Compound paracetamol injection for livestock and process for preparing same

A technology for acetaminophen and injections, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of reducing curative effect, improve survival rate, and have wide clinical applications , the effect of weight gain

Inactive Publication Date: 2007-08-15
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, due to long-term and repeated use of single antipyretic, analgesic and anti-inflammatory drugs, pathogenic microorganisms have developed resistance to the drugs, and the curative effect has been reduced.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 (every portion is 500g)

[0017] Compound paracetamol injection: 110 parts of paracetamol, 20 parts of diclofenac sodium, 300 parts of polyethylene glycol-400 (PEG-400), 300 parts of propylene glycol, and 20 parts of sodium bisulfite.

[0018] Made in the following way:

[0019] (1) Weigh 110 parts of paracetamol, 20 parts of diclofenac sodium, 300 parts of polyethylene glycol-400 (PEG-400), 300 parts of propylene glycol, and 20 parts of sodium bisulfite;

[0020] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;

[0021] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;

[0022] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a kind of co...

Embodiment 2

[0023] Embodiment 2 (every portion is 1500g)

[0024] Compound paracetamol injection, 50 parts of paracetamol, 10 parts of diclofenac sodium, 100 parts of polyethylene glycol-400 (PEG-400), 100 parts of propylene glycol, and 10 parts of sodium bisulfite.

[0025] Made in the following way:

[0026] (1) Take by weight 50 parts of paracetamol, 10 parts of diclofenac sodium, 100 parts of polyethylene glycol-400 (PEG-400), 100 parts of propylene glycol, and 10 parts of sodium bisulfite;

[0027] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;

[0028] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;

[0029] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a ki...

Embodiment 3

[0030] Embodiment 3 (every portion is 2500g)

[0031] Compound paracetamol injection, 120 parts of paracetamol, 20 parts of diclofenac sodium, 350 parts of polyethylene glycol-400 (PEG-400), 350 parts of propylene glycol, and 30 parts of sodium bisulfite.

[0032] Made in the following way:

[0033] (1) Weigh 120 parts of paracetamol, 20 parts of diclofenac sodium, 350 parts of polyethylene glycol-400 (PEG-400), 350 parts of propylene glycol, and 30 parts of sodium bisulfite;

[0034] (2) Mix the polyethylene glycol-400 and propylene glycol and heat to 70-80°C, add the diclofenac sodium and stir until clear; then add the paracetamol and stir until clear;

[0035] (3) Take another 200 parts of water for injection and heat to 30-40°C; add the sodium bisulfite and stir until clear;

[0036] (4) Combine the solution obtained in step (2) and step (3), adjust the pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and add water for injection to 1000 parts to make a kind of c...

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PUM

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Abstract

The invention discloses a compound acetaminophen injection for livestock and its preparation method. the injection comprises acetaminophen 50-200, diclofenac sodium 10-50, polyethylene glycol-400 100-500, propylene glycol 100-500, and sodium bisulfite 10-30. the preparation method comprises (1) mixing polyethylene glycol-400 and propylene glycol, heating to 70-80deg.C, adding diclofenac sodium, stirring, adding acetaminophen, stirring; (2) heating water for injection to 30-40deg.C, adding sodium bisulfite, stirring; and (3) merging the solutions of steps 1 and 2, adjusting pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and adding water for injection to 1000 to obtain the final product. The invention strengthen antipyretic and analgesic effects, is effective for treating pain and fever due to different kinds of inflammation, and can improve animal survival rate and increase animal body weight.

Description

technical field [0001] The invention relates to the field of drug injections, in particular to a compound acetaminophen injection for livestock and a preparation method thereof. Background technique [0002] Livestock high fever is one of the most common diseases, which seriously restricts the development of breeding industry. Over the past decades, due to long-term repeated use of single antipyretic, analgesic and anti-inflammatory drugs, pathogenic microorganisms have developed resistance to the drugs, and the curative effect has been reduced. Contents of the invention [0003] The purpose of the present invention is to expand the antipyretic and analgesic range and effect of the drug, and to provide a compound acetaminophen for livestock that avoids repeated use of an antipyretic, analgesic and anti-inflammatory drug, and makes pathogenic microorganisms resistant to drugs. Injection and its preparation method. [0004] The compound paracetamol injection of the present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61K9/08A61K47/34A61P29/00A61K31/167A61K47/10
Inventor 魏宗生郭建华耿强斌
Owner TIANJIN SHENGJI GRP CO LTD
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