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Preparation and application of dragon blood medicinal composition

A technology of composition and dried blood, which can be used in drug combination, medical preparations containing active ingredients, blood diseases, etc., and can solve the problems of poor water solubility and poor absorption.

Inactive Publication Date: 2009-08-05
胡少勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the specific treatment, dried blood dried powder is taken with water, but blood dried blood is not only poor in water solubility, but also has strong hydrophobicity, and the drug is poorly absorbed after entering the body. If a more advanced preparation carrier is used, it will be better. Play the therapeutic effect of blood exhaustion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, dry suspension preparation of dried blood composition 1

[0013] Preparation prescription:

[0014] Dracaena 1000g main ingredient

[0015] Gum Arabic 62g Suspending Agent

[0016] Xanthan Gum 77g Suspending Agent

[0017] Sodium Carboxymethyl Cellulose 41g Suspending Agent

[0018] Sucrose 1200g Bulking agent

[0019] Tween 80 20g Solubilizer

[0020] Sweet Orange Flavor 22g Flavoring

[0021] Make 1000 bags

[0022] Preparation method: according to the above preparation prescription, take the main drug dragon's blood, mix it evenly with sucrose, gum arabic, sodium carboxymethyl cellulose, xanthan gum, and sweet orange essence, granulate with an appropriate amount of 75% ethanol, dry, granulate, divide Put it on and get it.

[0023] Quality inspection: The sedimentation volume ratio is 0.92, which meets the requirements of the Pharmacopoeia.

Embodiment 2

[0024] Embodiment 2, dry suspension preparation of dried blood composition 2

[0025] Preparation prescription:

[0026] Dracaena phospholipid complex 1875g main drug (Dragon's blood-phospholipid 4:1)

[0027] Polyvinylpyrrolidone 100g Suspending Agent

[0028] Hydroxypropyl Methyl Cellulose 40g Suspending Agent

[0029] Sodium Carboxymethyl Starch 30g Suspending Agent

[0030] Micronized Silica Gel 210g Glidant

[0031] Sodium Saccharin 1.1g Flavoring

[0032] Mannitol 300g bulking agent

[0033] Make 1000 bags

[0034] Preparation method: Prepare Dracaena phospholipid complex according to the method described in Chinese patent CN 1583139 A; take Dracaena phospholipid complex, add other preparation auxiliary materials, pass through a 100-mesh sieve, mix evenly, and pack separately to obtain.

[0035] Quality inspection: The sedimentation volume ratio is 0.94, which meets the requirements of the Pharmacopoeia.

Embodiment 3

[0036] Embodiment 3, dry suspension preparation of dried blood composition 3

[0037] Preparation prescription:

[0038] Hainan dried blood (micronized) 600g main ingredient

[0039] Xanthane Gum 35g Suspending Agent

[0040] Colloidal silicon dioxide 15g

[0041] Micronized silica gel 100g Glidant

[0042] Make 1000 bags

[0043] Preparation method: according to the above prescription, take Hainan dried blood and carry out micronization treatment, and the processed dried blood can pass through a 300-mesh sieve; take the rest of the excipients and pass through a 200-mesh sieve, mix the main drug and the excipients evenly, and pack them separately to obtain .

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Abstract

The invention discloses a dried blood pharmaceutical composition, which is composed of blood dried blood and excipients with suspending effect, and a blood dried blood preparation carrier (immediate release) made from the composition. The preparations made of the above pharmaceutical composition include dry suspension and effervescent, which have the characteristics of quick release and high bioavailability, can fully exert the therapeutic effect of blood dryness, and are convenient to use and carry, and patient medication compliance Good features.

Description

technical field [0001] The invention relates to a dried blood preparation with improved curative effect. The specific carrier is a dry suspension and an effervescent preparation, which is very convenient for patients to take and carry. Background technique [0002] Dried blood, formerly known as Qilin dried, has been used as a precious traditional Chinese medicine for 1,500 years. Dried blood has the functions of promoting blood circulation and removing blood stasis, removing putrefaction and promoting muscle growth, and stopping bleeding and sores. After the 1970s, domestic dried blood was successfully developed in Yunnan, Guangxi, and Hainan, and domestic dried dried blood began to gradually replace imported dried dried blood. The results of chemical, pharmacodynamic, toxicological and clinical research in the past 20 years showed that domestic dried dried blood has The indicators have all reached the standards of imported dried blood. Domestic dried blood is also called d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K36/889A61P7/04A61P17/02A61K131/00
Inventor 胡少勇
Owner 胡少勇