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Application of non-depolarizing muscular relaxant in preventing and eliminating facial wrinkles

A technology for eliminating facial wrinkles and depolarization, which is applied in the field of anti-wrinkle compositions and its preparation, can solve problems such as the toxic and side effects of botulinum toxin, and achieve the effects of eliminating wrinkles, strongly maintaining facial skin moisture, and eliminating or preventing facial wrinkles

Inactive Publication Date: 2007-08-22
沈赞 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the toxic side effects of botulinum toxin, there are many cases of fever, fatigue, and poor appetite after injection.

Method used

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  • Application of non-depolarizing muscular relaxant in preventing and eliminating facial wrinkles

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0043] Preparation of anti-wrinkle composition

[0044] (1) Deionized pure water is used as a solvent, wherein hyaluronic acid is firstly added at a concentration of 0.5 g / L.

[0045] (2) Add hydrolyzed gelatin 30g / L; place the mixed solution in a warm water bath at 37°C and shake gently for 30 minutes. After the solution is completely clear and transparent, take it out and cool it to room temperature. After cooling, the solution forms a gel.

[0046] (3) Add the non-depolarizing muscle relaxant vecuronium bromide to the above gel at a concentration of 0.1 g / L, and stir well.

[0047] (4) Finally, add XF-1 anti-mildew, anti-corrosion and fungicide, mix thoroughly, and store in a dark place at low temperature.

preparation example 2

[0049] Preparation of anti-wrinkle composition

[0050] (1) Deionized pure water is used as a solvent, wherein hyaluronic acid is firstly added at a concentration of 4 g / L.

[0051] (2) Add 200g / L hydrolyzed gelatin; place the mixed solution in a warm water bath at 45°C and shake gently for 60 minutes. After the solution is completely clear and transparent, take it out and cool it to room temperature. After cooling, the solution forms a gel.

[0052] (3) Add non-depolarizing muscle relaxant rocuronium bromide to the above gel at a concentration of 1.0 g / L, and stir well.

[0053] (4) Finally, add XF-1 anti-mildew, anti-corrosion and fungicide, mix thoroughly, and store in a dark place at low temperature.

preparation example 3

[0055] Preparation of anti-wrinkle composition

[0056] (1) Deionized pure water is used as a solvent, wherein hyaluronic acid is firstly added at a concentration of 2 g / L.

[0057] (2) Add 80g / L of hydrolyzed gelatin; place the mixed solution in a warm water bath at 60°C and shake gently for 45 minutes. After the solution is completely clear and transparent, take it out and cool it to room temperature. After cooling, the solution forms a gel.

[0058] (3) Add pipecuronium bromide, a non-depolarizing muscle relaxant, to the above gel at a concentration of 0.4 g / L, and stir and mix well.

[0059] (4) Finally, add XF-1 anti-mold, anti-corrosion and fungicide, and mix well. Store at low temperature in the dark.

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PUM

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Abstract

The present invention discloses the application of non-depolarizing muscular relaxant in preventing and eliminating facial wrinkles and one kind of wrinkle resisting composite containing non-depolarizing muscular relaxant. The wrinkle resisting composite includes effective components, which comprises non-depolarizing muscular relaxant 0.1-1.0 weight portions, hyaluronic acid 0.5-4 weight portions and gelatin hydrolysate 30-200 weight portions; pharmaceutically acceptable supplementary material. The present invention can prevent and eliminate facial wrinkles effectively.

Description

technical field [0001] The invention relates to the application of non-depolarizing muscle relaxants in preventing and eliminating facial wrinkles, and a composition containing non-depolarizing muscle relaxants for anti-wrinkle and a preparation method thereof. Background technique [0002] From the point of view of medical histology, wrinkles are caused by the degeneration and atrophy of elastic fibers, connective tissue and skin fibers in the dermal tissue of the skin, as well as the reduction of moisture, fat and subcutaneous fat in the epidermis and dermis. There are many causes of wrinkles, such as: [0003] Frequent facial muscle movements, such as raising the head, laughing, frowning, and wrinkling the nose, can also easily promote the formation of wrinkles. [0004] As people age, muscle strength decreases, facial muscles become weak, and skin tension decreases, resulting in wrinkles. [0005] Loss of water in the epidermis. During adolescence, the cells in the ep...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/63A61K31/58A61Q19/00A61P21/02
Inventor 沈赞郑静汤谷平
Owner 沈赞
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