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Medicinal composition for treating dysmenorrhea and preparation process thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formulation, drug delivery, etc., to achieve the effect of concentrated active ingredients, reduced usage, and simple ingredients

Active Publication Date: 2007-10-31
HUNAN KELUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the synergistic and synergistic effects of angelica polysaccharides and angelica volatile oil and the improvement of clinical dosage forms still need to be further improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: the preparation of granule

[0058] Preparation of Angelica polysaccharide: Radix Angelica sinensis was extracted 3 times with 8 times the weight of distilled water, 4 hours each time, after the 3 extractions were combined, concentrated by distillation under reduced pressure, after the concentrated solution was pre-cooled, 3 times the volume of ethanol was added, stirred, After standing still, collect the precipitate with a high-speed refrigerated centrifuge to obtain crude polysaccharides, dissolve the crude polysaccharides in distilled water, dialyze against distilled water at 4°C for 3 days, remove the precipitates by centrifugation, and freeze-dry the supernatant to obtain the product.

[0059] Preparation of Angelica volatile oil: take root powder of Angelica sinensis, put it in an extractor, add 6 times the weight part of hexane to soak overnight, extract on a constant temperature water bath for 16 hours, recover the solvent, and obtain the product. ...

Embodiment 2

[0061] Embodiment 2: the preparation of capsule

[0062] Angelica polysaccharide 48g Angelica volatile oil 12g, angelica volatile oil was clathrated with 180kgβ-cyclodextrin, after the obtained clathrate was mixed evenly with angelica polysaccharide, conventional excipients were added, granulated with 70% ethanol in a conventional manner, dried, and packed into 1000 capsules , that is.

Embodiment 3

[0063] Embodiment 3: the preparation of tablet

[0064] Angelica polysaccharide 30kg Angelica volatile oil 30kg, angelica volatile oil was clathrated with 90kgβ-cyclodextrin, after the obtained clathrate was mixed with angelica polysaccharide evenly, conventional excipients were added, granulated with 70% ethanol in a conventional manner, dried, and 0.5kg hard Magnesium fatty acid is mixed evenly and compressed into tablets.

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Abstract

The invention relates to a pharmaceutical composition for treating dysmenorrhea and process for preparation, wherein the composition is prepared from Chinese angelica polysaccharide and Chinese angelica volatile oil, wherein the content of Chinese angelica polysaccharide is higher than 50% calculated by glucose when measuring through phenol-sulfuric acid process, and when measuring through vapor phase chromatography process, the content of Chinese angelica polysaccharide is higher than 20% calculated by ligustilide. The invention also provides the process for preparing the oral preparation and injection, and the use of the pharmaceutical composition in preparing medicament for treating menorrhalgia.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation process thereof, in particular to a pharmaceutical composition for treating dysmenorrhea and a preparation process thereof. Background technique [0002] Dysmenorrhea refers to women's pain in the lower abdomen or waist, or even the lumbosacral area, during menstruation and before and after. At present, it is often divided into primary and secondary clinically. Primary dysmenorrhea refers to those without obvious lesions in the reproductive organs, and it is more common in adolescent girls, unmarried and married without children. Secondary dysmenorrhea is mostly caused by organic lesions in the reproductive organs. [0003] Simple Western medicine treatment of this disease, currently mostly use steroid hormone drugs to suppress ovulation, and prostaglandin antagonists, antispasmodic and analgesic drugs, although these methods can obtain curative effect, but hormone drugs are easy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K9/00A61K9/08A61K9/16A61K9/20A61K9/48A61P15/00
Inventor 王利春梁隆程志鹏
Owner HUNAN KELUN PHARMA
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