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Depression treating medicine and preparation method thereof

A technology for depression and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as toxicity, side effects, addiction, and high prices

Inactive Publication Date: 2008-05-21
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing antidepressant drugs are mainly western medicines, which are not only expensive, but also have relatively large toxic and side effects or addiction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] [embodiment 1] capsule preparation of medicine of the present invention

[0126] A capsule for treating depression, its preparation method is as follows:

[0127] (1) Proportioning by weight of each raw material drug in Table 12: first mix Acorus calamus and Patchouli wherein, adopt steam distillation method to extract volatile oil for 5 hours, after collecting volatile oil for subsequent use, remaining decocted medicinal liquid is filtered Obtain filtrate A for subsequent use;

[0128] (2) Mix the dregs obtained after filtering the above-mentioned decocted medicinal liquid with the rest of the raw materials in the above weight ratio, add water to decoct and extract 4 times, wherein the first and second decoctions add 12 times the amount of water, and the third 1. Add 8 times the amount of water for 4 decoctions, decoct for 40 minutes each time, combine the 4 decoctions, and filter to obtain filtrate B;

[0129] (3) Combine the above filtrate A and filtrate B and pass...

Embodiment 2

[0131] [embodiment 2] capsule preparation of medicine of the present invention

[0132] The difference from [Example 1] in its preparation steps is that: the weight ratio of each raw material medicine is as shown in Table 12; the time for decocting with water and distilling and extracting the volatile oil is 4 hours; 101 After being adsorbed by a type macroporous resin, it is eluted with ethanol with a concentration of 85%. After collecting the volatile oil, the volatile oil is wrapped into a β-cyclodextrin inclusion compound of the volatile oil and then packed into a capsule to make a capsule.

[0133] Wherein the wrapping step of volatile oil is: first add volatile oil to an appropriate amount of absolute ethanol, mix to make 50% ethanol solution of volatile oil, then according to the ratio of volatile oil: β-cyclodextrin: water=1:5:50, put The β-cyclodextrin and water are mixed, heated and dissolved, then cooled to 75-55°C, and placed on a constant temperature magnetic stir...

Embodiment 3

[0135] [embodiment 3] capsule preparation of medicine of the present invention

[0136] The difference from [Example 1] in its preparation steps is that: the weight ratio of each raw drug is as shown in Table 12; the time for decocting with water and distilling and extracting the volatile oil is 6 hours; 101 After being adsorbed by a type macroporous resin, elute with 75% ethanol; concentrate the ethanol eluate into an extract with a relative density of 1.0 to 2.20 at T=60°C, add an appropriate amount of silicon dioxide, mix and pulverize, Pass through a 60-mesh sieve, and dry at a temperature of 65-70°C so that the moisture after drying is within 10%, then add β-cyclodextrin inclusion compound of volatile oil and mix, pack into capsules to prepare the drug of the present invention capsules.

[0137] All the other steps are the same as [Example 1].

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PUM

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Abstract

The invention provides a medicine for treating depression, which is characterized in that it is prepared from the following raw materials by weight: 625-1680 parts of Suanzaoren, 580-1720 parts of American ginseng, 385-970 parts of Anemarrhena, and 440 parts of Fushen ~ 1100 copies, 520-1280 copies of Rehmannia glutinosa, 470-1310 copies of Shichangpu, 300-900 copies of Polygala and 350-1050 copies of Patchouli. The invention provides a Chinese patent medicine with small dosage, high content of active ingredients, reliable curative effect for treating depression, small side effects and low cost for clinical use.

Description

technical field [0001] The invention relates to a medicine for treating depression and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Depression is a mental disorder characterized by persistent low emotion, often accompanied by slow thinking, slow behavior, and various somatic symptoms. During a depressive episode, the patient feels deep pain and is difficult to understand, which increases the degree of pain. The social functions of the patients are severely impaired, the quality of life is significantly reduced, and even suicidal behavior occurs. The suicide rate of depression is as high as 10% to 17%. Serious consequences for society and families. Existing antidepressants are mainly western medicines, which are not only expensive, but also have relatively large toxic and side effects or addiction. Contents of the invention [0003] The object of the present invention is to provide a Chinese patent m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K47/40A61P25/24
Inventor 蒋渝张莉秦剑王天文李青钟代华肖铭玉
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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