Loratadine dispersible tablets and its preparing method

A technology of loratadine and dispersible tablets, which is applied in the field of loratadine dispersible tablets for the treatment of allergic diseases and its preparation, and can solve the problems of slow onset of action, inability to quickly absorb the drug, and inconvenient taking.

Inactive Publication Date: 2007-08-29
BEIJING SL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current loratadine is generally an oral gastric solution, the drug cannot be absorbed quickly, the onset is...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, Loratadine dispersible tablet preparation, each specification is 10mg

[0036] Take by weighing the raw materials needed for preparing 1000 loratadine dispersible tablets: 10.0 g of loratadine, 76.0 g of lactose microcrystalline cellulose, 3.6 g of pregelatinized starch, 12.0 g of sodium carboxymethyl starch, 6.0 g of aspartame g, sodium lauryl sulfate 1.2g, magnesium stearate 1.2g.

[0037] Prepare as follows:

[0038] (1) The loratadine is pulverized and passed through a 100-mesh sieve, the microcrystalline fiber is passed through a 80-mesh sieve, and the magnesium stearate is passed through a 60-mesh sieve. The remaining auxiliary materials are passed through a 40-mesh sieve. spare.

[0039] (2) Sodium lauryl sulfate and loratadine are mixed uniformly to obtain mixture I.

[0040] (3) Carboxymethyl starch sodium and mixture I are mixed uniformly to obtain mixture II.

[0041] (4) Mix aspartame and pregelatinized starch evenly and pass through a 20-...

Embodiment 2

[0048] Embodiment 2, Loratadine dispersible tablet preparation, each specification is 5mg

[0049] Take by weighing the raw materials needed for preparing 1000 loratadine dispersible tablets: loratadine 5.0g, lactose microcrystalline cellulose 76.0g, pregelatinized starch 3.6g, carboxymethyl starch sodium 12.0g, aspartame 6.0 g, sodium lauryl sulfate 1.2g, magnesium stearate 1.2g.

[0050] Prepare as follows:

[0051] (1) The loratadine is pulverized and passed through a 100-mesh sieve, the microcrystalline fiber is passed through a 80-mesh sieve, and the magnesium stearate is passed through a 60-mesh sieve. The remaining auxiliary materials are passed through a 40-mesh sieve. spare.

[0052] (2) Sodium lauryl sulfate and loratadine are mixed uniformly to obtain mixture I.

[0053] (3) Carboxymethyl starch sodium and mixture I are mixed uniformly to obtain mixture II.

[0054] (4) Mix aspartame and pregelatinized starch evenly and pass through a 20-mesh sieve to obtain mi...

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PUM

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Abstract

The present invention relates to a loratadine dispersion tablet and its preparation method. Its dispersion tablet prescription contains 30-80 wt% of avicel or lactose, 2-10 wt% of pre-gelled starch, 1-20 wt% of carboxymethyl starch sodium or polyvinylpyrrolidone or their mixture, 1-10 wt% of aspartame, 0.5-2 wt% of sodium lauryl sulfate and 0.5-2 wt% of magnesium stearate. Said dispersion tablet can be used for curing the diseases of allergic rhinitis, chronic urticaraia, titillation dermatosis and other allergic dermatosis, etc.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a loratadine dispersible tablet for treating allergic diseases and a preparation method thereof. Background technique [0002] Allergy is also known as allergic reaction, which is called antigen-antibody reaction in modern medicine. Allergic reactions are divided into 4 types, and the most common clinical type is type I, also known as immediate hypersensitivity reactions. Histamine is one of the important mediators of type I allergic reactions. With the change of human living environment and the increase of allergens, the incidence of allergic diseases tends to increase. Type I allergic reactions are common in people with allergic constitutions. They are mostly caused by exposure to pollen, dust, food, drugs, etc. The pathogenesis is that the allergens enter the body and combine with the cell surface and IgE, causing the cells to be injured and release a large amount of hist...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K9/20A61K47/36A61K47/34A61K47/38A61P37/08A61P11/02A61P17/00A61P17/04
Inventor 徐明波李学海王勇波李亚军齐燕明杨仲璠周伟赵紫岭邵兵王俊玲倪娜连治国梁果义何耀强吴彦卓
Owner BEIJING SL PHARMA
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