Process for producing shikimic acid

A production process, shikimic acid technology, applied in the field of shikimic acid production process, can solve the problems of complex process, large solvent consumption, low work efficiency, etc., achieve high content of active ingredients, reduce production cost, and improve work efficiency Effect

Inactive Publication Date: 2010-07-07
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical Problem In order to overcome the disadvantages of complex process, excessive solvent consumption, many types of organic solvents, serious cross-mixing, low raw material utilization rate, high cost and low work efficiency in the existing traditional technology, the present invention provides a Convenient and effective shikimic acid production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1500kg star anise dried fruit (shikimic acid content is 3.69%) is crushed to a particle size of 20-30 mesh and placed in a percolation tank. According to the mass ratio of material: water = 1:3, water is passed into the material and heated under normal pressure Soak the material at a temperature of 75°C for 1 hour, turn on the motor to circulate for 15 minutes, and then soak for 1 hour. Repeat this 5 times. After soaking and extracting for 7 hours, after concentrating the percolate in the internal circulation concentration tank, the specific gravity is 1.15, weight It is 45.7kg shikimic acid crude product extract.

[0023] 2. While hot, mix the crude extract of shikimic acid according to the ratio of materials: silica gel = 1:1, stir evenly, cool to dryness, and use it to load and inject samples through the chromatographic column.

[0024] 3 Put the cooled, dried and stirred silica gel samples on the upper ends of 6 chromatographic columns with an inner diameter of 40cm...

Embodiment 2

[0029] 150kg star anise dried fruit (content is 3.69%) is pulverized to the particle size of passing 20~30 mesh and is placed in the percolation tank, according to material: solvent=1: 3 mass ratio, water is passed in the material, and the water temperature is heated under normal pressure to Soak the material at 75°C for 1 hour, turn on the motor to circulate for 15 minutes, and then soak for 1 hour. Repeat this 5 times. After soaking and extracting for 7 hours, after concentrating the percolate in the internal circulation concentration tank, the specific gravity is 1.15 and the weight is 5.7kg. shikimic acid crude extract.

[0030] 2. While hot, mix the crude shikimic acid extract according to the ratio of material: silica gel = 1:1, stir evenly, cool to dryness, and use it to load and inject the sample through the chromatography column.

[0031] 3 Put the cooled, dried and stirred silica gel samples on the upper end of a chromatographic column with an inner diameter of 40cm,...

Embodiment 3

[0036] 1200kg star anise dried fruit (content is 3.69%) is pulverized to the particle size of passing 20~30 mesh and is placed in the percolation tank, presses material: solvent=1: 3 mass ratio, water is passed in the material, under normal pressure, heat water temperature to Soak the material at 75C for 1 hour, turn on the motor for 15 minutes, and then soak for 1 hour. Repeat this 5 times. After soaking and extracting for 7 hours, after concentrating the percolate in the internal circulation concentration tank, the specific gravity is 1.15 and the weight is 20.2kg. Crude shikimic acid extract.

[0037]2. While hot, mix the crude extract of shikimic acid according to the ratio of materials: silica gel = 1:1, stir evenly, cool to dryness, and use it to load and inject samples through the chromatographic column.

[0038] 3 Put the cooled, dried and stirred silica gel samples on the upper ends of three chromatographic columns with an inner diameter of 40cm, the sample thickness ...

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Abstract

The invention supplies a shikimic acid producing method that includes the following steps: adding water into raw material chinese anise, taking recycling for 6-8 hours at 50-80 degree centigrade, concentrating to skikimic acid extractive raw material; mixing and whisking raw material and silica gel according to 1:1, leaching by ethyl acetate, testing and collecting eluate, concentrating and filtering to gain shikimic primary crystallization, taking recrystallization by using the same method. The invention sharply simplifies distilling process, improves working efficiency, decreases producing cost, and could shikimic acid of 90-95% purity.

Description

technical field [0001] The invention relates to a convenient and effective shikimic acid production process, in particular to a method for directly extracting shikimic acid from plants. Background technique [0002] Shikimic acid is a cyclic organic acid present in natural plants such as star anise and some gymnosperms, and it is the main active ingredient in the traditional Chinese medicine star anise. After years of research, it has been shown that it has the functions of dissolving thrombosis, analgesia and antitumor. As an intermediate of chemical synthesis, shikimic acid is not only commonly used in analgesic, anticancer and antithrombotic drugs, but also in the synthesis of insecticides and antibacterial agents. With the widespread prevalence of avian influenza in the world in recent years, natural shikimic acid has become an essential raw material for the synthesis of Tamiflu, a highly curative human avian influenza, and has become very popular and its price has soare...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C62/04C07C51/42A61K36/57A61K131/00
Inventor 何新华刘兆普刘玲赵耕毛章睿琳章贻琴
Owner NANJING AGRICULTURAL UNIVERSITY
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