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Preparation technology of children cold relaxation grain

Xiaoer Ganmaoshu Granules and preparation technology, which is applied in the field of preparation technology of Xiaoer Ganmaoshu Granules, can solve the problems of catmint oil with strong irritating smell, unsuitability for industrialized large-scale production, and large variable yield of volatile oil, etc., and achieve product quality Stable and controllable, shortened production cycle, and improved quality control

Active Publication Date: 2011-08-17
NANJING ZHONGSHAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, there are many deficiencies in the original Xiao'er Ganmaoshu granule process: (1) the steam distillation method is used to extract the nepeta volatile oil, the yield of the volatile oil is variable, and the nepeta oil has a strong pungent smell, and the children's compliance is poor; 2) Water precipitation method, using paraffin adsorption in the extract solution to degrease the burdock fruit, the efficiency is low and the degreasing is incomplete; (3) the extraction process is complicated, the production process is long, and the yield of paste is high, which is not suitable for industrialized large-scale production

Method used

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  • Preparation technology of children cold relaxation grain
  • Preparation technology of children cold relaxation grain
  • Preparation technology of children cold relaxation grain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132]Recipe: Pueraria 400g, Nepeta 300g, Campanulaceae 250g, Scrophulariae 150g, Licorice 100g, Cicada slough 200g, Jianqu 300g, Arctium 300g.

[0133] Preparation Process:

[0134] Mix kudzu root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and arctium evenly, grind them into coarse powder, add 1 times the total weight of medicinal materials in ethanol with a mass percentage concentration of 70%, soak for 6 hours, and then wash with The percolation rate per kilogram of medicinal material 6mL / min percolates, collects the percolation liquid of 5 times of the weight of the percolation medicinal material, and dries the leachate into an extract; mix fine powder of sucrose and dextrin (dextrin by weight: sucrose =1:4) mixed as a spray granulation carrier, the extract was spray granulated; when the primary air inlet temperature was 110°C, the material temperature was 55~65°C, and the speed of the peristaltic pump was 20rph, Xiaoermaoshu granules were obtai...

Embodiment 2

[0136] Recipe: Pueraria 300g, Nepeta 400g, Campanulaceae 300g, Scrophulariae 100g, Licorice 150g, Cicada slough 300g, Jianqu 400g, Arctium 400g.

[0137] Preparation Process:

[0138] Mix kudzu root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and arctium evenly, grind into coarse powder, add 1 times the total weight of medicinal materials to soak in 80% ethanol for 10 hours, and then add 14 mL / kg medicinal materials Min percolation speed percolation, collect the percolation liquid of 3 times of the total weight of the percolation medicinal materials, and dry the percolation liquid into extractum; mix fine powder of sucrose powder and dextrin (dextrin by weight: sucrose=1: 4) As a spray granulation carrier, the extract is sprayed and granulated, and dried to obtain it; when the primary air inlet temperature is 110°C, the material temperature is 55-65°C, and the speed of the peristaltic pump is 20rph, Xiaoermaoshu Granules are prepared .

Embodiment 3

[0140] Recipe: Pueraria 500g, Nepeta 200g, Campanulaceae 150g, Scrophulariaceae 200g, Licorice 50g, Cicada slough 150g, Jianqu 200g, Arctium 200g;

[0141] Preparation Process:

[0142] Mix kudzu root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and arctium evenly, pulverize into coarse powder, add 90% ethanol of 1 times the total weight of medicinal materials and soak for 8 hours, and then use 8mL / kg of medicinal materials Min percolation speed percolation, collect the percolation liquid which is 4 times the total weight of the percolation medicinal materials; take the percolation liquid and perform ultrafiltration at 25°C, the ultrafiltration membrane pore size is 50nm, and the membrane area is 0.2m 2 , in the ultrafiltration process, collect the ultrafiltrate of the percolation liquid amount of 1 times the total weight of the percolation medical material; then concentrate the ultrafiltrate into an extract with a relative density of 1.20 at 80 ° C; ...

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Abstract

The invention discloses a preparation technology of children cold relaxation grains, which comprising the following steps: extracting radix puerariae, herba schizonepetae, platycodon grandiflorum, figwort, liquorice, cicada slough, massa medicata fermentata and burdock in a diacolation way; and then preparing the children cold relaxation grains in a spraying way. The preparation technology has simple and stable production and controllable quality standard; and in addition, the children cold relaxation grains prepared by the technology are effective in treatment.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation process of Xiaoer Ganmaoshu Granules. Background technique [0002] Exogenous fever in children is the most common disease in children, and the incidence rate accounts for the first of pediatric diseases. At present, traditional Chinese medicines for treating colds are mainly divided into two categories. The first category is heat-clearing and detoxifying, such as Folium Folium Isatidis, Radix Isatidis, Forsythia, etc. These are the majority. Those with obvious symptoms of toxic heat; the second category belongs to the pungent and warm category, such as Qianghuo, Fangfeng, Nepeta, etc., which are suitable for those who suffer from cold and evil, which is a minority. According to Professor Jiang Yuren's clinical experience, the actual condition of the clinical manifestations of children with upper cold is not simply a matter of cold a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/808A61K9/16A61P29/00A61P31/00A61P11/00A61K35/64
Inventor 濮存海李鑫鹏赵开军王波陈磊徐云辉
Owner NANJING ZHONGSHAN PHARMA CO LTD
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