Method for synthesizing akarol fenisobromolate

Abstract

The invention provides a method for synthesizing bromofen, which uses glyoxylic acid as the starting material, and first conducts condensation reaction with bromobenzene to obtain 4,4'-dibromodiphenylacetic acid, which is mixed with isopropanol The esterification reaction is carried out to obtain 4,4'-dibromodiphenylacetic acid isopropyl ester, and the generated ester is catalyzed and oxidized with oxygen in the presence of a catalyst to obtain the bromofen. The beneficial effects of the present invention are mainly reflected in: short synthetic route, high yield, low cost, high product purity, and favorable industrial production.

Description

(1) Technical field

[0001] The invention relates to a synthetic method of bromofen, an acaricide, in particular to a synthetic method of bromofen with glyoxylic acid as the main raw material. (2) Background technology

[0002] The chemical name of bromofen is 4,4'-dibromodiphenylglycolic acid isopropyl ester, the structural formula is shown in formula (I), and the molecular formula is: C 17 h 16 Br 2 o 3 , is a low-toxic, high-efficiency, broad-spectrum acaricide with strong contact activity and long-lasting effect. It has good contact effect on adults, nymphs and eggs, and the temperature change has little effect on the efficacy. It is widely used in fruit trees, vegetables, tea, cotton and farmland crops to prevent and control various harmful mites such as spider mites, gall mites, barb mites, and nematodes. Due to the unique mechanism of action of bromofen, its usage is gradually expanding.

[0003]

[0004] The industrialized synthesis process mainly includes the...

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