Quercetin crosslinking method for preparing artificial bioprosthesis heart valve materials

A heart valve, quercetin technology, applied in the field of biomedical engineering, can solve problems such as fragility, affecting the working period of biological valves, and becoming brittle
CN101224313AInactive Publication Date: 2008-07-23SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Publication Date
2008-07-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a cross-linking preparing method for heart valve prosthesis material, comprising a cross-linker, cross-linking steps and preserving treatment after cross-linking. The method is characterized in that the collected cardiac valve of a pig is timely and appropriately treated and cleaned, and then the cells are completely removed and cleaned, then the obtained cells are cross-linked by quercetin, thus improving the mechanical strength, further eliminating the antigenicity and enhancing the stability. The acellular bioprothesis cardiac valve of the pig adopts heart valve prosthesis prepared by the method has the advantages of non-toxic valve, high tensile strength, resistance to enzymic degradation and minimum release of the cross-linker and self-protein of valves. The cross-linking properties of the acellular bioprothesis cardiac valve made of cardiac valve material of the pig are beneficial to transplanting, proliferation, covering and long-term anti-calcification of interstitial cells of valves of the body of man and vascular endothelial cells after being transplanted into the human body.
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Description

technical field

[0001] The invention relates to a crosslinking preparation method of an artificial biological heart valve material, which belongs to the field of biomedical engineering. Background technique

[0002] Worldwide, heart valve disease is associated with high morbidity and mortality. In the United States, 60,000 artificial heart valve replacement operations are performed every year, and about 20,000 people die directly from the disease [Julie R, BorisAN, Vacanti JP. Tissue engineering: a 21st century solution to surgical reconstruction. Ann thorac surg, 2001, 72 : 577-591.]. Clinically, artificial heart valves are mainly treated with mechanical valves and heterogeneous biological valves. Human allograft biological valves stored at low temperature are also used clinically, but they are rarely used due to insufficient sources. The coagulation effect of heterogeneous biological valves is weak, and patients do not need to take anticoagulant drugs after surgery. Co...

Claims

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