The invention discloses a high-pressure disinfection and cleaning integrated machine. The high-pressure disinfection and cleaning integrated machine comprises an ozone generator, a conveying belt, a cleaning tank, high-pressure nozzles, a water tank body, a cleaning fluid storage tank, an ultrasonic generator and a filtering device, wherein the cleaning tank is arranged in the water tank body, an inlet and an outlet are arranged at two ends of the water tank body, and the conveying belt is arranged in the inlet and the outlet. With the adoption of the conveying belt, mutual collision and manual carrying of cleaning articles are avoided, the labor intensity is reduced, and the cleaning efficiency is increased; the high-pressure nozzles and the cleaning fluid storage tank are adopted for washing fruits and vegetables by the aid of water flow, the cleaning effect on the articles is improved, water recycling is realized, and energy is saved; by means of the ultrasonic generator, tiny bubbles are formed on the water surface and break instantly once meeting attachments, and the attachments on the surfaces of the articles fall off; the disinfection and sterilization functions are realized by the aid of the ozone generator, and the high-pressure disinfection and cleaning integrated machine is applicable to cleaning of the articles.