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Chinese medicine injection and method of preparing the same and medicament use

A technology of injection and water for injection, applied in the direction of medical formula, drug combination, medical preparations containing active ingredients, etc., to achieve the effect of improving prognosis, obvious neuroprotective effect, and promoting neurological recovery

Inactive Publication Date: 2008-08-27
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy and safety of the drug still need greater breakthroughs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] This embodiment is a traditional Chinese medicine injection (water injection) made from the following parts by weight of traditional Chinese medicine extracts:

[0056] 10 parts of total saponins extract of ginseng stems and leaves, 10 parts of total flavonoids extract of breviscapine, 5 parts of total caffeate extract of breviscapine.

[0057] among them:

[0058] The total saponins extract of ginseng stems and leaves is extracted from ginseng stems and leaves by the following method:

[0059] ①Water extraction: take ginseng stems and leaves, crush them, add 8 times the amount of water to extract 3 times, 1 hour each time, combine the water extracts and concentrate to 1 / 2 of the weight of the medicinal materials;

[0060] ②Alcohol precipitation: Add ethanol to the concentrated water extract of the above ① to make the ethanol concentration reach 70%, refrigerate below 4℃, stand for more than 24 hours, filter, and recover the ethanol from the filtrate, and then filter;

[00...

Embodiment 2

[0075] This embodiment is a traditional Chinese medicine injection (water injection) made from the following parts by weight of traditional Chinese medicine extracts:

[0076] 20 parts of total saponins extract of ginseng stems and leaves, 15 parts of total flavonoids extract of breviscapine, and 2 parts of total caffeate extract of breviscapine.

[0077] among them:

[0078] The total saponins extract of ginseng stems and leaves is extracted from the traditional Chinese medicine ginseng stems and leaves by the following method:

[0079] ①Water extraction: take the ginseng stem and leaf medicinal material, crush it, add 10 times the amount of water to extract twice, the first time is 2 hours, the second time is 1 hour, and the water extracts are combined and concentrated to 1 / 3 of the weight of the medicinal material;

[0080] ②Alcohol precipitation: add ethanol to the concentrated water extract mentioned above to make the ethanol concentration reach 85%, refrigerate at 4°C, stand...

Embodiment 3

[0095] This embodiment is a traditional Chinese medicine injection (water injection) made from the following parts by weight of traditional Chinese medicine extract:

[0096] 15 parts of ginseng stem and leaf total saponins extract, 1 part of breviscapine total flavonoids extract, 15 parts of breviscapine total caffeate extract.

[0097] among them:

[0098] The total saponins extract of ginseng stems and leaves is extracted from the traditional Chinese medicine ginseng stems and leaves by the following method:

[0099] ①Water extraction: take ginseng stems and leaves, crush them, add 12 times the amount of water for 3 hours, and concentrate the water extract to 1 / 4 of the weight of the medicinal materials;

[0100] ②Alcohol precipitation: add ethanol to the concentrated aqueous extract of the above ① to make the ethanol concentration reach 60%, refrigerate at 4°C, stand for 36 hours, filter, recover the ethanol from the filtrate, and then filter;

[0101] ③Over-macroporous resin ...

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Abstract

The invention discloses a traditional Chinese medicine injection, which mainly makes a squirt cut by a traditional Chinese medicine extract according to the proportion by weight as follows: the total saponin extract of ginseng or ginseng cauline leaf is 1 to 20 parts, the total flavone extract of erigeron is 1 to 20 parts, and the total caffeic acid ester of the erigeron is 1 to 20 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc. More particularly, for the improved aspect to the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance. The invention further discloses a preparation method of the traditional Chinese medicine injection and the pharmaceutical application.

Description

Technical field [0001] The invention belongs to the technical field of medical preparations, and particularly relates to a traditional Chinese medicine injection containing a traditional Chinese medicine extract, and a preparation method and medical use thereof. Background technique [0002] Nerve injury mainly includes brain nerve injury, spinal cord nerve injury and peripheral nerve injury. [0003] Cranial nerve damage includes brain trauma, sequelae of cerebrovascular sclerosis (cerebral hemorrhage, cerebral thrombosis), sequelae of encephalitis and meningitis, demyelinating disease and other sequelae of cerebrovascular disease. If ischemic cerebrovascular disease is not treated in time, nerve damage will produce sequelae, which can be manifested as mental retardation, memory decline, attention deficit disorder, mood changes and other obstacles. [0004] Direct or indirect violence on the spine and spinal cord can cause spinal cord injury. Immediately after spinal cord injury...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P25/00A61P9/10
Inventor 唐德江陈犁李文军
Owner 重庆希尔安药业有限公司
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