Device and method for photodynamic therapy of the nasopharyngeal cavity

A technology of photodynamic therapy and nasopharynx, which is applied in phototherapy, therapy, radiotherapy, etc., and can solve problems such as tumor recurrence

Inactive Publication Date: 2008-02-20
ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, uniform radiation is critical to prevent underexposure of diseased areas, which would lead to tumor recurrence

Method used

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  • Device and method for photodynamic therapy of the nasopharyngeal cavity
  • Device and method for photodynamic therapy of the nasopharyngeal cavity
  • Device and method for photodynamic therapy of the nasopharyngeal cavity

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Embodiment Construction

[0029] The present invention generally provides devices and methods for delivering light to the nasopharyngeal cavity in a controlled and reproducible manner. Furthermore, the present invention provides positioning means for stable and reproducible positioning of optical fibers in irregularly shaped chambers for delivery of uniform illumination. In a preferred embodiment, the inventive localization device provides improved PDT treatment for diseases in the nasopharynx. Finally, the present invention provides systems and methods for delivering uniform illumination and controlling the manner and characteristics of illumination during PDT.

[0030] FIG. 1A depicts the basic shape of positioning device 100 for guiding multiple optical fibers (see FIG. 3 ) and control components (see FIG. 4 ) into nasopharyngeal cavity 502 (see FIG. 5 ).

[0031]In this embodiment, the positioning device 100 consists of at least one hollow guide tube 102 or preferably two hollow guide tubes 102 an...

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Abstract

A device / system and method for the delivery of light to the nasopharyngeal cavity in a controlled and reproducible mariner using at least one optical fiber having a linear diffusing tip, a spherical diffusing tip, or a bare cut end is disclosed. A positioning device may have one or two flexible guide tubes that are attached to a preformed shaped base that is introduced into the nasopharyngeal cavity to guide and position the optical fibers and / or detector(s). The optical fibers are enclosed within shielding tubes which are inserted into the guide tubes. The optical fibers may be further moved within the shielding tube so as to adjust the amount of output light. Also included within the guide tube is a light detector that monitors, detects, and measures the delivery of fluence rates to pre-determined locations in the nasopharyngeal cavity. The detector may also be enclosed within a separate tube within the guide tube. The inventive device / system also has a means of shielding pre-selected areas of the nasopharyngeal cavity or adjacent tissues from the light delivered by the optical fibers. The system of the present invention uses a control unit and preselected treatment parameters to monitor, regulate, and display laser output and fluence rates at preselected locations in the nasopharyngeal cavity during PDT treatment.

Description

[0001] Priority under 35 USC 119(e) [0002] This application claims the benefit of US Provisional Application Serial No. 60 / 629,765, filed November 20, 2004, which is incorporated herein by reference. technical field [0003] The present invention relates to the field of photodynamic therapy, and more particularly, to devices and methods for the controlled delivery of light to the nasopharyngeal cavity for the treatment of cancer. Background technique [0004] Photodynamic therapy (PDT) is a minimally invasive, non-surgical treatment option for a variety of diseases, including cancer. PDT uses photosensitizing drugs and specific wavelengths of visible light to generate pure oxygen, which in turn causes oxidative damage in target tissues. The cumulative effects of oxidative damage, ie necrosis, apoptosis and / or vessel collapse, lead to localized destruction of the target tissue. PDT treatment results in localized and specific tissue destruction in part because visible ligh...

Claims

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Application Information

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IPC IPC(8): A61N5/06
CPCA61N5/062A61N5/0601A61N2005/0607A61N5/0603
Inventor H·J·C·M·斯泰岚柏格陈英明彼得·C·莱文达
Owner ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
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