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Bilobalide A, B compound injection and preparation method and application thereof

A technology of ginkgolide and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of poor stability, easy crystallization, and many ingredients. Achieve the effects of simple and controllable preparation process, improved low temperature stability, and improved validity period

Inactive Publication Date: 2008-08-27
广州艾格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of total ginkgolides and the mixture of ginkgolides A, B and C has many components and the content of each component is not easy to control.
Ginkgolide B injection has poor stability in low temperature environment and is prone to crystallization, which affects the safety and efficacy of the preparation

Method used

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  • Bilobalide A, B compound injection and preparation method and application thereof
  • Bilobalide A, B compound injection and preparation method and application thereof
  • Bilobalide A, B compound injection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Ginkgolide A 3000mg

[0125] Ginkgolide B 3000mg

[0126] Polyethylene glycol 200 1000ml

[0127]

[0128] Preparation: take the test amount of ginkgolide A and ginkgolide B, add 1000ml polyethylene glycol 200, dissolve, add 500mg of activated carbon, keep warm at 80°C for 15min, after intermediate detection, filtration, potting, sterilization, light inspection, packaging , that is.

Embodiment 2

[0130] Ginkgolide A 2000mg

[0131] Ginkgolide B 1000mg

[0132] Polyethylene glycol 600 800ml

[0133] Ethanol 80ml

[0134]

[0135] Add water for injection to 1000ml

[0136] Preparation: take test amount of ginkgolide A and ginkgolide B, add 800ml of polyethylene glycol 600 to dissolve at 40°C, add 500mg of activated carbon, keep warm at 80°C for 15min, add 80ml of ethanol, add water for injection to 1000ml, pass through the intermediate Detection, filtration, potting, sterilization, light inspection, packaging, and you get it.

Embodiment 3

[0138] Ginkgolide A 1000mg

[0139] Ginkgolide B 2000mg

[0140] Polyethylene glycol 400 800ml

[0141] Proxamer 50mg

[0142] Propylene glycol 80ml

[0143]

[0144] Add water for injection to 1000ml

[0145] Preparation: take the test amount of ginkgolide A and ginkgolide B, add 800ml polyethylene glycol 400 at 40°C, add 50mg of proxamer to dissolve, add 500mg of activated carbon, keep warm at 80°C for 15min, add 80ml of propylene glycol, and inject Water to 1000ml, after intermediate detection, filtration, potting, sterilization, lamp inspection, packaging, to obtain.

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PUM

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Abstract

The invention relates to a ginkgolide injection and a preparation method thereof. The ginkgolide injection contains an active component and adjuvant for injection, wherein the active component is composed of ginkgolide A and ginkgolide B. Experimental studies shows that the preparation containing the combination of ginkgolide A and ginkgolide B has synergic effect and excellent mutual solubility thereof, increases the solubility of ginkgolide B and improves stability at a low temperature. Tests prove that the inventive ginkgolide injection has improved stability at a low temperature, so that the shelf life, safety and effectiveness of the injection in cold areas are improved.

Description

technical field [0001] The invention relates to a ginkgolide injection and a preparation method thereof. The ginkgolide injection uses ginkgolide A and ginkgolide B as main ingredients. It belongs to the field of pharmaceutical preparations. Background technique [0002] Ginkgo biloba and Ginkgo biloba are commonly used traditional Chinese medicines for the treatment of cardiovascular and cerebrovascular diseases, and their main active ingredients are ginkgolides, which have been proved to be strong platelet activating factor (plateletacllvatfactor, PAF) receptor antagonists. In recent years, its single active ingredient new drug has become the target of competing development. For example, CN1513449 discloses a ginkgolide B injection and a preparation method thereof, the method is to dissolve ginkgolide B in a non-aqueous solvent for injection, such as polyethylene glycol, add or not add absolute ethanol to form a mixed solvent, add Or without adding surfactant, the produc...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/343A61K9/08A61K47/34A61P9/00A61K47/10A61K47/26
Inventor 张雷红
Owner 广州艾格生物科技有限公司
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