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Citicoline sodium dispersible tablets and preparation method thereof

A technology of citicoline sodium and dispersible tablets, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of inconvenient portability and use of injections, and limited use range, etc. Achieve the effect of being convenient for clinical application, simple in preparation method and good in stability

Inactive Publication Date: 2008-06-25
上海太平洋药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for patients with long-term use, injections are not easy to carry and use in daily life, which limits its scope of use

Method used

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  • Citicoline sodium dispersible tablets and preparation method thereof
  • Citicoline sodium dispersible tablets and preparation method thereof
  • Citicoline sodium dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Embodiment: the preparation and detection of CDP-C' dispersible tablet

[0011] 1. Preparation of dispersible tablets

[0012] Weigh CDP-C' and various auxiliary materials, mix them evenly and pass through an 80-mesh sieve, add binder, pass through a 20-mesh sieve to granulate, dry at 70°C, and test the content and moisture content. After drying, sieve and granulate, compress into tablets, and conduct full inspection after packaging.

[0013] 2. Uniformity of dispersible tablets

[0014] Take 2 CDP-C' dispersible tablets, put them in 100ml of water at 20°C±1°C, shake for 3 minutes, all of them disintegrate and pass through the No. 2 sieve.

[0015] 3. Stability of dispersible tablets

[0016] For showing the progress of the present invention, we have carried out stability test to CDP-C ' dispersible tablet, the results are shown in Table 1, Table 2 and Table 3.

[0017] Table 1 Test results of influencing factors of CDP-C' dispersible tablets

[0018]

[0019] ...

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PUM

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Abstract

The invention relates to a new oral preparation of a citicoline sodium. The preparation gives full play to the characteristic of a dispersible tablet which can quickly scatter. The preparation has the advantages of good stability, dissolubility and convenient clinical application.The preparation, mainly used as an activating agent for brain metabolism, is used for curing acute brain trauma, conscious disturbance after brain surgery, cerebrovascular subacute disorder, cerebrovascular sequela and parkinsonism, also the preparation can gradually restore the function of four limbs which are paralyzed caused by cerebral apoplexy; besides, the preparation can also be used for improving the disturbance of consciousness and function caused by other acute damages of central nervous system.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing citicoline sodium, and relates to an improved technology for oral solid preparation of citicoline sodium. It belongs to the technical field of western medicine preparations. Background technique [0002] Citicoline sodium (Citicoline Sodium, CDP-C') is a derivative of a single nucleotide and is an essential coenzyme for lecithin synthesis. It improves brain function by promoting the synthesis of lecithin, manifested as an improvement in consciousness, Cerebral blood flow increases and the uptake of oxygen is significantly improved. Improve brain metabolism and wakefulness by improving cerebral blood flow. Clinically, it is mainly used as an activator of brain metabolism, used for disturbance of consciousness accompanied by brain trauma and brain surgery, and has a significant effect on Parkinson's disease, depression and other mental diseases. [0003] At present, citicoline sodium inj...

Claims

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Application Information

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IPC IPC(8): A61K31/7068A61K9/20A61K47/38A61P25/00A61P25/16
Inventor 张云燕丁莉
Owner 上海太平洋药业有限公司
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