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Medicine preparation for treating traumatic injuries and its preparation method and quality control method

A technology of pharmaceutical preparations and traditional Chinese medicine preparations, which is applied in the field of traditional Chinese medicine preparations and new liquid pharmaceutical preparations, and can solve problems such as increased surface energy, increased adsorption, and particle instability

Inactive Publication Date: 2008-05-28
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the influence of the traditional pulverization concept, the current ultrafine pulverization technology is only reflected in the change of pulverization equipment, and has not brought a revolutionary impact to the traditional Chinese medicine preparation industry. The main problems are as follows: ① During the pulverization process of medicinal materials , as the particle size decreases, the energy required for further crushing continues to increase. When the particle size reaches a certain level, the crushing efficiency decreases significantly; ②Even after the crushing is completed, it is still easy to Lead to: increase in surface energy, making the particles in an unstable state; poor fluidity, easy to aggregate to form false large particles; increased wettability, easy to absorb moisture; increased adsorption, easy to absorb impurities in the air; ③ Due to the existence of the above problems, lead to In the preparation process of traditional Chinese medicine micropowder, there are technical problems such as poor powder fluidity, inaccurate dosage, easy moisture absorption, and difficult tablet molding, which seriously affect the practical application of traditional Chinese medicine micropowder. Bottlenecks in linking formulations

Method used

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  • Medicine preparation for treating traumatic injuries and its preparation method and quality control method
  • Medicine preparation for treating traumatic injuries and its preparation method and quality control method
  • Medicine preparation for treating traumatic injuries and its preparation method and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0282] [Prescription] Dried Blood 12kg Frankincense (made) 1.5kg Myrrh (made) 1.5kg

[0283] Safflower 1.5kg Catechin 2.6kg Borneol 0.15kg

[0284] Artificial Musk 0.15kg Cinnabar 1.2kg

[0285] [Preparation method] The above eight flavors, except artificial musk and borneol, are cinnabar water fly to very fine powder, and set aside; the remaining five flavors are crushed into coarse powder, passed through a No. 2 sieve, mixed with the above artificial musk and borneol, and the obtained powder is mixed with cinnabar water fly powder 60 Co-γ-ray radiation sterilization (4 ~ 6kGy). Take 20.6kg of the above-mentioned medicinal powder and substrate (polyethylene glycol 18.54kg and propylene glycol 2.06g, mix uniformly) and pulverize and mix in a vibrating ultrafine pulverizer for 20 minutes, add cinnabar powder, continue pulverizing and mixing for 10 minutes, and discharge , made into 100,000 soft capsules.

Embodiment 2

[0287] [Prescription] Dried Blood 15kg Frankincense (made) 2.5kg Myrrh (made) 2.5kg

[0288] Safflower 2.5kg Catechin 3.6kg Borneol 0.2kg

[0289] Artificial Musk 0.2kg Cinnabar 2kg

[0290] [Preparation method] The above eight flavors, except artificial musk and borneol, are cinnabar water fly to very fine powder, and set aside; the remaining five flavors are crushed into coarse powder, passed through a No. 2 sieve, mixed with the above artificial musk and borneol, and the obtained powder is mixed with cinnabar water fly powder 60 Co-γ-ray radiation sterilization (4 ~ 6kGy). Get above-mentioned medicated powder and matrix 85.5kg (polyethylene glycol 57kg and propylene glycol 28.5kg, mix homogeneously) after pulverizing and mixing in the vibrating type ultrafine grinder for 40 minutes, add cinnabar powder, continue pulverizing and mixing for 10 minutes, discharging, Make 100,000 liquid hard capsules to get final product.

Embodiment 3

[0292] [Prescription] Dried Blood 1363.1g, Frankincense (made) 204.5g, Myrrh (made) 204.5g

[0293] Safflower 204.5g Catechin 327.2g Borneol 16.4g

[0294] Artificial Musk 16.4g Cinnabar 163.6g

[0295] [Preparation method] The above eight flavors, except artificial musk and borneol, are cinnabar water fly to very fine powder, and set aside; the remaining five flavors are crushed into coarse powder, passed through a No. 2 sieve, mixed with the above artificial musk and borneol, and the obtained powder is mixed with cinnabar water fly powder 60 Co-γ-ray radiation sterilization (4 ~ 6kGy). Take the above medicated powder and 3500g of base (polyethylene glycol 3150g and propylene glycol 350g, mix uniformly) and pulverize and mix in a vibrating ultrafine pulverizer for 50 minutes, add cinnabar powder, continue pulverizing and mixing for 10 minutes, and discharge to obtain 10,000 soft capsules, ready to use.

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Abstract

The invention discloses a traditional Chinese medicine preparation, in particular to a novel liquid pharmaceutical preparation for the treatment of traumatic injuries, blood stasis and pains, which pertains to the filed of traditional Chinese medicine. The preparation is prepared by the following method: the dragon's blood, prepared frankincense, prepared myrrh, borneol, catechu, safflower, artificial musk, cinnabar and other medicines are taken, appropriate times of liquid dispersion media is added after conventional smashing, the mixture is smashed and mixed in an ultra-micro pulverizer, and the preparation is prepared by the smashed things. The application of the method can effectively improve the smashing efficiency of the raw materials, save the medicines and facilitate preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a new liquid medicinal preparation for treating bruises, which belongs to the field of traditional Chinese medicines. Background technique [0002] Fracture is a common clinical disease and frequently-occurring disease in orthopedics and traumatology. With the development of social economy and civilization, motor vehicles have gradually replaced traditional non-powered vehicles. With the increase in the incidence of traffic accidents, the incidence of fractures is also increasing . Modern medical treatment of fractures is mainly based on surgical treatment, and postoperative treatments such as anti-infection and pain relief are mainly used, and there is a lack of therapeutic methods to promote fractures. Traditional Chinese medicine has a long history of treating fractures, and there are various methods. In addition to manipulative restoration and splint fixation, tr...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K9/48A61K47/10A61K47/34A61K47/44G01N30/02G01N30/90A61P19/08A61P29/00A61K31/045A61K33/28A61K35/55A61K47/26
Inventor 张佳余刘国飞
Owner 北京凯瑞创新医药科技有限公司