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Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein

A technology of disposal system and drug delivery device, which is applied in the fields of nervous system diseases, organic active ingredients, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2009-08-12
EURO-CELTIQUE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Inadvertent and / or deliberate misuse and / or abuse of transdermal delivery devices remains a major health concern

Method used

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  • Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
  • Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
  • Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] In Example 1, the transdermal applicator was loaded with buprenorphine (BUP) as shown in FIG. 2B . The specific BUP TDD used in Example 1 was similar in composition to those marketed in Europe under the trade name TRANSTEC by Gruenenthal of Switzerland, but it only contained a total BUP dose of 20 mg (and therefore had a different surface area than the commercially available TDD). The BUP TDD was then fixed and isolated using the TDD disposal system as shown in Figure 1B. The amount of BUP extractable (and thus potentially available for abuse) in some cases from the TDD contained in the TDD disposal system was then determined by extraction using the following solvents: distilled water, tap water, 0.026 M sodium bicarbonate in water, 5 % vinegar, acetone, methanol, ethanol, ethyl acetate or ether. Extraction was performed under the following extraction conditions: after 5 min, 60 min and 120 min in the extraction solvent at room temperature of about 25°C. For each extr...

Embodiment 2

[0175] For the pilot Example 2, the transdermal applicator was loaded with BUP as shown in Figure 2B, as in Example 1. The BUP TDD was then fixed and isolated using the TDD disposal system as shown in Figure 1C. The amount of BUP extractable (and thus potentially available for abuse) in some cases from the TDD contained in the TDD disposal system was then determined by extraction using the following solvents: distilled water, tap water, 0.026M aqueous sodium bicarbonate, 5% vinegar, acetone, methanol, ethanol, ethyl acetate and / or diethyl ether. Extraction was performed under the following extraction conditions: room temperature at about 25°C, and after 5 min, 60 min and 120 min in the extraction solvent at reflux (ie, at about the boiling temperature of the extraction solvent). For each extraction solvent, the TDD exists in the following isolated state: (1) the first substrate (i.e., pasted to the TDD) is not pasted on the second substrate (adhesive side of the sticking devi...

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Abstract

The present invention relates to a transdermal delivery device disposal system for disposing of a transdermal delivery device containing at least one pharmaceutically active component. The disposal system contains at least one sheet or substrate on which an adhesive is coated; and one or more of the following components: (a) monomer, and optionally comonomer(s), to be polymerized; (b) an initiator, and optionally co-initiator(s), to initiate the polymerization; (c) at least one crosslinking agent to crosslink the (co)polymer; and (d) at least one deactivating agent to chemically alter, to degrade, and / or to deactivate the active component(s) contained in the transdermal delivery device, such as an opioid antagonist or an opioid agonist deactivating agent so that the euphoric effects of the active component(s) contained in the transdermal delivery device are at least temporarily inhibited, diminished, or halted in vivo , wherein at least one adhesive-coated sheet or substrate adheres to, immobilizes, or isolates, and prevents, inhibits, or diminishes the misuse or abuse of the active component contained in, at least one transdermal delivery device.

Description

technical field [0001] The present invention relates to a disposal system for preventing, inhibiting and / or reducing deliberate and / or inadvertent misuse or abuse of a transdermal drug delivery device ("TDD") containing an active agent such as an opioid. The present invention also relates to disposing of TDD and and / or ways to prevent misuse or abuse of TDD or any component of TDD. Background technique [0002] Transdermal dosage forms are convenient dosage forms for the administration of many different active therapeutically effective agents, including but not limited to analgesics such as opioid analgesics. Typical opioid analgesics include, but are not limited to, fentanyl, buprenorphine, etorphine, and other potent narcotics. Other therapeutically effective agents that can be administered using transdermal delivery systems include, but are not limited to, antiemetics (scopolamine), cardiovascular agents (nitrates and clonidine), hormones (estrogen and testosterone), nic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K9/70A61K31/445B09B3/00A61F13/00A61K31/4535A61K47/32A61K47/34
CPCA61K9/7023B09B2220/14B09B3/0075A61K31/485A61K31/445A61P25/04A61P25/36B09B2101/68A61K9/00A61K9/70
Inventor C·J·贝克I·舍夫丘克
Owner EURO-CELTIQUE SA
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