Microorganism metabolism control of actinoplanes species

A technology of microbial metabolism and swimming actinomycetes, applied in the direction of microorganisms, microorganisms, and methods based on microorganisms, can solve the problems of shortened product synthesis stages, high nutrient concentration, and reduced output of metabolites, and achieve easy industrialization The effect of high production and fermentation level and low production cost
CN100519732CActive Publication Date: 2009-07-29HUADONG MEDICINE +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUADONG MEDICINE
Publication Date
2009-07-29

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Abstract

The invention discloses a method for preparing high-unit acarbose by regulating the microbial metabolism of actinomycete Actinoplanes species. The invention adopts a computer automatic variable speed feeding method to start feeding after 40-48 hours of microbial fermentation, and feed 3 times per minute. -4L feed liquid; continue until 84-92 hours to adjust the feeding amount to 1-2L feed liquid per minute. The acarbose prepared by the method of the invention has a high fermentation level, saves raw materials, has low production cost, does not need to modify original equipment, and is easy for industrialized production.
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Description

technical field

[0001] The invention relates to the field of biochemical industry, and more specifically relates to a method for preparing high-unit acarbose by regulating microbial metabolism. Background technique

[0002] Acarbose, chemical name: O-4,6-dideoxy-4-[(1S,4R,5S,6S)4,5,6-trihydroxy-3-(hydroxymethyl)-2 -Cyclohexenyl-1-amino]-a-D-glucopyranosyl-(1→4)—O—a—D-glucopyranosyl—(1→4)-D-glucopyranosyl, which is composed of free The metabolites produced by Actinoplanes species. are mainly used in the treatment of type II diabetes.

[0003] In the industry, acarbose is prepared by regulating the microbial metabolism of Actinoplanes species, that is, by fermentation. The feeding method generally adopted in the microbial fermentation method is periodic feeding, feeding once every other day, and a fermentation cycle takes about 8 days, that is, feeding 3-4 times in a fermentation cycle. This feeding method has great disadvantages. Because it is a one-time supplement of carb...

Claims

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