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Gel preparation for treating subacute eczema and chronic eczema, and preparation method

A gel preparation, a technology for chronic eczema, applied in the field of gel preparations, can solve problems such as poor curative effect, drug resistance, inability to cure, and achieve the effects of enhancing skin immune function, improving curative effect, and having no toxic and side effects

Inactive Publication Date: 2007-12-26
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, anti-allergic, sedative, hormone and other drugs are mostly used in the clinical treatment of these diseases, such as Piyanping, Daknine, etc., which have a certain effect on patients with a short duration of illness and mild symptoms, but for patients with a long course of disease and substandard symptoms. The curative effect of patients with acute eczema and chronic eczema is poor and cannot be cured, and some patients will develop drug resistance after long-term medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Prescription: evening primrose oil 79g, notopterygium extract 29g, vitamin E 9.9g, carbomer 9.9g, glycerin 49g, polysorbate 1.9g, absolute ethanol 49.9g, triethanolamine, water;

[0047] Preparation:

[0048] Take the coarse powder of notopterygium medicinal materials, add 8 times the amount of water to soak for 40 minutes, extract the volatile oil of notopterygium by steam distillation for 4 hours, collect the distillate, add an appropriate amount of sodium chloride to make it saturated, and collect the volatile oil to obtain the product;

[0049] The evening primrose seeds were pulverized, and subjected to supercritical CO at a temperature of 45 °C and a pressure of 32 MPa 2 Extraction, CO 2 The flow rate is 130kg / h, extract for 4h, collect, and get evening primrose oil;

[0050]Soak the gel base material carbomer and emulsifier polysorbate in water, place it for 30 hours, add a pH regulator to make the pH value 7.0, mix well, and make the gel matrix; wherein the am...

Embodiment 2

[0054] Prescription: evening primrose oil 50g, notopterygium extract 30g, vitamin E 12g, chitosan 10g, glycerin 55g, Tween 20 2g, absolute ethanol 45g, sodium hydroxide, hydrochloric acid, water;

[0055] Preparation:

[0056] Take the coarse powder of notopterygium medicinal materials, add 6 times the amount of water to soak for 60 minutes, extract the volatile oil of notopterygium by steam distillation for 6 hours, collect the distillate, add an appropriate amount of sodium chloride to make it saturated, collect the volatile oil, and obtain the product;

[0057] The evening primrose seeds were pulverized and subjected to supercritical CO at a temperature of 50 °C and a pressure of 30 MPa. 2 Extraction, CO 2 The flow rate is 120kg / h, extract for 5h, collect, and get evening primrose oil;

[0058] Soak gel-based chitosan and emulsifier Tween 20 in water, place for 15 hours, add pH regulator sodium hydroxide and hydrochloric acid to make the pH value 6.0, mix well, and make g...

Embodiment 3

[0062] Prescription: evening primrose oil 100g, notopterygium extract 25g, vitamin E 8g, polyvinyl alcohol 2g, sodium hyaluronate 3g, butylene glycol 45g, Tween 60 2.5g, absolute ethanol 35g, sodium citrate, glacial acetic acid ,water;

[0063] Preparation:

[0064] Take the coarse powder of notopterygium medicinal materials, add 10 times the amount of water to soak for 30 minutes, extract the volatile oil of notopterygium by steam distillation for 2.5 hours, collect the distillate, add an appropriate amount of sodium chloride to make it saturated, and collect the volatile oil to obtain the product;

[0065] The evening primrose seeds were pulverized and subjected to supercritical CO 2 Extraction, CO 2 The flow rate is 140kg / h, extract for 4.5h, collect, and get evening primrose oil;

[0066] Soak the gel base material polyvinyl alcohol, sodium hyaluronate and emulsifier Tween 60 in water, leave it for 48 hours, add pH regulator sodium citrate and glacial acetic acid to mak...

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PUM

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Abstract

The present invention discloses a gel preparation for curing subacute eczema and chronic eczema and its preparation method. Said preparation method includes the following steps: soaking gel base material and emulsifier in water, standing still for 15-48 h, adding pH regulating agent to make its pH value be 6.0-8.0, uniformly mixing them so as to obtain gel matrix; dissolving vitamin E in ethyl alcohol to obtain ethyl alcohol solution of vitamin E; successively adding the ethyl alcohol solution of vitamin E, humectants, evening primrose oil and notopterygium root extract into the above-mentioned gel matrix, uniformly stirring them, adding proper quantity of water, further uniformly stirring them so as to obtain the invented product.

Description

technical field [0001] The present invention relates to a gel preparation for treating subacute eczema and chronic eczema, in particular to a gel preparation for treating subacute eczema and chronic eczema, which has the functions of expelling wind, dehumidification, relieving itching, and detumescence. The preparation method and application of the gel preparation. Background technique [0002] Eczema is a common inflammatory skin disease. Its clinical features are polymorphic rash, which tends to ooze, is symmetrically distributed, and feels severe itching. The etiology is more complex, mostly due to the interaction of certain external or internal factors. Common external factors are chemical agents, cosmetics, spices, dyes, detergents, animal toxins, eggs, fish, shrimp, milk and other heterosexual proteins, pollen, Dust, bacterial infection, sun exposure, cold, scratching, etc. The common internal factors are allergic constitution, metabolic, endocrine or digestive tract ...

Claims

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Application Information

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IPC IPC(8): A61K36/237A61K9/00A61K47/36A61P17/00A61K31/355
Inventor 杨文龙
Owner 杨文龙
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