Fecal enterococcus CMS-II001 and its application

Abstract

The present invention discloses one kind of Enterococcus faecalis CMS-H001 in the preservation number of CCTCC No. M 206108. The Enterococcus faecalis CMS-H001 of the present invention may be used in treating Helicobacter pylori (HP) infection effectively.

Description

technical field The invention relates to the technical field of microorganisms, in particular to a new bacterial strain of Enterococcus faecalis and the application of the bacterial strain. Background technique Helicobacter pylori (Helicobacter pylori, HP) infection is one of the most common human infections, with an infection rate of more than 50% in the global population. Since Warren and Marshall successfully cultured Helicobacter pylori from human gastric mucosa specimens in 1982 and identified HP as the pathogenic bacterium of gastritis and peptic ulcer, it has changed the history of chronic gastritis, peptic ulcer, and gastric mucosa-associated lymphoma (MALT). ) treatment and prevention pattern of gastric cancer, the above four diseases have been designated as HP-related diseases. A large number of studies have shown that HP infection is the main cause of chronic active gastritis and peptic ulcer, and is closely related to gastric cancer and gastric mucosa-associated...

AI Technical Summary

Problems solved by technology

Although it is very effective to suppress and kill HP with antibiotics at present, the cost is relatively expensive, and people must bear the harm caused by antibiotics.

With the widespread use of antibiotics in combination, HP drug-resistant strains will increase, and the types, time and amount of antibiotics used will increase, which will cause the following hazards: 1. A large number of long-term and combined with multiple antibiotics, the toxic and side effects on the human body will be reduced. 2. The strain variation and drug-resistant strains increase, and the mutated strains will not be limited to HP; 3. The microecology of other cavities and skin is destroyed, resulting in the reduction of the self-purification function of each cavity, causing other mucosal atrophy-related diseases and even Increased incidence of tumors

The combination of a large number of antibiotics will cause a series of problems such as antibiotic-associated diarrhea, intestinal flora imbalance, and even pseudomembranous colitis, which will reduce the curative effect, reduce patient compliance, and easily relapse and reinfection after drug withdrawal, and The rapid increase of drug-resistant strains further reduces the eradication rate

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