Pennogenin compounds solid state molecule dispersion preparation

Abstract

The invention relates to a special preparation form with pennogenyl saponin compounds as active components. The solid molecule pharmaceutical dispersion of the pennogenyl saponin compounds of the invention comprises 0.5 to 60 percent of pennogenyl saponin compounds and 40 to 99.5 percent of polyvinylpyrrolidone according to weight percentage. The invention has the advantages that the pennogenyl saponin compounds exist in a water-soluble solid phase carrier in the molecular disperse state with a dispersion degree up to 10 times less than nanosizing particles, and the invention can disintegrateand disperse quickly after entering the gastrointestinal tract and be absorbed by human body, thereby improving more than 2 times of biological availability. PVP series materials have very strong moisture absorption and disintegration property, and Polyxamer 188 and Myrij can further improve the quick-release property and enhance absorption. The preparation of the invention is mainly applied to gynaecological blood symptom comprising hemostasis, hematopoiesis and gynecological inflammation.

Description

[0001] This application is a divisional application of 200510010874.6, the filing date of the original application is June 24, 2005, the application number is 200510010874.6, and the name of the invention is: pinanoside compound solid molecular dispersion preparation. technical field [0002] The invention relates to a special preparation form with pinanoside compounds as active ingredients. Background technique [0003] Pinanoside is not very widely distributed in the plant kingdom, and its content is low. Chinese Patent Application No. 02150907.7 discloses a "17-hydroxy C#-[27] steroid compound, its synthesis method and its use", which can be used for the synthesis of pinatogenin or dihydro pinanogenin. [0004] At present, there have been literatures publicly reporting the application of pinanosides in pharmaceuticals. However, pharmacokinetic studies have shown that the bioavailability of pinanoside compounds is extremely low, and more than 90% of them are excreted from...

AI Technical Summary

Problems solved by technology

However, pharmacokinetic studies have shown that the bioavailability of pinanosides is extremely low, and more than 90% are excreted from the feces in the original form. Only a small amount of the original drug was detected in the blood, bile and urine samples, and no metabolites were detected.

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