Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Azelnidipine medicinal composition and its preparing method

A technology of azelnidipine and its composition, which is applied in the field of pharmaceutical compositions containing azelnidipine, and can solve problems such as the decrease of dissolution rate

Inactive Publication Date: 2010-12-08
BEIJING SIHUAN KEBAO PHARM CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This research tries to adopt the method mentioned in this patent to prepare the azelnidipine pharmaceutical composition, and finds that after the obtained composition is further prepared into tablets, capsules or dispersible tablets, although it shows better storage stability, but with With the prolongation of storage time, various dosage forms show a trend of decreasing dissolution rate
Although the dissolution decline trend is still within the qualified range, it still leaves hidden dangers for industrialized large-scale production and subsequent marketing of drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Azelnidipine medicinal composition and its preparing method
  • Azelnidipine medicinal composition and its preparing method
  • Azelnidipine medicinal composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation Process:

[0033] 1. Azhedipine and calcium hydrogen phosphate pass through a 120-mesh sieve; talcum powder and magnesium stearate pass through a 60-mesh sieve; other auxiliary materials pass through a 80-mesh sieve for later use;

[0034] 2. After weighing the prescribed amount of Azendipine and lactose and mixing evenly, dissolve the prescribed amount of Tween 80 in a small amount of water (concentration is about 23%) and add it to mix evenly, then mix with calcium hydrogen phosphate, low-substituted hydroxypropyl fiber Sodium acetate and sodium acetate are mixed homogeneously according to the principle of increasing in equal amounts, to obtain mixture I;

[0035] 3. Mixture I uses water as a wetting agent to make a soft material, and passes through a 18-mesh sieve to granulate. Wet granules are blast-dried in an oven at 50°C, and sieved with a 24-mesh sieve after completion;

[0036] 4. Add talcum powder and magnesium stearate in the prescri...

Embodiment 2

[0039]

[0040] Preparation Process:

[0041] 1. Azhedipine and calcium hydrogen phosphate are passed through a 120-mesh sieve; magnesium stearate is passed through a 60-mesh sieve; other auxiliary materials are passed through a 80-mesh sieve for later use;

[0042] 2. Weigh the prescribed amount of Azendipine and mix it with lactose evenly, dissolve the prescribed amount of Tween 80 in a small amount of water (concentration is about 23%) and add it to mix evenly, then mix with calcium hydrogen phosphate, low-substituted hydroxypropyl cellulose Mix uniformly with sodium acetate according to the principle of equal addition, to obtain mixture I;

[0043] 3. Mixture I uses water as a wetting agent to make a soft material, and passes through a 18-mesh sieve to granulate. Wet granules are blast-dried in an oven at 50°C, and sieved with a 24-mesh sieve after completion;

[0044] 4. Add the prescribed proportion of magnesium stearate to the dried granules, and mix well;

[0045...

Embodiment 3

[0047]

[0048] Preparation Process:

[0049] 1. Azhedipine is passed through a 120-mesh sieve; magnesium stearate is passed through a 60-mesh sieve; other excipients are passed through a 80-mesh sieve for later use;

[0050] 2. Weigh the prescribed amount of Azendipine and mix it evenly with lactose, dissolve the prescribed amount of Tween 80 in a small amount of water (concentration is about 23%) and add it to mix evenly, then mix it with microcrystalline cellulose, some low-substituted hydroxypropyl Cellulose and sodium acetate are mixed homogeneously according to the principle of increasing in equal amounts to obtain mixture I;

[0051] 3. Mixture I uses water as a wetting agent to make a soft material, and passes through a 18-mesh sieve to granulate. Wet granules are blast-dried in an oven at 50°C, and sieved with a 24-mesh sieve after completion;

[0052] 4. Add the prescribed proportion to the dried granules, plus some low-substituted hydroxypropyl cellulose and ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a compound for treating hypertensive, particularly relating to a calcium ion antagonist drug complex with full dissolution, good stability and high bioavailability. The invention is characterized in that the complex contains (A) calcium channel antagonist, (B) alkaline excipient with effective dose and (C) non-ionic surfactant; wherein (A):(B):(C) is ranged from 0.1:1:1 to 10:1:1.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing azendipine, which can be used in the treatment of hypertension. In particular, the present invention relates to an azeldipine pharmaceutical composition with complete dissolution, good stability and high bioavailability. Background technique [0002] At present, hypertension has become the main killer that endangers human health, and patients with hypertension account for about 50% of cardiovascular cases. According to statistics from the National Ministry of Health, there are 130 million hypertensive patients in my country, and the incidence rate increases by 25% every 10 years, with an annual increase of more than 3 million people. Azedipine is a new generation of L-type calcium channel selective antagonist. This product has clinical advantages such as good antihypertensive effect, does not affect heart rate, can improve renal function, and has few side effects. Therefore, pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4427A61K47/34A61P9/12A61K47/26
Inventor 廖娟
Owner BEIJING SIHUAN KEBAO PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com