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Process for preparing notoginseng diol saponin

A technology of diol saponins and alcohol saponins is applied in the field of preparation of extracting notoginseng glycol saponins from Panax notoginseng, and can solve the problems of the properties of notoginseng glycol saponins, the preparation method of pharmacological action, and the effects of human body, etc. The effect of low cost, stable quality and less loss

Active Publication Date: 2009-03-25
李明劲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] After many years of research, the inventors have found that many components in the total saponins of Panax notoginseng are ineffective for treating arthralgia syndrome in the human body, and those that are really effective are the saponins of notoginsengdiol, etc. The method and the effect on the human body have not been reported

Method used

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  • Process for preparing notoginseng diol saponin
  • Process for preparing notoginseng diol saponin
  • Process for preparing notoginseng diol saponin

Examples

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example 1

[0030] Example 1: Prepare according to the following steps:

[0031] 1. Take 100 grams of Panax notoginseng and crush it through the No. 1 sieve, add 60% ethanol to soak, percolate, and collect the percolate;

[0032] 2. Concentrate the percolate under reduced pressure at a temperature of 50°C to recover ethanol;

[0033] 3. Dilute the concentrated solution with distilled water to 500-600 ml, slowly add it to a macroporous adsorption resin separation column (the ratio of column diameter to column height: 30:160, with 100 ml of D101 resin inside), and then use 500 Milliliters of distilled water, 1000 milliliters of 40% ethanol and 1000 milliliters of 60% ethanol for elution, the flow rate is 0.5 times the bed volume / hour, and the 60% ethanol eluate is collected;

[0034] 4. The 60% ethanol eluate was concentrated under reduced pressure at a temperature of 50°C to a crude diol saponin solution with a relative density of 1.10;

[0035] 5. Mix the diol saponin crude product solu...

example 2

[0041] Example 2: Prepare according to the following steps:

[0042] 1. Take 50 grams of Panax notoginseng and crush it through the No. 1 sieve, add 60% ethanol to soak, percolate, and collect the percolate;

[0043] 2. Concentrate the percolate under reduced pressure at a temperature of 50°C to recover ethanol;

[0044] 3. Dilute the concentrated solution to 250-300 ml with distilled water, centrifuge and filter, and slowly add the aqueous solution to the macroporous adsorption resin separation column (the ratio of column diameter to column height: 30:160, with 40 ml of D101 resin inside) In, eluted with 200 milliliters of distilled water, 300 milliliters of 40% ethanol and 400 milliliters of 60% ethanol successively, the flow rate is 0.6 times bed volume / hour, collects 60% ethanol eluate;

[0045] 4. The 60% ethanol eluate was concentrated under reduced pressure at a temperature of 50°C to a crude diol saponin solution with a relative density of 1.10;

[0046] 5. Mix the d...

example 3

[0052] Example 3: Anti-inflammatory and Analgesic Effects of Notoginsengdiol Saponins

[0053] The test drug notoginsengdiol saponin was provided by the Phytochemical Department of Tianjin Pharmaceutical Research Institute as a light yellow-brown powder batch number 940201, with a content of R b1 =59.15 Rd=15.10%, before the test, it was prepared into a solution of the required concentration with distilled water, and it was given to the experimental animals for intragastric administration.

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Abstract

The invention discloses a process for preparing notoginseng diol saponin, which includes following steps: crushing the notoginseng, and adding ethanol solution whose concentration is 60% to immerse and percoalte the notoginseng, and then collecting the percoalted liquid and reducing pressure to concentrate the same, and then using distilled water to dilute the concentrated liquid, and then slowly filling the liquid into the large-hole absorption resin separating column, and using 60% ethanol to elute, and then collecting the 60% ethanol elutriant and then concentrating the same by reducing pressure to obtain panaxadiol saponin crude solution whose relative density is 1.10, and refining the same to obtain notoginseng panaxadiol saponin in light claybank powder form. The notoginseng panaxadiol saponin extracted by the provided process contains all glycols saponin in the notoginseng, and the extraction rate can reach 82 to 88%. The notoginseng panaxadiol saponin prepared by the provided process is the active component in notoginseng which can detumescence and analgecize, and has low toxicity, low cost, stable quality and high safety.

Description

field of invention [0001] The present invention relates to a method for extracting medicinal plants, more particularly to a method for preparing notoginseng diol saponins from Radix Notoginseng. Background technique [0002] Panax notoginseng has always been a famous and precious traditional Chinese medicine, which has the effect of dispelling blood stasis, stopping bleeding, reducing swelling and relieving pain. In traditional Chinese medicine compound prescriptions, especially the compound prescriptions for treating bruises, it is inseparable from it, such as Yunnan Baiyao, Shenqishangyao, Qili Scatter and so on. It is also commonly used in compound prescriptions with less medicinal taste in modern times, such as the famous compound Danshen Tablets (Sanqi, Danshen) dripping pills. [0003] Single-flavored traditional Chinese medicine is used alone, which is the "magic prescription" of the "seven prescriptions" of traditional Chinese medicine prescriptions. In traditional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00
Inventor 李明劲
Owner 李明劲
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