Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Liquid composition containing biphenyldimethy-dicarboxylate mutual soluble with water

A bifendate and solution technology, applied in the field of liquid pharmaceutical compositions, can solve the problems of reduced patient compliance, inconvenience in taking bifendate drop pills, etc., and achieves guaranteed bioavailability and is suitable for large Industrial production, the effect of simple production process

Inactive Publication Date: 2007-10-03
刘瑜玲
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with hepatitis need to take medicine for a long time, and the small-sized bifendate pills are relatively inconvenient to take, which also reduces the patient's compliance to a certain extent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liquid composition containing biphenyldimethy-dicarboxylate mutual soluble with water
  • Liquid composition containing biphenyldimethy-dicarboxylate mutual soluble with water

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of Bifendate Solution System

[0038] Weigh 7.5g of the bifendate raw drug, add it into a container filled with 1000ml PEG-400 solution, and stir until it is completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

Embodiment 2

[0040] Preparation of Bifendate Solution System

[0041] Weigh 7.5g of the bifendate raw drug, add 1.5g of Tween 80, mix well, add PEG-400 to 500ml, and stir until completely dissolved; you can also dissolve Tween 80 in the PEG-400 solution first, and then add Bifendate raw drug, stirred until completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

Embodiment 3

[0043] Preparation of Bifendate Solution System

[0044] Weigh 7.5 g of the bifendate raw drug, add it to a container containing 1000 ml of ethylene glycol monoethyl ether (Transcutol), and stir until it is completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A liquid composition of bifendate mutually soluble with water is prepared from the bifendate difficult to dissolve, polyethanediol or ethanediol monoethyl ether, and solubilizer.

Description

technical field [0001] The invention relates to pharmaceutical preparation technology, in particular to a pharmaceutical composition in liquid form of the drug bifendate for treating hepatitis. Background technique [0002] Bifendate is a synthetic analogue of schisandra propionin with the chemical structure of 4,4'-dimethoxy-5,6,5',6'-dimethoxy-2,2'-dicarboxylate Esterbiphenyl (referred to as bifendate), which is clinically used for the treatment of chronic and persistent hepatitis, belongs to the national essential medicine. Animal experiments have proved that bifendate can significantly reduce the high serum alanine aminotransferase (SGPT) caused by various chemical poisons such as carbon tetrachloride and thioacetamide, and at the same time reduce the pathological damage of the liver without obvious toxic effects. It has been further clinically proven that the drug has a strong effect on lowering SGPT, and while the SGPT is lowered, the patient's subjective symptoms hav...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/36A61K9/48A61K9/08C07D317/48
Inventor 刘瑜玲苗弈
Owner 刘瑜玲
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com