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Sheep oil nano emulsions and preparation and application thereof

A technology of nano-emulsion and lanolin, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of cosmetic inconvenience, stickiness, stickiness, etc., and achieve stable product quality, good water solubility, Easy to prepare effect

Inactive Publication Date: 2008-07-09
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The melting point of lanolin is about 35-45°C. It is almost insoluble in water and has good compatibility with other base materials of cosmetics. The preparation of its cosmetics brings great inconvenience, which limits its wide application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The preparation method of lanolin nanoemulsion provided by the invention is carried out as follows:

[0034] 1) 1-20% lanolin, 1-10% caprylic / capric glyceride and 1-10% phospholipids are prepared into a homogeneous mixture at a temperature of 40°C-60°C and stirring conditions;

[0035] 2) Add 50-94% glycerin and 1-20% underwater to the above mixed solution and stir evenly, and finally process it through a high-pressure homogenizer. A transparent or translucent lanolin nanoemulsion with a particle size less than 100nm.

[0036] In the above-mentioned method, carry out as follows for the preparation method of the lanolin nanoemulsion containing polyethylene glycol caprylic acid / capric glyceride:

[0037] 1) Mix 1-20% lanolin, 1-10% caprylic / capric glyceride, 0.1-2.5% polyethylene glycol caprylic / capric glyceride and 1-10% phospholipid at 40°C-60°C and stir Make a homogeneous mixture under the conditions;

[0038] 2) Add 50-94% glycerin and 1-20% underwater to the above...

Embodiment 1

[0041] Example 1 Weigh 1% soybean lecithin, 1% lanolin and 1% caprylic / capric glyceride and stir at 40°C to form a homogeneous mixture, then add 94% glycerin and 3% deionized water to the mixture and stir A uniform emulsion was formed, and finally the emulsion was processed through a high-pressure homogenizer for 8 cycles under a pressure of 500 bar to obtain a transparent lanolin nanoemulsion. The size of the lanolin nanoemulsion was measured by a laser particle size analyzer to be about 49nm.

Embodiment 2

[0042] Example 2 Weigh 5% egg yolk lecithin, 10% lanolin and 5% caprylic / capric glyceride and stir at 55°C to form a homogeneous mixture, then add 70% glycerin and 10% deionized water to the mixture and stir A uniform emulsion was formed, and finally the emulsion was processed through a high-pressure homogenizer cycle for 4 times under a pressure of 1000 bar to obtain a translucent lanolin nanoemulsion. The size of the lanolin nanoemulsion was measured by a laser particle size analyzer to be about 58nm.

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PUM

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Abstract

The present invention provides sheep oil nanometer latex, a preparation method and an application thereof and concretely relates to the sheep oil nanometer latex and the preparation method and the application thereof, which is characterized by mixing and emulsifying the following materials according to the weight percentage: 1 percent to 20 percent of the sheep oil, 1 percent to 10 percent of tricaprylin or tricaprin, 1 percent to 10 percent of phospholipid, 50 percent to 94 percent of glycerin, 2 percent to 20 percent of water, etc., orderly and uniformly under the temperature condition of 40 DEG C to 60 DEG C. Finally, a high pressure viscolizer is used for processing the materials to obtain the transparent or semitransparent sheep oil nanometer latex with average grain size less than 100nm. The sheep oil nanometer latex has the characteristics of high stability, water dispersibility, biological compatibility, etc., and being widely applied to the cosmetic field.

Description

technical field [0001] The invention relates to a lanolin nanoemulsion, which belongs to the technical field of cosmetics. Background technique [0002] Lanolin is a grease secretion deposited on wool. Its main components are sterols, fatty alcohols, triterpene alcohols and their fatty acid esters. In addition, it also contains free alcohols and a small amount of free fatty acids. The melting point of lanolin is about 35-45°C. It is almost insoluble in water and has good compatibility with other base materials of cosmetics. The preparation of its cosmetics brings great inconvenience, which limits its wide application. Contents of the invention [0003] The purpose of the invention is to provide a lanolin nanoemulsion with high stability, good compatibility and water solubility. [0004] The technical scheme adopted in the present invention is: [0005] A lanolin nanoemulsion is characterized in that: this lanolin nanoemulsion contains following component by weight perce...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/06A61Q19/00
Inventor 周华锋段明星郑昌学严泽民陈斌
Owner TSINGHUA UNIV