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Nimodipine pharmaceutical composition and method of producing the same

A technology of nimodipine and its composition, which is applied in the field of nimodipine injection or oral pharmaceutical preparations and its preparation, can solve problems such as complicated preparation methods, and achieve the effects of high system stability, stable content, and safe and reliable use

Inactive Publication Date: 2008-02-27
沈阳万爱普利德医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is necessary to develop new dosage forms. Although there are patents on the preparation method of nimodipine for injection, there are still deficiencies due to the cumbersome preparation methods or the domestic pharmaceutical grade standards for some additives that need to be added.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] Nimodipine 4mg

[0028] Tween 80 0.40g

[0029] Poloxamer 188 0.55g

[0030] Ethanol 0.4ml

[0031] Water for injection to 1ml

[0032] Preparation method: add nimodipine to ethanol, dissolve Tween 80 and poloxamer 188 in a certain amount of water, mix the two solutions, add water for injection to the specified volume, add activated carbon and absorb at 60°C for 20 minutes, Sterilize by recirculating steam, pack and get ready.

example 2

[0034] Nimodipine 4mg

[0035] Tween 80 0.40g

[0036] Poloxamer 407 0.60g

[0037] Ethanol 0.4ml

[0038] Water for injection to 1ml

[0039] Preparation method: add nimodipine to ethanol, dissolve Tween 80 and poloxamer 407 in a certain amount of water, mix the two solutions, add water for injection to the specified volume, add activated carbon and absorb at 60°C for 30 minutes, Re-autoclave, pack and get ready.

example 3

[0041] Nimodipine 2mg

[0042] Propylene glycol 0.084

[0043] Tween-80 0.166

[0044] 50% alcohol to 2ml

[0045] Preparation method: Add nimodipine to ethanol, dissolve Tween 80 and propylene glycol in a certain amount of water, mix the two solutions, add water for injection to the specified volume, add activated carbon to absorb at 60°C for 60 minutes, and then circulate steam Sterilize for 20 minutes, pack and get ready.

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PUM

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Abstract

The invention discloses a new nimodiping drug composition and making method, which is made of nimodiping, sorbitol or dehydration sorbitol fatty acid simple lipid surface activator, benign solvent of nimodiping, auxiliary solubilizer and injecting water to form the concentrated solution of injection or oral agent. The invention has big density, good stability, low findings and simple making technique, which can't induce damage for brain tissue due to cerebrovascular spasm.

Description

technical field [0001] The invention relates to a nimodipine injection or oral pharmaceutical preparation and a preparation method thereof. technical background [0002] Nimodipine is a second-generation l,4-dihydropyridine calcium channel blocker with the molecular formula C 21 h 26 N 2 o 7 , the molecular weight is 418.45. It has anti-vasoconstriction and anti-ischemic effects on the brain. Nimodipine can prevent or eliminate various vasoactive substances (such as 5-hydroxytryptamine, prostaglandin and histamine) or blood and its degradation products. Modipine also has neurological and psychopharmacological properties. Studies on patients with acute cerebral blood supply disorders have shown that nimodipine can expand cerebral blood vessels and improve cerebral blood supply, and the increase in perfusion to brain damage and insufficient perfusion is usually greater than normal parts. Ischemic potassium damage and mortality. [0003] Nimodipine is a dihydropyridine c...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K47/34A61P9/10A61K47/10A61K47/26
Inventor 李淑斌洪伟宁红刘丹黄海
Owner 沈阳万爱普利德医药科技有限公司
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