Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics

A hydroxyl and compound technology, applied in the application field of compounds of general formula and pharmaceutical compositions, can solve the problems of efficiency and application limitations, the inability of protein growth factors to penetrate various biological barriers, and low bioavailability
CN100519546CInactive Publication Date: 2009-07-29CENT NAT DE LA RECHERCHE SCI +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CENT NAT DE LA RECHERCHE SCI
Publication Date
2009-07-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to any isolated or synthetic compound, in particular a compound of general formula (I), which is capable of modulating the cellular specialization of neural stem cells, favoring the differentiation and subsequent survival of neurons and glial cells during differentiation. and differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the compounds according to the invention are able to reduce inflammatory substances in diseases affecting the nervous system, in particular by reducing the activation of microglia and / or astrocytes and / or by reducing reactive gliosis. The present invention also relates to a method for preparing the compound and the use of the compound in the preparation of a pharmaceutical composition for the prevention or treatment of diseases affecting the nervous system. More specifically, the compounds of the present invention have the following general formula (I).
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Description

technical field

[0001] The present invention relates to any isolated or synthetic compound, especially a compound of general formula (I), capable of regulating the cell specialization of neural stem cells (regulation of neuron / glial cell ratio), promoting neuronal and glial cell differentiation during differentiation. Glial cell differentiation and subsequent survival and differentiation of oligodendrocyte precursor cells to mature oligodendrocytes. In addition, the compounds according to the invention are able to reduce inflammatory substances in diseases affecting the nervous system, in particular by reducing the activation of microglia and / or astrocytes and / or by reducing reactive gliosis. The invention also relates to compositions comprising these compounds as well as processes for their preparation and their use in the preparation of pharmaceutical compositions for the prevention or treatment of diseases affecting the nervous system. Background technique

[0002] The c...

Claims

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