Useful high load concentrate compositions for control of ecto-and endo-parasites

A composition and compound technology, which is applied in the direction of chemicals, drug combinations, biocides, etc. for biological control, and can solve the problems of insolubility, instability and difficulty in deployment of metaflumimid

Inactive Publication Date: 2008-05-14
WYETH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is particularly advantageous as it provides 4-6 weeks of protection from fleas and ticks in companion animals, but it will potentially be useful in many other species if appropriate formulations can be developed
However, the insolubility of metaflumizone in many solvents and its instability in the presence of primary alcohols make it difficult to formulate

Method used

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  • Useful high load concentrate compositions for control of ecto-and endo-parasites

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0045] Preparation of Metaflumizone / Mastatin High Load Concentrate Suitable for Use as Spray Drops

[0046] 100 g weight of dimethyl sulfoxide (DMSO) was added to 400 g gamma-caprolactone. 200 g of metaflumizone was added to this solvent system. Metaflumizone was dissolved in the solvent system. Weigh 10 g of Mastatine and add it to the current solution containing Metaflumizone. Dissolve the Mastatin. To the resulting solution was added 60 g of an alcohol alkoxylate surfactant (sold under the tradename Synperonic(R) NCA) and the surfactant was allowed to dissolve. Finally, the volume of the solution was brought to 1000 ml with γ-caprolactone.

example 2

[0048] Preparation of Metaflumizone / Mastatin Pour-on from High Load Concentrate (Example 1)

[0049] Gamma-caprolactone in sufficient quantity to 100 ml was added to 25 ml of the high load concentrate prepared in Example 1. This provides a pour with sufficient metaflumizone and mostatin and volume to treat 5 cattle weighing 200 Kg each at a dose rate of 5 mg / kg metaflumizone and a dose rate of 0.25 mg / kg mostatin formulations.

example 3

[0051] Preparation of high-capacity concentrates for use as concentrates for the preparation of metaflumizone sprays or feed / water supplements

[0052] 12.59 g of metaflumizone were added to the methoxypropyl acetate using mild heating (approximately 40°C). While stirring, to this solution was added 109.92 g of polyethoxylated castor oil (sold under the tradename Cremophor(R) EL), followed by 1.0 g of Mastatin, and then brought to volume with methoxypropyl acetate. .

[0053] The resulting solution is stored until ready to use, after which it can be diluted with water for use as a spray (dilute 17ml concentrate to 3500ml with water) or water for use as a feed / water additive (at approximately the same ratio) or otherwise directly as a topline Applied in pour-on form.

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Abstract

The invention prepares high load concentrate compositions comprising metaflumizone, a substantially water-insoluble anti-parasitic macrolide compound,such as moxidectin, an optional bridging agent, a surfactant, and a suitable carrier solvent are prepared. These compositions may be topically administered to animals, and are useful for preventing or treating ectoparasitic infestations in warm-blooded animals for prolonged periods of time. Additionally, they may be further diluted to provide other types of formulations useable for both topical and oral administration.

Description

technical field [0001] none Background technique [0002] Arthropod ectoparasites that commonly infect warm-blooded animals include ticks, mites, white lice, fleas, blowflies, the ectoparasite Lucilia sp. of sheep, including the sheep tick (Melophagus ovinus )) biting insects and migratory dipteran larvae (such as Hypoderma sp. and Dermatobia on cattle, Gastrophilus on horses and yellow flies on rodents ( Cuterebra sp.)). [0003] Helminthiasis is an endemic disease found in many animals and causes significant economic losses throughout the world. Among worms, groups of worms called nematodes are most commonly encountered. Nematodes are found in the gastrointestinal tract, heart, lungs, blood vessels and other body tissues of animals and are a major cause of anemia, weight loss and malnutrition in infected animals. It severely damages the walls and tissues of the organs in which it colonizes and, if left untreated, can cause death in infected animals. [0004] Pathogen-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01P5/00A01P7/02A01P7/04A01N43/90A01N47/34
CPCA01N43/90A01N47/34A61P33/00A61P33/10A61P33/14A01N25/30A01N25/02A01N2300/00
Inventor 罗伯特·B·奥尔布赖特
Owner WYETH LLC
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