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Elemene soft capsule and its preparation process

A soft capsule preparation and technology of elemene are applied in the field of soft capsule preparation of antitumor drug elemene and its preparation, which can solve the problems of unsuitable taste and the like, and achieve convenient clinical medication, high bioavailability in human body, and high bioavailability. fast effect

Inactive Publication Date: 2008-07-23
刘玉辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to overcome the disadvantage of unsuitable taste in the existing elemene pharmaceutical preparations, adopt specific auxiliary materials and capsule materials, and control the process conditions to make elemene into soft capsule preparations, thereby solving the problem of elemene odor. problem, and its good stability makes it suitable for clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Elemene Soft Capsule Contents: Elemene 200g

[0035] The above formula is made into 1000 capsules of elemene soft capsule preparation.

[0036] Its preparation method is as follows:

[0037] (1) Preparation of capsule material:

[0038] Using gelatin, glycerin and water as raw materials, according to the weight ratio, gelatin: glycerin: water is 1: 0.4: 1, put the above materials into the interlayer tank and stir, steam heat the interlayer, make the materials fully melt and keep warm for 1-2 hours, After standing still until the foam floats up, adjust the pH value of the solution to 6.0 with hydrochloric acid, keep warm at 60°C and filter, and the glue is ready for use;

[0039] (2) Preparation of soft capsules:

[0040] a). The elemene of prescription quantity is placed in suitable container, adds in the hopper for subsequent use;

[0041]b). Put the glue prepared in step (1) into the rubber hopper, and keep it at 60°C-70°C; make the elemene and the glue drip out f...

Embodiment 2

[0043] Contents of Elemene Soft Capsules:

[0044] Elemene 200g

[0045] Edible soybean oil 85g

[0046] Tween-80 15g

[0047] The above formula is made into 1000 capsules of elemene soft capsule preparation.

[0048] Its preparation method is as follows:

[0049] (1) Preparation of capsule material:

[0050] Using gelatin, glycerin, titanium dioxide, bright black and water as raw materials, the ratio by weight, gelatin: glycerin: titanium dioxide: bright black: water is 1: 0.3: 0.05: 0.5: 0.7, put the above materials into the interlayer tank and stir, steam heating Interlayer, after fully melting the material and keeping it warm for 1-2 hours, let it stand until the foam floats up, adjust the pH value of the solution to 6.5 with hydrochloric acid, keep warm at 60°C and filter, and prepare the glue for later use;

[0051] (2) Preparation of soft capsules:

[0052] a). Place the elemene, edible soybean oil, and Tween-80 of the prescribed amount in a suitable container, st...

Embodiment 3

[0055] Contents of Elemene Soft Capsules:

[0056] Elemene 150g

[0057] Edible soybean oil 140g

[0058] Tween-80 10g

[0059] The above formula is made into 1000 capsules of elemene soft capsule preparation.

[0060] Its preparation method is as follows:

[0061] (1) Preparation of capsule material:

[0062] Using gelatin, glycerin, titanium dioxide, bright black and water as raw materials, according to the weight ratio, gelatin: glycerin: titanium dioxide: bright black: water is 1: 0.4: 0.5: 0.05: 1, put the above materials into the interlayer tank and stir, steam heating Interlayer, after fully melting the material and keeping it warm for 1-2 hours, let it stand until the foam floats up, adjust the pH value of the solution to 5.0 with glacial acetic acid, keep warm at 60°C and filter, and prepare the glue for later use;

[0063] (2) Preparation of soft capsules:

[0064] a). Place the elemene, edible soybean oil, and Tween-80 of the prescribed amount in a suitable co...

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Abstract

The present invention is elemene soft capsule as one kind of antitumor medicine and its preparation process. The elemene soft capsule consists of capsule covering and inclusion. The inclusion includes elemene, vegetable oil and surfactant; and the capsule covering is made with adhesive, plasticizer, opacifier and water in the weight ratio of 1 to 0.3-0.45 to 0-1 to 0.7-1.4, and has pH value controlled in 5.0-7.0. The elemene soft capsule has the bad smell of elemene masked, and has high stability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a soft capsule preparation of the antineoplastic drug elemene and a preparation method thereof. The preparation is composed of a capsule material and contents, and the contents contain elemene, vegetable oil and surface active agent. Background technique [0002] Elemene is an effective component in the volatile oil extracted from the rhizome of Curcuma turmeric (commonly known as Curcuma wenensis), of which the sum of β-elemene, δ-elemene and γ-elemene accounts for more than 85%, so it is collectively called elemene Fragrantene. [0003] The traditional Chinese medicine Zedoary Curcuma is warm in nature and bitter in taste, has the function of removing blood stasis, promoting qi and relieving pain. In early herbal works such as "Kaibao Materia Medica" and "Taiming Materia Medica", there are records of Zedoary treating abdominal pain, blood stasis and internal damage. It can be s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/015A61K9/48A61P35/00
Inventor 刘玉辉谢瑞钢
Owner 刘玉辉
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