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Composition for treating knee-joint cross ligament damage

An anterior cruciate ligament and composition technology, which is applied in the field of therapeutic pharmaceutical compositions for knee anterior cruciate ligament injury, can solve problems such as no cure for anterior cruciate ligament, and achieve the effect of significant curative effect and inhibition of excessive release

Inactive Publication Date: 2008-03-26
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching, 170 documents related to "anterior cruciate ligament" were analyzed, and more than 95% of the technologies were related to the reconstruction of the anterior cruciate ligament, including reconstruction instruments and alternatives, and the patents intersecting with matrix metalloproteinases were 0, and there is no report on any patent application and authorization and related literature to achieve healing of the anterior cruciate ligament by inhibiting matrix metalloproteinases

Method used

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  • Composition for treating knee-joint cross ligament damage
  • Composition for treating knee-joint cross ligament damage
  • Composition for treating knee-joint cross ligament damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Composition formula 1

[0027] Composition ingredients: retinoic acid 50ng / ml, tetracycline 10 -4 M, curcumin 50μM, transforming growth factor 10ng / ml.

[0028] Preparation method:

[0029] Dilute with 2.5 mL of chilled PBS, adjust the pH to 7.4 with 0.2 M NaOH, and maintain at 250-300 milliosmolar (mOsm). The composition was added to the pH-adjusted solution to achieve a final total concentration of 2 mg / mL.

[0030] Experimental animals: Wistar rats weighing 220±20 g, male, in three groups, 10 in each group.

[0031] The two groups of rats underwent ACL rupture surgery, and then they were reunited.

[0032] After one group was reunited, in order to alleviate the postoperative pain of the rats, in the first 5 days, 0.01-0.05mg / ml of analgesics was injected every 12 hours to allow them to recover automatically.

[0033] In the other group, 3 μL of sterilized collagen gel was applied to the ACL-ACL suture after the surgery. After 50 minutes, 5 μL of the...

Embodiment 2

[0037] Embodiment 2: Composition formula 2

[0038] Ingredients: Tretinoin 50ng / ml, Tetracycline 10 -4 M, curcumin 50μM, transforming growth factor 30ng / ml.

[0039] Preparation method: with embodiment 1

[0040] Experimental animals: Wistar rats weighing 220±20 g, male, in three groups.

[0041] Test process: with embodiment 1

[0042] 6 weeks later. All the rats were sacrificed, and the bone-ligament-bone complex was taken out, see Fig. 3, and the tensile strength of the ligament was measured. Result table two:

[0043] Table II

[0044] group

Embodiment 3

[0045] Embodiment 3: Composition formula 3

[0046] Composition ingredients: retinoic acid 50ng / ml, tetracycline 10 -4 M, NF-κB inhibitor 50μM, transforming growth factor 30ng / ml.

[0047] Preparation method: with embodiment 1

[0048] Experimental animals: Wistar rats weighing 220±20 g, male, in three groups.

[0049] Test process: with embodiment 1

[0050] 6 weeks later. All the rats were sacrificed, and the bone-ligament-bone complex was taken out, see Fig. 4, and the tensile strength of the ligament was measured. Result table three:

[0051] Table three

[0052] group

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PUM

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Abstract

The present invention relates to a medicine composition for effectively curing injury of anterior cruciate ligament of knee joint. Said medicine composition contains trans forming growth factor, matrix metal proteinase inhibitor and inflammation bloker, and the optimum components of said medicine composition are transforming growth factor + vitamin A acid + tetracycline + NF -k B inhibitor.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating soft tissue injury, in particular to a pharmaceutical composition for treating anterior cruciate ligament injury of the knee joint. The composition contains growth factors, matrix metalloproteinase inhibitors, and anti-inflammatory factors. technical background [0002] Due to frequent injuries of the anterior cruciate ligament and medial collateral ligament during sports, it has a great impact on joint function. In the past 30 years, researchers and doctors have done a lot of research work on the repair of knee ligaments. By the end of the last century, the most important clinical phenomenon that has been widely observed is that the anterior cruciate ligament and the medial collateral ligament have different healing ability; after the ligament is damaged by force, the medial collateral ligament, which is also composed of most fibroblasts and fibers, has a functional self-healing respon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/55A61K38/18A61K38/30A61P19/02A61P19/04A61K31/19A61K31/122A61K31/65
Inventor 宋国立杨力蒋稼欢杨荣李苑
Owner CHONGQING UNIV
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