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Process for preparing particles for Zhizhu

A preparation process and granule technology, which is applied in the field of preparation process of Zhizhu granules, can solve the problem of cooling the extraction container, and achieve the effect of low paste yield, good stability and good curative effect

Active Publication Date: 2007-10-31
NANJING ZHONGSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the original Zhizhu pill preparation technology, this preparation method has been greatly improved, but the selection of extraction solvent is critical when microwave extraction is used, and the extracted substance must absorb microwaves, and the extraction container needs to be cooled. Extraction of volatile parts

Method used

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  • Process for preparing particles for Zhizhu
  • Process for preparing particles for Zhizhu

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Take 40 parts of fried Atractylodes macrocephala, 20 parts of fried Citrus aurantium, and 6 parts of lotus leaves, and prepare them by the following steps:

[0118] (1) Crush: Crush the fried Atractylodes macrocephala and Fructus Citrus aurantium into 20-mesh coarse powder for later use.

[0119] (2) CO 2 Supercritical extraction: Take the mixed coarse powder of fried Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome and Fructus Citrus Fructus Citrifolia in the extraction kettle, heat the extraction kettle and the analysis kettle until the predetermined temperature is reached, and send them into a certain flow rate of CO 2 Gas, adjust the pressure of each kettle and start the circulation extraction, wherein the temperature of the extraction kettle is 60 ° C, the pressure is 36Mpa, CO 2 The flow rate is 27L / h, the extraction time is 0.5 hour, and the extract in the separation tank is collected f...

Embodiment 2

[0126] Take 40 parts of fried Atractylodes macrocephala, 20 parts of fried Citrus aurantium, and 6 parts of lotus leaves, and prepare them by the following steps:

[0127] (1) Grinding: Grinding fried Atractylodes macrocephala and Fructus Citrus Fructus into 40-mesh fine powder for later use.

[0128] (2) CO 2 Supercritical extraction: Take the mixed fine powder of fried Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome and Fructus Citrus Fructus Citrifolia in the extraction kettle, heat the extraction kettle and the analysis kettle until the predetermined temperature is reached, and then send into a certain flow rate of CO 2 Gas, adjust the pressure of each kettle and start the circulation extraction, wherein the temperature of the extraction kettle is 40 ° C, the pressure is 30Mpa, CO 2 The flow rate was 24 L / h and the extraction time was 1.0 hour.

[0129] (3) Water extraction: take the CO2 The su...

Embodiment 3

[0135] Take 40 parts of fried Atractylodes macrocephala, 20 parts of fried Citrus aurantium, and 6 parts of lotus leaves, and prepare them by the following steps:

[0136] (1) Grinding: Grinding the fried Atractylodes macrocephala and Fructus Citrus Fructus into 60-mesh fine powder for later use.

[0137] (2) CO 2 Supercritical extraction: Take fried Atractylodes macrocephala and fried citrus aurantium fine powder in the extraction kettle, heat the extraction kettle and the analysis kettle to reach the predetermined temperature, and send it into a certain flow rate of CO 2 Gas, adjust the pressure of each kettle and start to circulate the extraction, wherein the temperature of the extraction kettle is 50 ° C, the pressure is 33Mpa, CO 2 The flow rate was 30 L / h, and the extraction time was 0.75 hours.

[0138] (3) Water extraction: take the CO 2 The supercritically extracted fried Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylod...

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Abstract

The invention discloses a preparing craft of citrus atractylodes rhizome particle, which comprises the following steps: supercritical-extracting parched white atractylodes rhizome and parched citrus; getting extractive benzine; producing extract inclusion compound with beta-cyclodextrin; aqueous-extracting with medical slag of supercritical extract and lotus leaf; getting aqueous-extracting liquid; condensing with penetrate liquid of film separation; cubing with extract beta-cyclodextrin inclusion compound, right amount dextrin and sweet chrysanthemum glycosides boiling spray; getting the product. This particle possesses good curative effect and good stability.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a preparation process of Zhizhu granules. Background technique [0002] Zhizhu granule is a classic Chinese patent medicine. The prescription was originally derived from Zhizhu decoction in Zhang Zhongjing's "Synopsis of the Golden Chamber. The Syndrome and Syndrome of Water and Qi Diseases". It is composed of three traditional Chinese medicines, namely Zhishi, Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome and lotus leaf, which were recorded in "Medical Qiyuan". Zhang Dongyuan, a disciple of Zhang Yuanyuan, included this prescription in "On Distinguishing Puzzles from Internal and External Injuries", "On Spleen and Stomach. Diet Injury to the Spleen" and "Lan Shi Mi Zang. On Deficiency of the Spleen and Stomach". The prescription of this medicine is reasonable and the compatibility is streamlined , The ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/899A61K9/16A61P1/14
Inventor 濮存海尹慧晶赵开军王波陈磊
Owner NANJING ZHONGSHAN PHARM CO LTD
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