Method for detecting Tadalafei and derivative thereof

A technology for tadalafil and its derivatives, which is applied in the field of detection of tadalafil and its derivatives, can solve the problems of lack of inspection equipment, difficulty in screening, and inability to identify new derivatives, and achieve strong specificity, sensitive response, The effect of high accuracy
CN101021483AActive Publication Date: 2007-08-22BEIJING INST FOR DRUG CONTROL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INST FOR DRUG CONTROL
Publication Date
2007-08-22
Patent Text Reader

Abstract

The invention discloses a method to detect Tadalafil and its derivative. It contains steps: (1) Color reaction. Make color reaction by adding concentrated sulfuric acid. (2) Result estimation. If color reaction presents blue violet, there are Tadalafil and its derivative in test samples. The method has merits of quick, simple, high sensitivity and strong property etc.
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Description

technical field

[0001] The invention relates to a method for detecting tadalafil and its derivatives. Background technique

[0002] Tadalafil is a second-generation phosphodiesterase inhibitor developed by Eli Lilly and Company of the United States. It is clinically used to treat male erectile dysfunction (ED). Its structural formula is shown in formula I, and its molecular formula is C 22 h 19 N 3 o 4 , the trade name is Cialis, which is a prescription drug. Compared with the other two drugs for treating ED, sildenafil and vardenafil, tadalafil has a rapid onset of action and a long duration of action. It has been detected in food, aphrodisiac Chinese medicine preparations or health food for many times, and even The detection of its derivatives is self-evident to the harm of uninformed consumers, and also caused confusion in the market of traditional Chinese medicine preparations and health food.

[0003] (Formula I)

[0004] At present, there is no rapid test metho...

Claims

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