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Freeze-drying powder injection for treating calor febrilis and its production

A freeze-dried powder injection and high-heat technology, applied in the field of freeze-dried powder injection and its preparation, can solve the problems of poor clarity, increase the risk of clinical medication, deepening of color, etc., achieve good stability, ensure drug efficacy and clarity Good results

Active Publication Date: 2009-08-12
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Rekeping injection has antipyretic effect and can be used to treat high fever caused by general high fever, influenza, malaria or other viral diseases. The clinical effect is very good, but it has the defects of deepening color and poor clarity during long-term storage , increasing the risk of clinical use

Method used

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  • Freeze-drying powder injection for treating calor febrilis and its production
  • Freeze-drying powder injection for treating calor febrilis and its production
  • Freeze-drying powder injection for treating calor febrilis and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: the preparation of freeze-dried powder injection

[0053] Take 275g of Bupleurum bupleurum and 275g of goose not eating grass, add water and soak for 24 hours, distill, collect 50 times the distillate, redistill the distillate once, collect 900ml of distillate, add 10ml of polysorbate 80, 100g of mannitol, and use 0.05 % Activated carbon is heated to adsorb pyrogens, decarbonized, add water for injection to 1000ml, stir well, adjust the pH value to 5.5, filter with a 0.22μm filter membrane, fill 2ml into a 5ml vial, freeze-dry, tie the cap, that is have to.

Embodiment 2

[0054] Embodiment 2: the preparation of freeze-dried powder injection

[0055] Take 275g of Bupleurum bupleurum and 275g of goose not eating grass, soak in water for 24 hours, distill, collect 50 times the amount of distillate, redistill the distillate once, collect 900ml of distillate, add 10g of hydroxypropyl β-cyclodextrin, mannitol 100g, heated with 0.05% activated carbon to adsorb pyrogen, decarbonized, added water for injection to 1000ml, stirred well, adjusted pH value to 5.5, filtered with 0.22μm filter membrane, filled 2ml into 5ml vials, freeze-dried, Zhagai, that is to say.

Embodiment 3

[0056] Embodiment 3: the preparation of freeze-dried powder injection

[0057] Take 275g of Bupleurum bupleurum and 275g of goose not eating grass, soak in water for 24 hours, distill, collect 50 times the amount of distillate, redistill the distillate once, collect 900ml of distillate, add 20g of hydroxypropyl β-cyclodextrin, and 100g of lactose , use 0.05% activated carbon to heat and adsorb pyrogens, decarbonize, add water for injection to 1000ml, stir well, adjust the pH value to 5.5, filter with a 0.22μm filter membrane, fill 2ml into a 5ml vial, freeze-dry, prick Cover and serve.

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Abstract

The invention relates to a freeze-dried powder injection and a preparation method thereof. The freeze-dried powder injection is composed of the distillate of Bupleurum chinensis and goosebud herbivory, polysorbate 80 and mannitol. The preparation method is as follows: take 200-350 parts by weight of Bupleurum chinensis and 200-350 parts by weight of goose not eating grass, add water and soak for 12-36 hours, distill, collect 40-60 times the distillate, redistill the distillate once, collect Distillate 500-1500 parts by volume, add 10-30 parts by volume of polysorbate 80, 50-150 parts by weight of mannitol, heat with 0.01-1.0% activated carbon to absorb pyrogen, decarbonize, and then add water for injection to 500-1500 Volume parts, stir well, adjust the pH value to 4.5-6.5, filter through a 0.22 μm filter membrane, fill, freeze-dry, and tie the cap to obtain the freeze-dried powder injection.

Description

technical field [0001] The invention relates to a freeze-dried powder injection and a preparation method thereof, in particular to a freeze-dried powder injection for treating high fever caused by general high fever, influenza, malaria or other viral diseases and a preparation method thereof. Background technique [0002] The functions and indications of Rekeping Injection are: antipyretic, anti-inflammatory and analgesic. It is suitable for fever caused by infectious diseases and non-infectious diseases. The main indications are: [0003] 1. Fever caused by bacterial, viral, or parasitic infections (cold, wound infection, pneumonia, pleurisy, malaria, etc.). [0004] 2. Fever caused by postoperative tissue damage, internal bleeding, and extensive burns. [0005] 3. Fever caused by tissue necrosis and cell destruction (tumor, leukemia, hemolysis, etc.). [0006] 4. Fever caused by endocrine and metabolic disorders (hyperthyroidism, severe dehydration, etc.). [0007] 5....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K36/28A61K36/233A61P29/00A61P31/00
Inventor 胡思玉张德奎
Owner SICHUAN KELUN PHARMA CO LTD
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