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Depression treating medicine composition and preparation method thereof

A composition and technology for depression, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of decreased cognitive function and emotional self-regulation ability, inability to adapt, decreased neuronal plasticity, etc.

Active Publication Date: 2008-08-20
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is, on the basis of genetic factors, under the stress of environmental factors, specific parts of the brain of genetically vulnerable individuals, mainly the limbic system, especially the neuronal apoptosis and regeneration conjugate balance in the hippocampus and frontal cortex Disorder, the continuation of the disorder state will lead to the loss of nerve cells, even localized brain atrophy, the disorder of the negative feedback mechanism of the HPA axis of the body and the decline of monoamine, especially 5-HT nerve function, which will lead to the decrease of the plasticity of the body's neurons and the inability to adapt to the environment The role of stress factors, the decline of cognitive function and emotional self-regulation ability, presents an overreaction, causing depression with mainly emotional changes, accompanied by changes in immune endocrine function and other neurological dysfunction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 capsule of the present invention

[0017] Bupleurum 660g, white peony 660g, turmeric 660g, calamus 660g

[0018] The above four flavors are decocted twice, adding 10 times of water for the first time, and 8 times of water for the second time, each time for 1.5 hours, filtering, combining the filtrate and the above aqueous solution, and concentrating to a thick liquid with a relative density of 1.25 (70°C). The paste is dried, pulverized, passed through a 60-mesh sieve, added 5% talcum powder and 0.5% magnesium stearate (based on the weight of the extract powder), mixed evenly, packed into capsules, and made into 1000 capsules to obtain final product.

Embodiment 2

[0019] The preparation of embodiment 2 granules of the present invention

[0020] Take 200g of Radix Bupleuri, 200g of Radix Paeoniae Alba, 200g of Radix Curcuma, and 200g of Acorus albus, add excipients to the thick paste prepared by the method in Example 1, granulate and granulate to obtain granules.

Embodiment 3

[0021] The preparation of embodiment 3 oral liquid of the present invention

[0022] Take 400g of Radix Bupleuri, 400g of Radix Paeoniae Alba, 400g of Radix Curcuma, and 100g of Acorus albus, and prepare the thick ointment according to the method in Example 1, and add auxiliary materials for oral liquid to prepare oral liquid.

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PUM

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Abstract

The invention provides a medicine composition used to cure melancholia, which is a preparation with the following raw materials in weight proportions: 2 - 4 portions of radix bupleuri, 2 - 4 portion of radix curcumae, 2 - 4 portions of acorus gramineus, and 1- 2 portions of Paeonia lactiflora pallas. The invention also provides the preparation method and purposes of the medicine composition. The medicine composition in the invention has the advantages of apparent therapeutic effects, safety, and controllability.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating depression, in particular, the pharmaceutical composition is prepared from Bupleurum radix, Radix Paeoniae Alba, Curcuma curcuma and Calamus calamus as raw materials. It belongs to the field of traditional Chinese medicine. Background technique [0002] Depression is an affective or mood disorder. The basic clinical manifestation is a significant and persistent low mood, showing a state of no desire, boredom, helplessness, hopelessness, and no pleasure. In severe cases, suicidal ideation appears. Its etiology and pathogenesis are unknown, and there are many hypotheses: such as monoamine hypothesis, hypothalamus-pituitary-adrenal (HPA) axis negative feedback disorder hypothesis, cell molecular mechanism hypothesis, brain cell regeneration-apoptosis hypothesis, etc. It is generally believed that depression is a mental-emotional disorder related to genetic factors and caused by environmen...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/24A61P25/20
Inventor 赵军宁易进海王晓东
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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