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An elemene formulation and preparation method thereof

A technology for elemene and preparations, applied in the field of elemene preparations and preparation thereof, can solve problems such as poor stability and irritating odor, and achieve the effects of low cost, improved curative effect, and favorable clinical application.

Inactive Publication Date: 2009-02-04
刘玉辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the defects such as poor stability, pungent smell, and easy side effects of existing elemene pharmaceutical preparations, and to prepare elemene preparations by using specific auxiliary materials, thereby solving the above problems and providing A kind of elemene preparation with good stability, no irritating smell, significant curative effect, which can be used for intravenous injection

Method used

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  • An elemene formulation and preparation method thereof
  • An elemene formulation and preparation method thereof
  • An elemene formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take 10 grams of elemene that meets China's "National Drug Standard ws-048(x-040) 96", polyoxyethylene castor oil-40 200 grams, mix and heat to 50-60 ° C, add polyethylene glycol-400 100 gram, 150 grams of Tween-80 and fully stirred until completely clear, then add 130ml of ethanol, after stirring evenly, add 1000ml of water for injection preheated to 50-60°C, stir at high speed until clear, filter with a 0.22μm microporous membrane, Fill and seal in ampoules, fill with nitrogen, melt seal, and steam sterilize for 30 minutes to obtain the product.

Embodiment 2

[0037] The raw materials used are the same as in Example 1. Weigh 20 grams of elemene, 200 grams of polyoxyethylene castor oil-40, mix and heat to 50-60 °C, add 100 grams of polyethylene glycol-400, 150 grams of Tween-80 Stir well until completely clear, then add 130ml of ethanol, stir evenly, add 1000ml of water for injection preheated to 50-60°C, stir at high speed until clear, filter with a 0.22μm microporous membrane, fill and seal in an ampoule, fill Nitrogen, sealing, steam sterilization for 30 minutes, that is.

Embodiment 3

[0039]The raw materials used are the same as in Example 1. Weigh 10 grams of elemene, 250 grams of polyoxyethylene castor oil-40, mix and heat to 50-60 °C, add polyethylene glycol-400 150 grams, Tween-80 200 grams Stir well until completely clear, then add 230ml of ethanol, stir evenly, add 1000ml of water for injection preheated to 50-60°C, stir at high speed until clear, filter with a 0.22μm microporous membrane, fill in an ampoule, fill Nitrogen, sealing, steam sterilization for 30 minutes, that is.

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Abstract

The invention relates to an elemene preparation having antiviral and anticancer actions and process for preparation, wherein the raw materials include elemene, polyethylene glycol 400, Tween 80, ethanol, polyoxyethylene castor oil 40, and water for injection. the preparation has good stability, no irritant odor, and substantial curative effects. The preparation can be administrated through injection or oral channel.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an elemene preparation with antiviral and anticancer effects and a preparation method thereof. The formulation can be administered by injection or orally. Background technique [0002] Elemene is an active ingredient extracted from Curcuma phaeocalis Valeton. or Curcumakwangsiensis S.GLee et C.F. from Guangxi or Curcuma Wenyujin Y.H.chen et C.Ling or other plants. Its English name is Elemene, and its chemical name is: 1-methyl-1-vinyl-2,4 diisopropenylcyclohexane, molecular formula: C 15 h 24 . Elemene contains a variety of isomers, mainly α-elemene, β-elemene, γ-elemene, δ-elemene, curcumene, and caryrone. There have been many literature reports on the method of extracting and refining elemene, as described in Chinese patent CN1060038 and Chinese patent CN1200266. [0003] Elemene is a volatile oil, which is a fat-soluble component, insoluble in water, and has a strong pungen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/015A61K9/08A61P31/12A61P35/00
Inventor 刘玉辉谢瑞钢
Owner 刘玉辉
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