Medicine compounds containing levamlodipine and pitavastatin
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of levamlodipine and pitavastatin, applied in the field of medicine, can solve the problems of different affinities, different effect strengths and the like
Inactive Publication Date: 2008-07-30
BEIJING RUNDEKANG MEDICAL TECH CO LTD
View PDF0 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Statins have different affinities to HMG-CoA reductase, so the strength of action is different
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0011] Embodiment 1 levamlodipine and pitavastatin tablet
[0012] prescription:
[0013] components
Dosage
Levoamlodipine
Pitavastatin
microcrystalline cellulose
pregelatinized starch
lactose
Magnesium stearate
2.5g
1g
60g
15g
30g
2.5g
[0014] 95% ethanol
Co-made
Appropriate amount
1000 pieces
[0015] Preparation:
[0016] Pass levamlodipine, pitavastatin, microcrystalline cellulose, pregelatinized starch and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, 18-mesh Sieve for granulation, add magnesium stearate, mix evenly, and press a suitable die to form a tablet.
Embodiment 2
[0017] Embodiment 2: levamlodipine and pitavastatin capsules
[0018] prescription:
[0019] components
Dosage
Levoamlodipine
Pitavastatin
microcrystalline cellulose
0.5% PVP-k 30 ethanol solution
Talc powder
Co-made
5g
1g
85g
Appropriate amount
3.5g
1000 capsules
[0020] Preparation:
[0021] Pass levamlodipine, pitavastatin, and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 0.5% PVP-k30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, and granulate with 24-mesh sieve , add the prescribed amount of talcum powder, mix evenly and put it into a suitable capsule shell.
Embodiment 3
[0022] Embodiment 3: levamlodipine and pitavastatin soft capsules
[0023] prescription:
[0024] components
Dosage
Levoamlodipine
Pitavastatin
PEG400
Propylene Glycol
Tween 80
Co-made
2.5g
1g
170g
10g
7.5g
1000 capsules
[0025] Preparation:
[0026] First heat about 80% PEG400 to 40-60°C, add levamlodipine and pitavastatin, stir to dissolve, then add the prescribed amount of propylene glycol and Tween-80, stir evenly, then add the remaining amount of PEG400 to obtain Clarity solution; adjust the weight of the content, press, that is.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a medical composition containing L-amlodipine and Pitavastatin and a preparation method thereof. The L-amlodipine and the Pitavastatin or the pharmaceutically acceptable salt of the two medicines are taken as medical active components and mixed with the pharmaceutically acceptable supplements to form a medical combination. The L-amlodipine and Pitavastatin or the pharmaceutically acceptable salt of the two medicines are taken as raw materials, a plurality of supplements with special type and proportion are added, and the oral preparations such as tablet, capsule, soft capsule, chewable tablet, orally disintegrating tablet, buccal tablet and dropping pill can be prepared and developed according to the technical method described by the invention. The medical composition of the invention can be applied to treat all kind of hypertensions.
Description
technical field [0001] The invention relates to a pharmaceutical composition containing levamlodipine and pitavastatin and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Levoamlodipine is a dihydropyridine calcium antagonist (calcium antagonist or slow channel blocker). The contraction of cardiac and smooth muscles depends on the entry of extracellular calcium ions into the cells through specific ion channels. This product selectively inhibits the transmembrane entry of calcium ions into smooth muscle cells and cardiomyocytes, and its effect on smooth muscle is greater than that on cardiac muscle. Its interaction with the calcium channel is determined by the progressive rate of its binding and dissociation to the receptor site, so the pharmacological effect occurs gradually. The activity of levamlodipine is 1000 times that of the dextro-form and twice that of the racemate. This product is a peripheral artery dil...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more