Compound paracetamol injection for livestock and process for preparing same
A technology for acetaminophen and injections, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of reducing curative effect, improve survival rate, and have wide clinical applications , the effect of weight gain
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Embodiment 1
[0016] Embodiment 1 (every portion is 500g)
[0017] Compound paracetamol injection: 110 parts of paracetamol, 20 parts of diclofenac sodium, 300 parts of polyethylene glycol-400 (PEG-400), 300 parts of propylene glycol, and 20 parts of sodium bisulfite.
[0018] Made in the following way:
[0019] (1) Weigh 110 parts of paracetamol, 20 parts of diclofenac sodium, 300 parts of polyethylene glycol-400 (PEG-400), 300 parts of propylene glycol, and 20 parts of sodium bisulfite;
[0020] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;
[0021] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;
[0022] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a kind of co...
Embodiment 2
[0023] Embodiment 2 (every portion is 1500g)
[0024] Compound paracetamol injection, 50 parts of paracetamol, 10 parts of diclofenac sodium, 100 parts of polyethylene glycol-400 (PEG-400), 100 parts of propylene glycol, and 10 parts of sodium bisulfite.
[0025] Made in the following way:
[0026] (1) Take by weight 50 parts of paracetamol, 10 parts of diclofenac sodium, 100 parts of polyethylene glycol-400 (PEG-400), 100 parts of propylene glycol, and 10 parts of sodium bisulfite;
[0027] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;
[0028] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;
[0029] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a ki...
Embodiment 3
[0030] Embodiment 3 (every portion is 2500g)
[0031] Compound paracetamol injection, 120 parts of paracetamol, 20 parts of diclofenac sodium, 350 parts of polyethylene glycol-400 (PEG-400), 350 parts of propylene glycol, and 30 parts of sodium bisulfite.
[0032] Made in the following way:
[0033] (1) Weigh 120 parts of paracetamol, 20 parts of diclofenac sodium, 350 parts of polyethylene glycol-400 (PEG-400), 350 parts of propylene glycol, and 30 parts of sodium bisulfite;
[0034] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;
[0035] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;
[0036] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a kind of c...
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