Microflow chip and method for preparing polymer microsphere using same
A technology of microfluidic chips and microspheres, which is applied in the direction of being fixed on/in an organic carrier, and transported in bulk, which can solve the problem of difficult organisms not to be damaged, the diameter of which cannot be precisely controlled, and the large size distribution of microspheres, etc. problems, to achieve uniform and controllable size, good forming, and good repeatability.
Inactive Publication Date: 2008-11-12
WUHAN UNIV
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Problems solved by technology
Preparation of polymeric microspheres by traditional methods either cannot precisely control the diameter, or the microspheres have a large size distribution, or require a large amount of reagents
Moreover, these traditional preparation methods make it difficult to keep the organism from being damaged when coating the organism
The diameter of monodisperse polymer microspheres currently prepared is generally distributed above 100 microns or below 10 microns, and it is difficult to prepare by traditional means between 10-100 microns
Method used
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[0011] Referring to the accompanying drawings, the microfluidic chip of the present invention includes a synthesis channel 2 and two flow focusing ball channels 1, the outlets of the two flow focusing ball channels 1 intersect at the entrance of the synthesis channel 2, each The flow focusing ball channel 1 is composed of a prepolymer microsphere channel 8, a dispersed phase channel 4 and two continuous phase channels 3, and the two continuous phase channels 3 are distributed on both sides of the dispersed phase channel 4 , the continuous phase channel 3, the dispersed phase channel 4 and the prepolymer microsphere channel 8 all have input ports 5, 6, 7 and outlets 9, 10, 11, the continuous phase channel 3 and the dispersed phase channel 4 The outlets 9 and 10 intersect at the input port 7 of the prepolymer microsphere channel 8, the diameter of the dispersed phase channel 4 is 30-500 microns, the diameter of the continuous phase channel 3 is 30-200 microns, and the prepolymer ...
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Abstract
The invention relates to a microflow chip comprising synthesized channel and two beam focusing ball tracks, in which two exits of beam focusing ball tracks converge at the entrance of the synthesized channel, each beam focusing ball track comprises prepolymer microsphere track, discontinuous phase track and two continuous phase channels, the said two continuous phase channels distribute on both sides of the discontinuous phase track, the prepolymer microsphere track, discontinuous phase track and continuous phase channels evenly have ingate and exit and the exits of the discontinuous phase track and continuous phase channels converge at the ingate of the synthesized channel. The invention also provides a method for preparing polymer microsphere using the said microflow chip: injecting two continuous phases from ingates of continuous phase channels of two beam focusing channels, injecting discontinuous phase from discontinuous phase channels of beam focusing channels, then obtaining polymer microsphere from the synthesized channel exit. The invention can exactly prepare controllable polymer microsphere with coincidence sizes.
Description
technical field [0001] The invention relates to a microfluidic chip and a method for preparing polymer microspheres by using the microfluidic chip, in particular to a micromachining design structure, which requires the design to conform to the principle of fluid dynamics, and belongs to the field of microfluidic chips. It can be applied to chemical synthesis to obtain polymer microspheres, which belongs to the field of chemical synthesis. Cells can also be added into biocompatible polymer microspheres to solidify into balls, which can be used as a favorable environment for cell culture, transfer, storage and analysis, and belong to the field of biological cytology. It can also be used in the field of drug sustained release to wrap drugs, and belongs to the field of biopharmaceuticals. Background technique [0002] Controllable polymer microspheres with a diameter of 10-100 μm have attractive potentials in biological, chemical, and medical applications. The traditional prep...
Claims
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IPC IPC(8): C12N11/08A61K9/16
Inventor 赵兴中刘侃
Owner WUHAN UNIV