Dexamethasone sodium phosphate injection

Abstract

Dexamethasone sodium phosphate injection comprises the medicinal propanediol with the volume ratio of 4 percent to 6 percent, the phosphate buffer of 0.3 percent to 0.5 percent with the PH value of 8.0, the dexamethasone sodium phosphate and the injection water. Content of the dexamethasone sodium phosphate is 2mg to 5 mg per ml. The application is safe and the cost is low in the present invention.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, in particular to a dexamethasone sodium phosphate injection. Background technique [0002] Dexamethasone sodium phosphate, chemical name 16α-methyl-11β,17α,21-trihydroxy-9α-flupregna-1,4-diene-3,20-dione-21-phosphate disodium salt , is an adrenal cortex hormone drug with anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects. The mechanism of action is: (1) Anti-inflammatory effect: it can reduce and prevent the response of tissues to inflammation, thereby reducing the manifestation of inflammation. It can inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. (2) Immunosuppressive effects: including preventing or inhibiting cell-mediated immune responses, delayed allergic r...

AI Technical Summary

Problems solved by technology

[0010] In the production process of dexamethasone sodium phosphate injection, the concentration generally adopted by manufacturers is about 30% (volume ratio; that is, 3000ml of medicinal propylene glycol needs to be added for every 10,000ml of dexamethasone sodium phosphate liquid medicine prep...