Novel method for fine purification of theobromine

A technology of theobromine and a new method, which is applied in the field of theobromine refining, can solve the problems of high cost, low refining rate, loss of theobromine, etc., and achieve the effect of low cost and good product quality

Inactive Publication Date: 2008-06-11
PERRIGO TRADING (SHANGHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Refined twice, low refining rate
In addition, because sulfuric acid is destructive to a certain extent, a part of theobromine is lost, and the cost is high, which has an adverse effect on production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] In a 250ml four-necked reaction flask with stirring, add 20g of crude theobromine, 120ml of water, and 12ml of 30% liquid caustic soda, heat up to 70-80°C while stirring, and add 1g of activated carbon. Decolorize at this temperature for half an hour. Filtrate, add 0.2 g of sodium metabisulfite to the filtrate, stir and cool down to 70°C, keep at 65-70°C, acidify with concentrated hydrochloric acid to pH: 5-6, cool down to 25°C, filter, wash with deionized water until the chloride ion is qualified, Dried to obtain 18.5 grams of theobromine finished product. According to cp2005, EP4, USP27 full inspection passed.

Embodiment 2

[0014] In a 250ml four-necked reaction flask with stirring, add 20g of crude theobromine, 120ml of water, and 12ml of 30% liquid caustic soda, heat up to 70-80°C while stirring, and add 1g of activated carbon. Decolorize at this temperature for half an hour. Filtrate, add 0.3 g of sodium bisulfite to the filtrate, stir and cool down to 70°C, keep at 65-70°C, acidify with concentrated hydrochloric acid to pH: 5-6, cool down to 25°C, filter, wash with deionized water until chloride ions Qualified, and dried to obtain 18.6 grams of theobromine finished product. According to cp2005, EP4, USP27 full inspection passed.

Embodiment 3

[0016] In a 250ml four-necked reaction flask with stirring, add 20g of crude theobromine, 120ml of water, and 12ml of 30% liquid caustic soda, heat up to 70-80°C while stirring, and add 1g of activated carbon. Decolorize at this temperature for half an hour. Filter, add 0.4 g of sodium thiosulfate to the filtrate, stir and cool down to 70°C, keep at 65-70°C, acidify with concentrated hydrochloric acid to pH: 5-6, cool down to 25°C, filter, wash with deionized water until chloride ions Qualified, and dried to obtain 18.2 grams of theobromine finished product. According to cp2005, EP4, USP27 full inspection passed.

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PUM

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Abstract

The invention relates to a refining method of santheose, which is characterized in that dissolves liquid alkali into crude santheose solution, decolourizes, fitlers, and adds reduction agent into filter liquor, acidifies at 60-80DEG C until pH=1-5, filters and dries to obtain santheose final product. The inventive method has refining yield of 90%, standard product color, high product quality, low cost and industrialization suitability.

Description

technical field [0001] The invention belongs to a method for refining chemical products, in particular to a method for refining theobromine. Background technique [0002] Theobromine (English name: Theobromine, 3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione) is a central nervous system stimulant of xanthines. The crude product must first be refined by alkali (30% sodium hydroxide), and then the color of the solution after acid refining can meet the finished product standard. Refined twice, the refining rate is low. In addition, because sulfuric acid is destructive to a certain extent, a part of theobromine is lost, and the cost is high, which has an adverse effect on production. Contents of the invention [0003] The purpose of the present invention is to provide a simple method for refining theobromine with more industrial production value, the color of the finished product meets the standard, and the refining yield is high. [0004] A new method for refining theobromine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D473/10
Inventor 李兴泰舒瑞友丰宇胜杨爱荣赵丽
Owner PERRIGO TRADING (SHANGHAI) CO LTD
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