Beta-alkoxypropionamide compound, solvent, detergent, liquid pharmaceutical composition, and process for producing beta-alkoxypropionamide compound

A technology for alkoxypropionamides and medicines, applied in the fields of solvents, detergents and liquid pharmaceutical compositions, beta-alkoxypropionamides, and can solve the problems of rapid disappearance of effects, application limitations and the like

Active Publication Date: 2008-01-02
SHANDONG QINGYUN CHANGXIN CHEM SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of amide solvents is greatly limited due to their incompatibility with paraffins.
[0005] In addition, as solvents for agricultural preparations, conventional amide-based solvents have excellent solubility

Method used

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  • Beta-alkoxypropionamide compound, solvent, detergent, liquid pharmaceutical composition, and process for producing beta-alkoxypropionamide compound
  • Beta-alkoxypropionamide compound, solvent, detergent, liquid pharmaceutical composition, and process for producing beta-alkoxypropionamide compound
  • Beta-alkoxypropionamide compound, solvent, detergent, liquid pharmaceutical composition, and process for producing beta-alkoxypropionamide compound

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049]Another raw material in the preparation method of the present invention is an aliphatic monohydric alcohol with 5 to 18 carbon atoms, R in the above general formula (IV) 5 An alkyl group having 5 to 18 carbon atoms is formed. The aliphatic monohydric alcohol may be linear or branched, and specific examples thereof include n-pentanol, hexanol, octanol, 2-ethylhexanol, decyl alcohol, and lauryl alcohol.

[0050] When the β-alkoxypropionamides in the present invention are used in the form of a mixture as a solvent or a detergent, the mixture can be prepared during the reaction. At this time, the above-mentioned acrylamides as raw materials may be used in combination of at least two kinds; the above-mentioned aliphatic monohydric alcohols may be used in combination of at least two kinds; these two forms may also be used.

[0051] The use ratio of acrylamide and aliphatic monohydric alcohol is preferably stoichiometric or excessive, but it is generally disadvantageous in ter...

Embodiment 1

[0066] 19.828 g of N,N-dimethylacrylamide and 20.434 g of 1-hexanol were put into a 300 mL separable flask equipped with a stirring device, a thermocouple, and a nitrogen gas introduction tube, and stirred while introducing nitrogen gas. Then, 0.338 g of sodium tert-butoxide was added and reacted at 35° C. for 4 hours. After heating, 150 mg of phosphoric acid was added to make the solution uniform, and then left to stand for 3 hours. The solution was filtered to remove precipitates, and unreacted materials were further removed by an evaporator. The yield was 37.4 g (yield 93%).

[0067] determination of the resulting substance 1 As a result of H-NMR, 0.95 ppm (3H), 1.3-1.5 ppm (8H), 2.4 ppm (2H), 2.9 ppm (6H), 3.4 ppm (2H) and 3.7 ppm (2H) were observed. As a result, the following structure was found. A solubility test of the compound was performed. The results are shown in Table 1.

[0068] 【Compound 9】

[0069]

Embodiment 2

[0071] 19.828 g of N,N-dimethylacrylamide and 14.824 g of 1-butanol were put into a 300 mL separable flask equipped with a stirring device, a thermocouple, and a nitrogen gas introduction tube, and stirred while introducing nitrogen gas. Then, 0.338 g of sodium tert-butoxide was added and reacted at 35° C. for 4 hours. After heating, 150 mg of phosphoric acid was added to make the solution uniform, and then left to stand for 3 hours. The solution was filtered to remove precipitates, and unreacted materials were further removed by an evaporator. The yield was 30.5 g (yield 88%).

[0072] determination of the resulting substance 1 As a result of H-NMR, 0.95 ppm (3H), 1.3-1.5 ppm (4H), 2.4 ppm (2H), 2.9 ppm (6H), 3.4 ppm (2H) and 3.7 ppm (2H) were observed. As a result, the following structure was found. A solubility test of the compound was performed. The results are shown in Table 1.

[0073] 【Compound 10】

[0074]

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Abstract

The present invention discloses an Beta-alkoxypropionamide compound represented by the general formula (I); a solvent and a detergent each containing the alkoxypropionamide compound; a liquid chemical composition comprising a specific Beta-alkoxypropionamide compound and a chemical dissolved therein; and a process for producing a Beta-alkoxypropionamide compound which comprises reacting acrylamide with an aliphatic monohydric alcohol in the presence of a basic catalyst. The solvent and detergent each has excellent solubility which enables the solvent and detergent to dissolve also in paraffin, etc., while retaining the dissolving power of amide solvents. The liquid chemical composition contains any of various agricultural chemicals satisfactorily dissolved therein, and retains safety and long-lasting effectiveness. Also provided is a process for industrially advantageously producing the solvent and detergent.

Description

technical field [0001] The present invention relates to β-alkoxypropionamides, solvent, detergent, liquid medicine composition and preparation method of β-alkoxypropionamides. In more detail, it relates to solvents, detergents and liquid pharmaceutical compositions containing novel β-alkoxypropionamides and the efficient preparation of the β-alkoxypropionamides by reacting acrylamides with aliphatic monohydric alcohols under mild conditions. The method of alkoxypropionamides. Background technique [0002] In general, amides organic solvents can be rinsed with water due to their excellent solvency and water-soluble properties, and have preferred properties as solvents or detergents. In addition, recently, since halogenated solvents may cause environmental pollution such as ozone depletion or are highly toxic, amide-based solvents tend to replace the previous halogenated solvents. [0003] As the amide solvent, for example, formamide, N-monomethylformamide, N,N-dimethylforma...

Claims

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Application Information

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IPC IPC(8): C07C235/06A01N25/02C07C231/12C11D1/52
CPCC07C235/06C11D1/52C07C231/12C07C233/02C07C233/05C11D11/0094
Inventor 松尾茂
Owner SHANDONG QINGYUN CHANGXIN CHEM SCI TECH
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