Bilobalide A, B compound injection and preparation method and application thereof

A technology of ginkgolide and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of poor stability, easy crystallization, and many ingredients. Achieve the effects of simple and controllable preparation process, improved low temperature stability, and improved validity period
CN101249085AInactive Publication Date: 2008-08-27广州艾格生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
广州艾格生物科技有限公司
Publication Date
2008-08-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a ginkgolide injection and a preparation method thereof. The ginkgolide injection contains an active component and adjuvant for injection, wherein the active component is composed of ginkgolide A and ginkgolide B. Experimental studies shows that the preparation containing the combination of ginkgolide A and ginkgolide B has synergic effect and excellent mutual solubility thereof, increases the solubility of ginkgolide B and improves stability at a low temperature. Tests prove that the inventive ginkgolide injection has improved stability at a low temperature, so that the shelf life, safety and effectiveness of the injection in cold areas are improved.
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Description

technical field

[0001] The invention relates to a ginkgolide injection and a preparation method thereof. The ginkgolide injection uses ginkgolide A and ginkgolide B as main ingredients. It belongs to the field of pharmaceutical preparations. Background technique

[0002] Ginkgo biloba and Ginkgo biloba are commonly used traditional Chinese medicines for the treatment of cardiovascular and cerebrovascular diseases, and their main active ingredients are ginkgolides, which have been proved to be strong platelet activating factor (plateletacllvatfactor, PAF) receptor antagonists. In recent years, its single active ingredient new drug has become the target of competing development. For example, CN1513449 discloses a ginkgolide B injection and a preparation method thereof, the method is to dissolve ginkgolide B in a non-aqueous solvent for injection, such as polyethylene glycol, add or not add absolute ethanol to form a mixed solvent, add Or without adding surfactant, the produc...

Claims

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