Radix sileris total chromone extractive and its preparation method

A technology of extract and chromone, applied in the field of medicine

Inactive Publication Date: 2007-07-18
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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So far, there are no patents related to the total chromone extract of Fangfeng and its preparation method and use

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  • Radix sileris total chromone extractive and its preparation method

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Embodiment 1

[0039] Example 1: Preparation process of Fangfeng Total Chromone

[0040] Take 1kg of Fangfeng decoction pieces, extract 3 times with 10L of 70% ethanol under reflux, extract for 1 hour each time, and recover the solvent under reduced pressure to obtain the extract, add water to disperse and dissolve, so that the concentration of the aqueous solution is 3.84mg / mL (based on the total chromone content) , centrifuged at 3000 rpm for 30 min, took the supernatant, passed it through 5L AB-8 macroporous adsorption resin, the adsorption flow rate was 1.0mL / min, the ratio of diameter to height of the resin column was 1:8, and the loading volume was 7.68 mg / min. mL (based on total chromone content), 10% ethanol elutes 2 times the resin volume for impurity removal, the impurity removal flow rate is 1.0mL / min, 70% ethanol elutes 5 times the resin volume, and the elution flow rate is 2.0mL / min min, collect the 70% ethanol eluate, recover the solvent, and dry under reduced pressure, which i...

Embodiment 2

[0041] Example 2: Preparation process of Fangfeng total chromone

[0042] Fangfeng decoction pieces 1kg, 50% ethanol 15L, reflux extraction 3 times, 1.5 hours each time, recover the solvent, add water to disperse and dissolve the extract, make the concentration of the aqueous solution 3.00mg / mL (based on the amount of total chromone), at 3000 rpm Centrifuge for 30min at a speed of 1 / min, take the supernatant, and pass through 6L AB-8 macroporous adsorption resin, the adsorption flow rate is 1.0mL / min, the diameter-height ratio of the resin column is 1:7, and the sample loading is 7.00mg / mL (based on the total Chromone meter), 10% ethanol elutes 2 times of resin volume to remove impurities, and the flow rate of impurity removal is 1.0mL / min, 50% ethanol elutes 4 times of resin volume, the elution flow rate is 2.0mL / min, collects 50 % ethanol eluent, recover the solvent, and dry under reduced pressure, which is the total chromogenone extract of Radix Radix Radix. The total chro...

Embodiment 3

[0043] Example 3: Preparation process of Fangfeng total chromone

[0044] Fangfeng decoction pieces 1kg, 70% ethanol 12L reflux extraction 2 times, each extraction 2 hours, recover the solvent, add water to disperse and dissolve the extract, so that the concentration of the aqueous solution is 4.00mg / mL (based on the amount of total chromone), at 3000 rpm Centrifuge at a speed of 1 minute for 30 minutes, take the supernatant, and pass through 7L AB-8 macroporous adsorption resin, the adsorption flow rate is 1.0mL / min, the diameter-height ratio of the resin column is 1:9, and the sample loading is 8.00mg / mL (based on total color Protoketone meter), water eluted 4 times the resin volume for impurity removal, the impurity removal flow rate was 1.0mL / min, 90% ethanol eluted 4 times the resin volume, the elution flow rate was 2.0mL / min, collected 90% ethanol wash The liquid is removed, the solvent is recovered, and dried under reduced pressure, which is the total chromone extract o...

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Abstract

A general chromone extract of ledebouriella root includes proportionally cimifugin, 5-0-methylwestammiol, etc. It is prepared by solvent extracting method or macroreticular adsorption resin method.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a total chromogen extract of the traditional Chinese medicine Fangfeng, a preparation method, a quality control method and its application in the fields of medicine and health food. Background technique [0002] Fangfeng is a commonly used traditional Chinese medicine, derived from the dried roots of Saposhnikovia divaricata (Turcz.) Schischk. and other plants of the same genus. The traditional Chinese medicine theory believes that Fangfeng has the functions of relieving the exterior and dispersing wind, eliminating dampness and relieving pain, dispelling wind and relieving convulsions, and mainly treating exogenous wind-cold, headache, dizziness, pain all over the body, wind-cold-damp arthralgia, joint pain, limb spasm and other syndromes, modern pharmacological research It has been shown that Fangfeng has various effects such as antipyretic, analgesic, anti-inflamm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/238A61K9/00C07D493/04
Inventor 刘斌石任兵姜艳艳
Owner 石任兵
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