Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Device and method for photodynamic therapy of the nasopharyngeal cavity

A technology of photodynamic therapy and nasopharynx, which is applied in phototherapy, therapy, radiotherapy, etc., and can solve problems such as tumor recurrence

Inactive Publication Date: 2008-02-20
ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, uniform radiation is critical to prevent underexposure of diseased areas, which would lead to tumor recurrence

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Device and method for photodynamic therapy of the nasopharyngeal cavity
  • Device and method for photodynamic therapy of the nasopharyngeal cavity
  • Device and method for photodynamic therapy of the nasopharyngeal cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] The present invention generally provides devices and methods for delivering light to the nasopharyngeal cavity in a controlled and reproducible manner. Furthermore, the present invention provides positioning means for stable and reproducible positioning of optical fibers in irregularly shaped chambers for delivery of uniform illumination. In a preferred embodiment, the inventive localization device provides improved PDT treatment for diseases in the nasopharynx. Finally, the present invention provides systems and methods for delivering uniform illumination and controlling the manner and characteristics of illumination during PDT.

[0030] FIG. 1A depicts the basic shape of positioning device 100 for guiding multiple optical fibers (see FIG. 3 ) and control components (see FIG. 4 ) into nasopharyngeal cavity 502 (see FIG. 5 ).

[0031]In this embodiment, the positioning device 100 consists of at least one hollow guide tube 102 or preferably two hollow guide tubes 102 an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A device / system and method for the delivery of light to the nasopharyngeal cavity in a controlled and reproducible mariner using at least one optical fiber having a linear diffusing tip, a spherical diffusing tip, or a bare cut end is disclosed. A positioning device may have one or two flexible guide tubes that are attached to a preformed shaped base that is introduced into the nasopharyngeal cavity to guide and position the optical fibers and / or detector(s). The optical fibers are enclosed within shielding tubes which are inserted into the guide tubes. The optical fibers may be further moved within the shielding tube so as to adjust the amount of output light. Also included within the guide tube is a light detector that monitors, detects, and measures the delivery of fluence rates to pre-determined locations in the nasopharyngeal cavity. The detector may also be enclosed within a separate tube within the guide tube. The inventive device / system also has a means of shielding pre-selected areas of the nasopharyngeal cavity or adjacent tissues from the light delivered by the optical fibers. The system of the present invention uses a control unit and preselected treatment parameters to monitor, regulate, and display laser output and fluence rates at preselected locations in the nasopharyngeal cavity during PDT treatment.

Description

[0001] Priority under 35 USC 119(e) [0002] This application claims the benefit of US Provisional Application Serial No. 60 / 629,765, filed November 20, 2004, which is incorporated herein by reference. technical field [0003] The present invention relates to the field of photodynamic therapy, and more particularly, to devices and methods for the controlled delivery of light to the nasopharyngeal cavity for the treatment of cancer. Background technique [0004] Photodynamic therapy (PDT) is a minimally invasive, non-surgical treatment option for a variety of diseases, including cancer. PDT uses photosensitizing drugs and specific wavelengths of visible light to generate pure oxygen, which in turn causes oxidative damage in target tissues. The cumulative effects of oxidative damage, ie necrosis, apoptosis and / or vessel collapse, lead to localized destruction of the target tissue. PDT treatment results in localized and specific tissue destruction in part because visible ligh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61N5/06
CPCA61N5/062A61N5/0601A61N2005/0607A61N5/0603
Inventor H·J·C·M·斯泰岚柏格陈英明彼得·C·莱文达
Owner ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com