 1:3, 1:4). The consumption of acid binding agent is 20~40% (for example 20%, 30%, 40%) of glucosamine hydrochloride by weight.

[0016] ② Carry out acetylation reaction of glucosamine and acetic anhydride to obtain N-acetylglucosamine; the temperature of acetylation reaction is 0°C±5°C, and the time is 50-70 minutes (Example 50, 60, 70 minutes).

[0017] ③Refluxing N-acetylglucosamine in the presence of sulfuric acid and methanol at 70-80°C (Example 70, 75, 80°C) for 20-30 minutes (Example 20, 25, 30 minutes) for acetalization reaction , in N-acetylglucosamine formal. During the...

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Abstract

The invention discloses a producing method of N-acetamino glucose methylal, including: neutralizing amino glucose hydrochloride and agent, obtaining amino glucose, acetylating the amino glucose by acetic anhydride to obtain N-acetamino glucose, making acetalation reaction on the N-acetamino glucose on condition of sulphuric acid and methanol existing, obtaining N-acetamino glucose methylal. It has simple producing method and high purity of product; high yield of product, up to 80% above.

Description

Technical field: [0001] The invention relates to a production method of N-acetylglucosamine methylal. Background technique: [0002] With the development of immunochemistry, scientific research shows that oral administration of N-acetylglucosamine formal can timely regulate the content of N-acetylglucosamine formal in the blood, and transfer it into human cells in time to improve the function of joint tissues. Due to the fast absorption and transformation speed and good taste, it can be fed directly in the microbial fermentation process, which is conducive to increasing the active ingredient content of functional drinks and increasing the curative effect. Therefore, most of the active ingredients of functional drinks developed in domestic and foreign markets, such as immune drinks and in vivo microbial population adjustment drinks, are substitutes for N-acetylglucosamine methylal. [0003] The existing production method of N-acetylglucosamine methylal has complicated proces...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H7/02
Inventor 彭秀兰梁双林
Owner JIANGSU SHUANGLIN MARINE BIOLOGICAL PHARM CO LTD