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Medicine compounds containing levamlodipine and pitavastatin

A technology of levamlodipine and pitavastatin, applied in the field of medicine, can solve the problems of different affinities, different effect strengths and the like

Inactive Publication Date: 2008-07-30
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Statins have different affinities to HMG-CoA reductase, so the strength of action is different

Method used

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  • Medicine compounds containing levamlodipine and pitavastatin
  • Medicine compounds containing levamlodipine and pitavastatin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 levamlodipine and pitavastatin tablet

[0012] prescription:

[0013] components

Dosage

Levoamlodipine

Pitavastatin

microcrystalline cellulose

pregelatinized starch

lactose

Magnesium stearate

2.5g

1g

60g

15g

30g

2.5g

[0014] 95% ethanol

Co-made

Appropriate amount

1000 pieces

[0015] Preparation:

[0016] Pass levamlodipine, pitavastatin, microcrystalline cellulose, pregelatinized starch and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, 18-mesh Sieve for granulation, add magnesium stearate, mix evenly, and press a suitable die to form a tablet.

Embodiment 2

[0017] Embodiment 2: levamlodipine and pitavastatin capsules

[0018] prescription:

[0019] components

Dosage

Levoamlodipine

Pitavastatin

microcrystalline cellulose

0.5% PVP-k 30 ethanol solution

Talc powder

Co-made

5g

1g

85g

Appropriate amount

3.5g

1000 capsules

[0020] Preparation:

[0021] Pass levamlodipine, pitavastatin, and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 0.5% PVP-k30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, and granulate with 24-mesh sieve , add the prescribed amount of talcum powder, mix evenly and put it into a suitable capsule shell.

Embodiment 3

[0022] Embodiment 3: levamlodipine and pitavastatin soft capsules

[0023] prescription:

[0024] components

Dosage

Levoamlodipine

Pitavastatin

PEG400

Propylene Glycol

Tween 80

Co-made

2.5g

1g

170g

10g

7.5g

1000 capsules

[0025] Preparation:

[0026] First heat about 80% PEG400 to 40-60°C, add levamlodipine and pitavastatin, stir to dissolve, then add the prescribed amount of propylene glycol and Tween-80, stir evenly, then add the remaining amount of PEG400 to obtain Clarity solution; adjust the weight of the content, press, that is.

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PUM

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Abstract

The invention relates to a medical composition containing L-amlodipine and Pitavastatin and a preparation method thereof. The L-amlodipine and the Pitavastatin or the pharmaceutically acceptable salt of the two medicines are taken as medical active components and mixed with the pharmaceutically acceptable supplements to form a medical combination. The L-amlodipine and Pitavastatin or the pharmaceutically acceptable salt of the two medicines are taken as raw materials, a plurality of supplements with special type and proportion are added, and the oral preparations such as tablet, capsule, soft capsule, chewable tablet, orally disintegrating tablet, buccal tablet and dropping pill can be prepared and developed according to the technical method described by the invention. The medical composition of the invention can be applied to treat all kind of hypertensions.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing levamlodipine and pitavastatin and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Levoamlodipine is a dihydropyridine calcium antagonist (calcium antagonist or slow channel blocker). The contraction of cardiac and smooth muscles depends on the entry of extracellular calcium ions into the cells through specific ion channels. This product selectively inhibits the transmembrane entry of calcium ions into smooth muscle cells and cardiomyocytes, and its effect on smooth muscle is greater than that on cardiac muscle. Its interaction with the calcium channel is determined by the progressive rate of its binding and dissociation to the receptor site, so the pharmacological effect occurs gradually. The activity of levamlodipine is 1000 times that of the dextro-form and twice that of the racemate. This product is a peripheral artery dil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K9/20A61K9/48A61P9/12A61K31/4422
Inventor 严轶东
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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