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Compound Chinese traditional medicine for treating neuropathic pain

A technology of neuropathy and compound medicine, applied in nervous system diseases, medical formulas, drug combinations, etc., can solve the problem of no safe and effective traditional Chinese medicine formula for neuropathic pain, achieve good application prospects, facilitate administration, and reduce adverse reactions.

Inactive Publication Date: 2009-12-30
司马蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no safe and effective traditional Chinese medicine formula for the treatment of neuropathic pain.

Method used

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  • Compound Chinese traditional medicine for treating neuropathic pain
  • Compound Chinese traditional medicine for treating neuropathic pain
  • Compound Chinese traditional medicine for treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The influence of embodiment 1 Chinese medicine on mechanical stimulation sensory hypersensitivity

[0032] 1 Materials and methods

[0033] (1) Experimental animals, drugs and instruments

[0034] Wistar rats: Provided by Weitong Lihua Animal Experiment Center, 30 healthy females, weighing 190-230g. Compound traditional Chinese medicine: 12g of Dragon's Blood, 15g of Duhuo, 15g of Guanzhong, 15g of Dilong, 15g of Liu Jinu, 30g of Raw Astragalus mixed with water at a ratio of 1:100, decocted for 3 hours, filtered the decoction, and then added at a concentration of 1%. A high-efficiency transdermal agent, azone laurate. Von Frey filaments: North Coast Medical, USA. BME-410C Automatic Thermal Pain Stimulator: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences. YLS-3E electronic tenderness instrument: Shandong Academy of Medical Sciences.

[0035] (2) SNL model establishment and experimental grouping

[0036]Rats were acclimatized to the new envi...

Embodiment 2

[0048] The influence of embodiment 2 Chinese medicine on mechanical stimulation hyperesthesia

[0049] 1 material and method (with embodiment 1)

[0050] 2 results

[0051] Pain behavior in the SNL group was stable and persisted until the end of the experiment. After 2 weeks of treatment, the TWL of the Chinese medicine group was prolonged, and there was a significant difference compared with the SNL group until the end of the experiment, P<0.01 (Table 2).

[0052] Table 2 Changes in threshold of mechanical paw withdrawal reflex (X±S) (g)

[0053]

[0054] *Compared with SNL group, P<0.01

Embodiment 3

[0055] The influence of embodiment 3 Chinese medicines on thermal stimulation hypersensitivity

[0056] 1 material and method (with embodiment 1)

[0057] 2 results

[0058] Pain behavior in the SNL group was stable and persisted until the end of the experiment. After 1 week of treatment, the TWL of the Chinese medicine group was prolonged, and there was a significant difference compared with the SNL group until the end of the experiment, P<0.01 (Table 3).

[0059] Table 3 Latency change of heat withdrawal reflex (X±S) (g)

[0060]

[0061] *Compared with SNL group, P<0.01

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Abstract

Disclosed is an externally-used compound Chinese medicament for treating pains caused by nervous diseases, which is prepared from dragon's blood resin, pubescent angelica root, basket fern, earthworm, ragwort and raw astragalus root, and has the advantages of convenient administration and less adverse effect.

Description

a technical field [0001] The invention relates to a compound traditional Chinese medicine for external use, in particular to a traditional Chinese medicine which can effectively treat neuropathic pain. Two background technology [0002] Pain is generally divided into nociceptive pain and neuropathic pain. Neuropathic pain (Neuropathic pain) refers to the long-term transmission of pain signals due to the disturbance of nerve conduction pathways, resulting in the enhancement of the degree of pain perception and the prolongation of the duration of pain perception. The characteristics of pain include prolongation and intensity of pain caused by noxious stimuli (Hypergesia), pain caused by non-painful stimuli (Allodynia), spontaneous pain (Spontaneous pain), and may be accompanied by sympathetic nerve dysfunction such as Symptoms such as edema and abnormal sweating. Common neuropathic pain is peripheral or central nervous system injury (phantom limb pain, stump pain, spinal cor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61K36/481A61K36/282A61K36/232A61K36/11A61K35/64A61K9/08A61P25/04A61K35/62
Inventor 司马蕾贾立群
Owner 司马蕾