Triamcinolone benetonide local film forming gel composition

Abstract

The present invention discloses a kind of locally filming triamcinolone benetonide gel composition comprising hydroxyalkyl cellulose 0.5-7 wt%, esterifying agent 1-10 wt%, crosslinknig agent 0.5-5 wt%, solvent 75-90 wt% and triamcinolone benetonide 0.01-3 wt%, where, the crosslinknig agent is saturated fatty polyol or alcoholic acid in the general expression of CnH2n+2-m-l(OH)m(COOH)l, with n, m and l being integral numbers. The locally filming triamcinolone benetonide gel composition is used in treating oral cavity ulcer, skin ulcer, eczema, etc. through spreading to the surface of oral cavity or skin to form one layer of smooth hydrophobic protecting film with long retention time.

Description

technical field [0001] The invention relates to a triamcinolone acetonide local film-forming gel composition. Background technique [0002] Oral mucosa / skin ulcers, or skin eczema are common diseases that people often encounter in daily life. The topical pharmaceutical preparations clinically used to treat oral mucosa / skin ulcers or skin eczema are usually pastes, gargles, intraoral creams, creams, ointments, gels, etc., when these preparations are applied on the oral mucosa or skin When performing local treatment, due to the normal activities of the treatment site and surrounding tissues, such as friction, secretion and washing of body fluids and saliva, these agents will be dissolved and / or eroded, shifted, and fall off, and the agent and the treatment site will remain for a short time. The residence time of the oral mucosa generally does not exceed 15 minutes, and the residence time on the skin surface does not exceed 30 minutes, which significantly reduces the curative ...

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear, and its effective residence time on the oral mucosa is only 3 to 4 hours

[0007] Therefore, if the technology of the above-mentioned existing film-forming gel composition is used to prepare triamcinolone acetonide local film-forming gel, the retention time of the medicament and the affected part will be shorter, and the therapeutic effect will be lower. Membrane gel product launch

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