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Plaster for treating hepatitis B, and its preparing method

A technology of hepatitis B and patch, applied in the field of patch with picroside II monomer as the active ingredient and its preparation, and patch for treating hepatitis B, which can solve the problem of the unseen literature on picroside II patch Reporting and other problems, to overcome the short half-life of drugs, easy to carry, and low production costs

Active Publication Date: 2010-06-02
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are a lot of literature reports about the patch both at home and abroad, but there is no literature report about the Pibroside II patch for the treatment of hepatitis

Method used

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  • Plaster for treating hepatitis B, and its preparing method
  • Plaster for treating hepatitis B, and its preparing method
  • Plaster for treating hepatitis B, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Formula: Pipericillin II monomer 1%

[0091] Matrix 64%

[0092] Penetration enhancer 35%

[0093] The weight ratio of each component in the matrix is: carbopol: low molecular weight sodium polyacrylate: high molecular weight sodium polyacrylate=2:15:20.

[0094] The weight ratio of the components of the penetration enhancer is: 5% azone: 10% 1,2-propanediol=1:1.

[0095] Take berberine II monomer, add it into the matrix prepared according to the prescription, stir evenly, then add compound penetration enhancer, and stir evenly. The patch was prepared by extrusion coating method. 10cm 2 Cut / piece and pack.

Embodiment 2

[0097] Formula: Pipericillin II monomer 25%

[0098] Matrix 40%

[0099] Penetration enhancer 35%

[0100] The weight ratio of each component in the matrix is: carbopol: low molecular weight sodium polyacrylate: high molecular weight sodium polyacrylate: citric acid: aluminum chloride = 4: 12: 24: 1: 1.44.

[0101] The weight ratio of the components of the penetration enhancer is: 5% azone: 10% 1,2-propanediol=1:3.

[0102] Take berberine II monomer, add it into the matrix prepared according to the prescription, stir evenly, then add compound penetration enhancer, and stir evenly. The patch was prepared by extrusion coating method. 20cm 2 Cut / piece and pack.

Embodiment 3

[0104] Formula: Pipericillin II monomer 20%

[0105] Matrix 50%

[0106] Penetration enhancer 30%

[0107] The weight ratio of each component in the matrix is: carbopol: low molecular weight sodium polyacrylate: high molecular weight sodium polyacrylate: citric acid=6:10:30:1.

[0108] The weight ratio of the components of the penetration enhancer is: 5% azone: 10% 1,2-propanediol=1:1.5.

[0109] Take berberine II monomer, add it into the matrix prepared according to the prescription, stir evenly, then add compound penetration enhancer, and stir evenly. The patch was prepared by extrusion coating method. 5cm 2 Cut / piece and pack.

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Abstract

A medicine in the form of paster for treating hepatitis B is composed of a substrate layer, a matrix layer containing kutkoside B, matrix and osmosis promoter, and a protective layer.

Description

field of invention [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a patch for treating hepatitis B, in particular to a patch with berberine II monomer as an active ingredient and a preparation method thereof. Background technique [0002] Liver disease is one of the diseases that endanger human health, especially hepatitis B, which is easy to develop into cancerous lesions, and has always been one of the key research and breakthrough topics in the medical field for many years. At present, there is no specific drug for the clinical treatment of hepatitis B. Antiviral drugs such as acyclovir and interferon are mostly used. Long-term medication is required in the treatment of hepatitis B. Western medicines have large side effects and interferon is expensive. For hepatitis B symptoms and medication Due to the population size characteristics, it is imminent to choose a drug that is convenient to use, has good curat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/70A61P1/16A61P31/20
Inventor 周亚伟王文蜀
Owner 北大世佳科技开发有限公司